MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

Abstract

The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08–7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61–8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92–22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10–10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22–0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.

Expression of miR‐100 and miR‐138 as prognostic biomarkers in non‐muscle‐invasive bladder cancer

“…Concerning clinical significance, there are controversial results with some studies showing that miR‐100 downregulation is associated with unfavorable prognosis . Nevertheless, other studies, which are in line with our result, indicate that miR‐100 downregulation is associated with a better outcome .…”

“…Recent data suggest that microRNA profiles can distinguish between different histological types, and separate them in different grade and stage categories . Thus, there is strong interest in finding microRNA activity‐based biomarkers since they might provide insights regarding which patient may have a better prognosis.…”

“…Recent studies have reported a number of microRNAs, including miR‐21, miR‐143, miR‐155, miR‐214, and miR‐222, that could potentially serve as risk stratified. However, studies with long‐term follow‐up are needed to verify the potential prognostic significance of these microRNAs .…”

MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients

“…Serum levels of miRNA-143 in bladder cancer correlate with clinical stage, lymph node metastasis, distant metastasis, and prognosis Despite high levels of miRNA-143 correlating with poor progression-free survival in aggressive bladder cancer [174] this miRNA has been shown to enhance sensitivity to gemcitabine in 5637 cells; this was proposed to be via repression of IGF-1R signaling Further to this, in vitro experiments which induced FOXD2-AS1 knockdown, a long non-coding RNA which can inhibit miRNA-143, enhanced sensitivity to gemcitabine [175].…”

MKAD-21 Suppresses the Oncogenic Activity of the miR-21/PPP2R2A/ERK Molecular Network in Bladder Cancer

“…It has been reported that miR-21 is overexpressed in multiple human solid tumors, including bladder cancer (5,6). A systematic review and meta-analysis showed that elevated miR-21 expression is associated with poor overall survival and proposed that miR-21 may serve as follow-up marker for early detection of bladder cancer progression or recurrence (7). Furthermore, miR-21:miR-205 ratio has been described as a tool for identifying the invasive capacity of bladder tumors with high sensitivity and specificity (6).…”