microRNAs: Small molecules with a large impact on colorectal cancer

Moazzendizaji, Sahand; Севбитов, А.В.; Ezzatifar, Fatemeh; Jalili, Hamid Reza; Aalii, Morteza; Hemmatzadeh, Maryam; Aslani, Saeed; Navashenaq, Jamshid Gholizadeh; Safari, Roghaiyeh; Hosseinzadeh, Reza; Rahmany, Mohammad Reza; Mohammadi, Hamed

doi:10.1002/bab.2255

Cited by 13 publications

(7 citation statements)

References 156 publications

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“…However, there is currently not yet a clear recommendation about the clinical use of these tests. It may be possible, as we previously hypothesized [36], that thanks to the features of ease-of-collection and non-invasiveness, these novel screening techniques, by meeting patient preferences, will improve screening uptake [157,158]. Since none of the retrieved studies (up to July 2021) have investigated population preferences for biomarker-based screening tests, further research is needed to validate this hypothesis.…”

Section: Discussionmentioning

confidence: 95%

“…With regards to perceived invasiveness, it should be noted that a number of newer and promising screening technologies that employ biomarkers such as panels of methylated genes (e.g., SEPT9), microRNAs (miRNA) and protein panels, which can be performed on both blood, stool and, in some cases, urine samples, may become available on the market in the near future [36,157,158]. However, there is currently not yet a clear recommendation about the clinical use of these tests.…”

Section: Discussionmentioning

confidence: 99%

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Colorectal Cancer Screening: Have We Addressed Concerns and Needs of the Target Population?

Tran

Ferrari

Hoeck

et al. 2021

Gastrointestinal Disorders

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Despite the recognized benefits of colorectal cancer (CRC) screening, uptake is still suboptimal in many countries. In addressing this issue, one important element that has not received sufficient attention is population preference. Our review provides a comprehensive summary of the up-to-date evidence relative to this topic. Four OVID databases were searched: Ovid MEDLINE® ALL, Biological Abstracts, CAB Abstracts, and Global Health. Among the 742 articles generated, 154 full texts were selected for a more thorough evaluation based on predefined inclusion criteria. Finally, 83 studies were included in our review. The general population preferred either colonoscopy as the most accurate test, or fecal occult blood test (FOBT) as the least invasive for CRC screening. The emerging blood test (SEPT9) and capsule colonoscopy (nanopill), with the potential to overcome the pitfalls of the available techniques, were also favored. Gender, age, race, screening experience, education and beliefs, the perceived risk of CRC, insurance, and health status influence one’s test preference. To improve uptake, CRC screening programs should consider offering test alternatives and tailoring the content and delivery of screening information to the public’s preferences. Other logistical measures in terms of the types of bowel preparation, gender of endoscopist, stool collection device, and reward for participants can also be useful.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Screening: Have We Addressed Concerns and Needs of the Target Population?

Tran

Ferrari

Hoeck

et al. 2021

Gastrointestinal Disorders

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“…In addition to protein-coding transcripts, the transcriptome also consists of many noncoding RNA species, including both small and long noncoding RNAs. The functions of these RNAs have been extensively examined and implicated in important biological pathways [25][26][27][28]. The small noncoding RNAs present a unique opportunity to new therapeutic approaches [29].…”

Section: Transcriptomementioning

confidence: 99%

Decoding the Equine Genome: Lessons from ENCODE

Peng

Petersen

Kalbfleisch

et al. 2021

Genes

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The horse reference genome assemblies, EquCab2.0 and EquCab3.0, have enabled great advancements in the equine genomics field, from tools to novel discoveries. However, significant gaps of knowledge regarding genome function remain, hindering the study of complex traits in horses. In an effort to address these gaps and with inspiration from the Encyclopedia of DNA Elements (ENCODE) project, the equine Functional Annotation of Animal Genome (FAANG) initiative was proposed to bridge the gap between genome and gene expression, providing further insights into functional regulation within the horse genome. Three years after launching the initiative, the equine FAANG group has generated data from more than 400 experiments using over 50 tissues, targeting a variety of regulatory features of the equine genome. In this review, we examine how valuable lessons learned from the ENCODE project informed our decisions in the equine FAANG project. We report the current state of the equine FAANG project and discuss how FAANG can serve as a template for future expansion of functional annotation in the equine genome and be used as a reference for studies of complex traits in horse. A well-annotated reference functional atlas will also help advance equine genetics in the pan-genome and precision medicine era.

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“…MiRNA was a kind of endogenous non-coding RNA, extensively participating in gene post-transcriptional regulation activities. [33] MiRNA could inhibit target gene expression at protein translation level and induce the degradation of target mRNA. [34] MiR-164a and miR-21 were found to be upregulated over 2-fold in the OLP samples.…”

Section: Degs Of Olpmentioning

confidence: 99%

Bioinformatics analysis of differentially expressed genes and their potentially interacting miRNAs in oral lichen planus

Zhang

Sun

2021

Preprint

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Background. Among the diseases of oral mucosa, oral lichen planus (OLP) is characterized by chronic autoimmune/autoinflammation. However, the etiology and pathogenesis of OLP were still limited. The aim of this research was to identify the differentially expressed genes and their potentially interacted miRNAs in OLP to provide a possible explanation of the pathogenesis of OLP and therapeutic biomarkers.Methods. The OLP microarray dataset (GSE52130) was download from the Gene Expression Omnibus (GEO) database. R software was used to identify differentially expressed genes between the OLP samples and normal oral mucosa. Functional enrichment analysis of DEGs, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, were conducted. Protein–protein interaction (PPI) network analysis was performed in the STRING database. CytoHubba in the Cytoscape software was applied to determining the top 10 hub genes, whose relative miRNA was identified through RNA Interactome Database.Results. Overall, 627 DEGs was identified in OLP samples, including 351 highly expressed genes and 276 lowly expressed genes. GO analysis indicated that the epidermal differentiation was mostly enriched. For the KEGG pathway, the DEGs in OLP samples were mostly involved in Staphylococcus aureus infection, Estrogen signaling pathway, Serotonergic synapse and Histidine metabolism. Top 10 hub genes including LOR, LCE3D, LCE3E, LCE1B, LCE2B, SPRR2E, SPRR2G, LCE2A, RPTN and CDSN were identified from the PPI network. The miRNA (hsa-miR-98-5p) was regarded as the mostly possible miRNA involved in OLP.

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microRNAs: Small molecules with a large impact on colorectal cancer

Cited by 13 publications

References 156 publications

Colorectal Cancer Screening: Have We Addressed Concerns and Needs of the Target Population?

Colorectal Cancer Screening: Have We Addressed Concerns and Needs of the Target Population?

Decoding the Equine Genome: Lessons from ENCODE

Bioinformatics analysis of differentially expressed genes and their potentially interacting miRNAs in oral lichen planus

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