MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus

Wang, Hsiuying

doi:10.3390/ijms22062953

Cited by 16 publications

(10 citation statements)

References 206 publications

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“…ese miRNAs mediate the insulin pathway, glucose absorption, and PD-related genes. erefore, studying the common miRNA biomarkers of both PD and DM can explain how these two diseases are correlated, and targeting miRNAs may have a therapeutic value [25].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Elgnainy

Hamed

Mohamed

et al. 2021

Neurology Research International

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Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls ( p < 0.001 ), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 ( p < 0.001 ) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p = 0.013 ). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS ( p < 0.001 ). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Elgnainy

Hamed

Mohamed

et al. 2021

Neurology Research International

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“…Another pathway relates to common changes in the microtubule-associated protein tau (MAPT) [ 44 ]. Additionally, patients with PD and patients with type 1 and 2 diabetes share abnormal concentrations of some microRNAs that are important for epigenetic modification (reviewed by [ 45 ]).…”

Section: Sugar Intake Dopamine and Insulin In Parkinson’s Diseasementioning

confidence: 99%

Parkinson’s Disease and Sugar Intake—Reasons for and Consequences of a Still Unclear Craving

et al. 2022

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Lately, studies have shown that patients with Parkinson’s disease (PD) report a strong craving for sweets and consume significantly more fast-acting carbohydrates than healthy controls. Consuming food with a high-sugar content is assumed to lead to an increase in insulin concentration, which could positively influence dopamine concentration in the brain and unconsciously be used by patients as kind of “self-medication” to compensate for a lack of dopamine in PD. On the other hand, high-sugar intake could also lead to insulin resistance and diabetes, which is discussed as a causative factor for progressive neurodegeneration in PD. In this critical appraisal, we discuss the role of sugar intake and insulin on dopamine metabolism in patients with PD and how this could influence the potential neurodegeneration mediated by insulin resistance.

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“…miRNAs can be used as genetic biomarkers for various diseases. miRNAs can regulate the protein-coding genes in the human genome ( 22 ), and they are well known to be involved in the initiation and progression of many diseases including cancers, neurological diseases, gastroesophageal reflux, and diabetes ( 23 – 30 ). In addition, miRNAs might be important modulators of viral infections and play a role in the treatment of viral infections ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA

Wang

2022

Front. Immunol.

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The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased. Many case reports have revealed that COVID-19 may induce other serious comorbidities such as anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis is an acute autoimmune disease that occurs more commonly in women than in men. To explore the association between COVID-19 and anti-NMDA receptor encephalitis, the microRNA (miRNA) biomarkers of COVID-19, anti-NMDA receptor encephalitis, and other related diseases from the literature are reviewed; then on the basis of these miRNA biomarkers, the relationship between COVID-19 and anti-NMDA receptor encephalitis is discussed. miRNAs are small non-coding RNAs that play important roles in cell differentiation, development, cell-cycle regulation, and apoptosis. miRNAs have been used as biological biomarkers for many diseases. The results in this study reveal that the relationship between anti-NMDA receptor encephalitis and COVID-19 infection or COVID-19 vaccination cannot be excluded; however, the risk that COVID-19 triggers the anti-NMDA receptor encephalitis is not high.

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MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus

Cited by 16 publications

References 206 publications

Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Parkinson’s Disease and Sugar Intake—Reasons for and Consequences of a Still Unclear Craving

COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA

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