MicroRNAs: Novel regulators in the hallmarks of human cancer

Ruan, Kai; Fang, Xiaoguang; Ouyang, Gaoliang

doi:10.1016/j.canlet.2009.04.031

Cited by 403 publications

(293 citation statements)

References 143 publications

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“…MiRNAs have been identified to participate in a variety of cell biological processes such as proliferation, apoptosis, migration and invasion 3, 4. During the development of cancer, miRNAs are dysregulated and play oncogenic or tumour suppressive role by enhancing or suppressing proliferation, invasion of tumour cells 5, 6. Thus, miRNA deregulation is one of the key mechanisms in glioma pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

The emerging role of miR‐19 in glioma

Wang

Zhang

Hao

et al. 2018

J Cellular Molecular Medi

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Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.

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Section: Introductionmentioning

confidence: 99%

The emerging role of miR‐19 in glioma

Wang

Zhang

Hao

et al. 2018

J Cellular Molecular Medi

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“…miRNAs play a critical role in a wide range of biological processes such as cellular proliferation, embryonic development, and tumorigenesis. 136 A direct link between miRNAs and cancer was first recognized when miR-15 and miR-16 were deleted or downregulated in B-cell chronic lympholytic leukemia (B-CLL). 136 Studies have revealed that miRNAs can function as tumor promoters or suppressors that modulate cancer-related genes involved in cell proliferation and apoptosis.…”

Section: Src Contact Normalization and Mirna Expressionmentioning

confidence: 99%

“…136 A direct link between miRNAs and cancer was first recognized when miR-15 and miR-16 were deleted or downregulated in B-cell chronic lympholytic leukemia (B-CLL). 136 Studies have revealed that miRNAs can function as tumor promoters or suppressors that modulate cancer-related genes involved in cell proliferation and apoptosis. 137 Also, there is growing evidence linking miRNAs to tumor cell migration and metastasis.…”

Section: Src Contact Normalization and Mirna Expressionmentioning

confidence: 99%

Src Points the Way to Biomarkers and Chemotherapeutic Targets

Krishnan¹,

Miller

Goldberg³

2012

Genes & Cancer

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The role of Src in tumorigenesis has been extensively studied since the work of Peyton Rous over a hundred years ago. Src is a non-receptor tyrosine kinase that plays key roles in signaling pathways controlling tumor cell growth and migration. Src regulates the activities of numerous molecules to induce cell transformation. However, transformed cells do not always migrate and realize their tumorigenic potential. They can be normalized by surrounding nontransformed cells by a process called contact normalization. Tumor cells need to override contact normalization to become malignant or metastatic. In this review, we discuss the role of Src in cell migration and contact normalization, with emphasis on Cas and Abl pathways. This paradigm illuminates several chemotherapeutic targets and may lead to the identification of new biomarkers and the development of effective anticancer treatments.

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“…The well-documented miRNAs, B22 nt long, serve as major regulators of gene expression and as intricate components of the cellular gene expression network, [2][3][4][5] and have identified critical roles for ncRNAs in cancer. 6,7 Furthermore, miRNAexpression profiling of human tumors has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. [7][8][9][10] In addition to the relatively welldescribed miRNAs, the growing knowledge of the mammalian non-coding transcriptome is revealing that the genome is also replete with long ncRNAs (lncRNAs).…”

mentioning

confidence: 99%

“…6,7 Furthermore, miRNAexpression profiling of human tumors has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. [7][8][9][10] In addition to the relatively welldescribed miRNAs, the growing knowledge of the mammalian non-coding transcriptome is revealing that the genome is also replete with long ncRNAs (lncRNAs). LncRNAs are mRNA-like transcripts ranging in length from 200 nt to B100 kb, yet are poorly conserved and do not function as templates for protein synthesis.…”

mentioning

confidence: 99%

The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

2013

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The conventional view of gene regulation in biology has centered around protein-coding genes via the central dogma of DNA-mRNA-protein. The discovery of thousands of long non-coding RNAs (lncRNAs) has certainly changed our view of the complexity of mammalian genomes and transcriptomes, as well as many other aspects of biology including transcriptional and posttranscriptional regulation of gene expression. Accumulating reports of misregulated lncRNA expression across numerous cancer types suggest that aberrant lncRNA expression may be a major contributor to tumorigenesis. Here, we summarize recent data about the biological characteristics of lncRNAs in cancer pathways. These include examples with a wide range of molecular mechanisms involved in gene regulation. We also consider the medical implications, and discuss how lncRNAs can be used for cancer diagnosis and prognosis, and serve as potential therapeutic targets. As more examples of regulation by lncRNA are uncovered, one might predict that the large transcripts will eventually rival small RNAs and proteins in their versatility as regulators of genetic information.

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MicroRNAs: Novel regulators in the hallmarks of human cancer

Cited by 403 publications

References 143 publications

The emerging role of miR‐19 in glioma

The emerging role of miR‐19 in glioma

Src Points the Way to Biomarkers and Chemotherapeutic Targets

The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

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