MicroRNAs Modulate the Pathogenesis of Alzheimer’s Disease: An In Silico Analysis in the Human Brain

Chiricosta, Luigi; Boccardi, Virginia; Mecocci, Patrizia; Bramantı, Placido; Mazzon, Emanuela

doi:10.3390/genes11090983

Cited by 15 publications

(6 citation statements)

References 71 publications

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“…In particular, miR-199 levels increase during early brain development and modulate extracellular signal-regulated kinase (ERK) [ 76 ]. Intriguingly, an in silico analysis reported that AD patients’ brains present upregulated levels of miR-199 [ 78 ]. Song et al, showed that miR-199 was involved in the development of AD by decreasing the expression of neuritin, a protein involved in neural development and plasticity [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

Martín-Martín

Pérez-García

Torrecilla-Parra

et al. 2022

Cells

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The evident implication of the insulin-degrading enzyme (IDE) in Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM), among its capacity to degrade insulin and amyloid-β peptide (Aβ), suggests that IDE could be an essential link in the relation between hyperinsulinemia, insulin resistance and AD. However, little is known about the cellular and molecular regulation of IDE expression, and even less has been explored regarding the post-transcriptional regulation of IDE, although it represents a great molecular target of interest for therapeutic treatments. We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway. Here, we explored whether other miRNAs as well as other post-transcriptional regulators, such as RNA binding proteins (RBP), could potentially participate in the regulation of IDE expression in vitro. Our data showed that in addition to miR-7, miR-125, miR-490 and miR-199 regulate IDE expression at the post-transcriptional level. Moreover, we also found that IDE contains multiple potential binding sites for several RBPs, and a narrow-down prediction analysis led us to speculate on a novel regulation of IDE by RALY and HuD. Taken together, these results demonstrate the novel players controlling IDE expression that could represent potential therapeutical targets to treat several metabolic diseases with a high impact on human health, including AD and T2DM.

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Section: Discussionmentioning

confidence: 99%

New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

Martín-Martín

Pérez-García

Torrecilla-Parra

et al. 2022

Cells

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“…Also, the results of this study demonstrated increased ReHo in the left BA21, which is located in the temporal cortex and involved in auditory and language processing. 37 Previous studies have demonstrated concurrent links between motor skills and auditory/language development in children. 38,39 Furthermore, the auditory/ language information has been shown to be involved in the regulation of sensorimotor function.…”

Section: Alteration Of Sensory Motor Related Brain Regionsmentioning

confidence: 99%

Altered Brain Function in Pediatric Patients With Complete Spinal Cord Injury: A Resting‐State Functional MRI Study

Wang,

Zheng

et al. 2023

Magnetic Resonance Imaging

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BackgroundInjury to the spinal cord of children may cause potential brain reorganizations, affecting their rehabilitation. However, the specific functional alterations of children after complete spinal cord injury (CSCI) remain unclear.PurposeTo explore the specific functional changes in local brain and the relationship with clinical characteristics in pediatric CSCI patients, clarifying the impact of CSCI on brain function in developing children.Study TypeProspective.SubjectsThirty pediatric CSCI patients (7.83 ± 1.206 years) and 30 age‐, gender‐matched healthy children as controls (HCs) (8.77 ± 2.079 years).Field Strength/Sequence3.0 T/Resting‐state functional MRI (rs‐fMRI) using echo‐planar‐imaging (EPI) sequence.AssessmentAmplitude of low‐frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were used to characterize regional neural function.Statistical TestsTwo‐sample t‐tests were used to compare the ALFF, fALFF, ReHo values of the brain between pediatric CSCI and HCs (voxel‐level FWE correction, P < 0.05). Spearman correlation analyses were performed to analyze the associations between the ALFF, fALFF, ReHo values in altered regions and the injury duration, sensory motor scores of pediatric CSCI patients (P < 0.05). Then receiver operating characteristic (ROC) analysis was conducted to identify possible sensitive imaging indicators for clinical therapy.ResultsCompared with HCs, pediatric CSCI showed significantly decreased ALFF in the right postcentral gyrus (S1), orbitofrontal cortex, and left superior temporal gyrus (STG), increased ALFF in bilateral caudate nucleus, thalamus, middle cingulate gyrus, and cerebellar lobules IV‐VI, and increased ReHo in left cerebellum Crus II and Brodmann area 21. The ALFF value in the right S1 negatively correlated with the pinprick and light touch sensory scores of pediatric CSCI. When the left STG was used as an imaging biomarker for pediatric CSCI, it achieved the highest area under the curve of 0.989.ConclusionsThese findings may provide potential neural mechanisms for sensory motor and cognitive‐emotional deficits in children after CSCI.Evidence Level2Technical EfficacyStage 5

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“…Thus, in general, given their important role in finely tuning post-transcriptional expression of proteins involved in synaptic plasticity, microRNAs might be central targets in the analysis/therapy of learning and memory processes, neurological diseases and dementia [ 56 , 225 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 ].…”

Section: Post-transcriptional Regulation and Synaptic Plasticity In T...mentioning

confidence: 99%

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals

Di Liegro,

Schiera,

Schirò

et al. 2024

Genes

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After many decades, during which most molecular studies on the regulation of gene expression focused on transcriptional events, it was realized that post-transcriptional control was equally important in order to determine where and when specific proteins were to be synthesized. Translational regulation is of the most importance in the brain, where all the steps of mRNA maturation, transport to different regions of the cells and actual expression, in response to specific signals, constitute the molecular basis for neuronal plasticity and, as a consequence, for structural stabilization/modification of synapses; notably, these latter events are fundamental for the highest brain functions, such as learning and memory, and are characterized by long-term potentiation (LTP) of specific synapses. Here, we will discuss the molecular bases of these fundamental events by considering both the role of RNA-binding proteins (RBPs) and the effects of non-coding RNAs involved in controlling splicing, editing, stability and translation of mRNAs. Importantly, it has also been found that dysregulation of mRNA metabolism/localization is involved in many pathological conditions, arising either during brain development or in the adult nervous system.

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MicroRNAs Modulate the Pathogenesis of Alzheimer’s Disease: An In Silico Analysis in the Human Brain

Cited by 15 publications

References 71 publications

New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

Altered Brain Function in Pediatric Patients With Complete Spinal Cord Injury: A Resting‐State Functional MRI Study

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals

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