MicroRNAs in Vascular Eye Diseases

Liu, Chi-Hsiu; Huang, Shuo; Britton, William; Chen, Jing

doi:10.3390/ijms21020649

Cited by 38 publications

(28 citation statements)

References 196 publications

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“…miR-27 promotes blood vessel development, particularly in the eye (Liu et al, 2020 ). miR-27 also plays an important role in mitochondrial dynamics as it inhibits degradation of damaged mitochondria by regulating PINK1 and also by inhibiting mitochondrial fission factor (MFF) expression, which increases mitochondrial membrane potential (Tak et al, 2014 ; Kim et al, 2016 ).…”

Section: Mir-7/mir-27/mir-31mentioning

confidence: 99%

miRNAs and Müller Glia Reprogramming During Retina Regeneration

Konar

Ferguson

Flickinger

et al. 2021

Front. Cell Dev. Biol.

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The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of key factors, altered chromatin accessibility, or inhibition of kinase/signaling cascades, a clearer picture of the key regulatory events that control retina regeneration is emerging. In all cases, Müller glia (MG) serve as an adult retinal stem cell that must be reprogrammed to allow for regeneration, with the end goal being to understand why regenerative pathways are blocked in mammals, but spontaneous in other vertebrates such as zebrafish. miRNAs have emerged as key gene regulatory molecules that control both development and regeneration in vertebrates. Here, we focus on a small subset of miRNAs that control MG reprogramming during retina regeneration and have the potential to serve as therapeutic targets for treatment of visual disorders and damage.

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Section: Mir-7/mir-27/mir-31mentioning

confidence: 99%

miRNAs and Müller Glia Reprogramming During Retina Regeneration

Konar

Ferguson

Flickinger

et al. 2021

Front. Cell Dev. Biol.

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“…Possibly, other regulators yet remain to be found. It is well recognized that all known regulators of gene expression may contribute to the etiology of diseases, including ocular diseases and specifically glaucoma (Acharya et al, 2011; Cisse, Bai, & Meng, 2018; N. Guo et al, 2019; F. Li, Wen, Zhang, & Fan, 2016; C. H. Liu, Huang, Britton, & Chen, 2020; Moazzeni et al, 2019; Ragusa et al, 2013; Romano et al, 2015; Tanaka et al, 2014; L. Zhang et al, 2019). Here, we have presented an up to date review of regulatory proteins and small RNA molecules that may have roles in glaucoma pathology.…”

Section: Resultsmentioning

confidence: 99%

“…Guo et al, 2019;F. Li, Wen, Zhang, & Fan, 2016;C. H. Liu, Huang, Britton, & Chen, 2020;Moazzeni et al, 2019;Ragusa et al, 2013;Romano et al, 2015;Tanaka et al, 2014;.…”

Section: Discussionmentioning

confidence: 99%

Insights into the regulatory molecules involved in glaucoma pathogenesis

Moazzeni

Khani

Elahi

2020

American J of Med Genetics Pt C

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Glaucoma is an important cause of irreversible blindness, characterized by optic nerve anomalies. Increased intraocular pressure (IOP) and aging are major risk factors. Retinal ganglion cells and trabecular meshwork cells are certainly involved in the etiology of glaucoma. Glaucoma is usually a complex disease, and various genes and functions may contribute to its etiology. Among these may be genes that encode regulatory molecules. In this review, regulatory molecules including 18 transcription factors (TFs), 195 microRNAs (miRNAs), 106 long noncoding RNAs (lncRNAs), and two circular RNAs (circRNAs) that are reasonable candidates for having roles in glaucoma pathogenesis are described. The targets of the regulators are reported. Glaucomarelated features including apoptosis, stress responses, immune functions, ECM properties, IOP, and eye development are affected by the targeted genes. The targeted genes that are frequently targeted by multiple regulators most often affect apoptosis and the related features of cell death and cell survival. BCL2, CDKN1A, and TP53 are among the frequent targets of three types of glaucoma-relevant regulators, TFs, miRNAs, and lncRNAs. TP53 was itself identified as a glaucoma-relevant TF. Several of the glaucoma-relevant TFs are themselves among frequent targets of regulatory molecules, which is consistent with existence of a complex network involved in glaucoma pathogenesis.

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“…Impaired or even a complete loss of miRNA activity can result in several defects and malfunctioning at both tissue and cell level ( Gurtner et al, 2016 ). Pathological implications of miRNA dysregulation have been described for retinal tissues, under either normal or pathological states (diabetes, neovascularization) ( Liu et al, 2020 ). The usefulness of miRNA, as diagnostic tool, has been prospected from experimental models of diabetic retinopathy.…”

Section: Dr and Novel Potential Players For Personalized Medicinementioning

confidence: 99%

Biomarkers of Neurodegeneration and Precision Therapy in Retinal Disease

et al. 2021

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Vision-threatening retinal diseases affect millions of people worldwide, representing an important public health issue (high social cost) for both technologically advanced and new-industrialized countries. Overall RD group comprises the retinitis pigmentosa, the age-related macular degeneration (AMD), the diabetic retinopathy (DR), and idiopathic epiretinal membrane formation. Endocrine, metabolic, and even lifestyles risk factors have been reported for these age-linked conditions that represent a “public priority” also in this COVID-19 emergency. Chronic inflammation and neurodegeneration characterize the disease evolution, with a consistent vitreoretinal interface impairment. As the vitreous chamber is significantly involved, the latest diagnostic technologies of imaging (retina) and biomarker detection (vitreous) have provided a huge input at both medical and surgical levels. Complement activation and immune cell recruitment/infiltration as well as detrimental intra/extracellular deposits occur in association with a reactive gliosis. The cell/tissue aging route shows a specific signal path and biomolecular profile characterized by the increased expression of several glial-derived mediators, including angiogenic/angiostatic, neurogenic, and stress-related factors (oxidative stress metabolites, inflammation, and even amyloid formation). The possibility to access vitreous chamber by collecting vitreous reflux during intravitreal injection or obtaining vitreous biopsy during a vitrectomy represents a step forward for an individualized therapy. As drug response and protein signature appear unique in each single patient, therapies should be individualized. This review addresses the current knowledge about biomarkers and pharmacological targets in these vitreoretinal diseases. As vitreous fluids might reflect the early stages of retinal sufferance and/or late stages of neurodegeneration, the possibility to modulate intravitreal levels of growth factors, in combination to anti-VEGF therapy, would open to a personalized therapy of retinal diseases.

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MicroRNAs in Vascular Eye Diseases

Cited by 38 publications

References 196 publications

miRNAs and Müller Glia Reprogramming During Retina Regeneration

miRNAs and Müller Glia Reprogramming During Retina Regeneration

Insights into the regulatory molecules involved in glaucoma pathogenesis

Biomarkers of Neurodegeneration and Precision Therapy in Retinal Disease

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