MicroRNAs in skin and wound healing

Banerjee, Jaideep; Chan, Yuk Cheung; Sen, Chandan K.

doi:10.1152/physiolgenomics.00157.2010

Cited by 125 publications

(96 citation statements)

References 166 publications

(170 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conditional deletion of genes encoding Dicer and DiGeorge syndrome critical region gene 8 (Dgcr8), key proteins involved in miRNA biogenesis, revealed important roles of miRNAs in mammalian skin development and function 21,22 . Furthermore, miRNAs are regulators of keratinocyte proliferation and differentiation in normal and wounded skin, as well as in autoimmune and chronic skin diseases [23][24][25] . Therefore, we decided to study the role of Nrf2 in the control of miRNA expression in the skin.…”

mentioning

confidence: 99%

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

et al. 2014

View full text Add to dashboard Cite

The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of microRNAs. On Nrf2 activation, expression of miR-29a and miR-29b increases in cultured human keratinocytes and in mouse epidermis. Chromatin immunoprecipitation identified the Mir29ab1 and Mir29b2c genes as direct Nrf2 targets in keratinocytes. While binding of Nrf2 to the Mir29ab1 gene activates expression of miR-29a and -b, the Mir29b2c gene is silenced by DNA methylation. We identified desmocollin-2 (Dsc2) as a major target of Nrf2-induced miR-29s. This is functionally important, since Nrf2 activation in keratinocytes of transgenic mice causes structural alterations of epidermal desmosomes. Furthermore, the overexpression of miR-29a/b or knockdown of Dsc2 impairs the formation of hyper-adhesive desmosomes in keratinocytes, whereas Dsc2 overexpression has the opposite effect. These results demonstrate that a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis.

show abstract

mentioning

confidence: 99%

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

et al. 2014

View full text Add to dashboard Cite

show abstract

“…For example, induction of miRNA-210 results in an impaired closure of ischemic wounds through a reduction in keratinocyte proliferation. 15,16 In hypoxic environments such as chronic ischemic wounds, the transcription factor hypoxia-inducible factor (HIF) is known to upregulate vascular endothelial growth factor (VEGF), stimulating angiogenesis and vasculogenesis. 17 However, studies have now also found that HIF is also responsible for the specific upregulation of miRNA-210 in response to hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Noncoding RNAs in Wound Healing: A New and Vast Frontier

Luan

Leavitt

et al. 2018

Advances in Wound Care

View full text Add to dashboard Cite

“…150 Recent studies suggested that miRNAs play important roles in wound healing, including regulating angiogenesis, reepithelialization, and wound remodeling. 151,152 Angiogenesis is critical for initiating wound healing and miRNAs have been shown as important angiogenic regulators. 153 In diabetic wounds, Chan et al showed that downregulation of miR-200b promoted angiogenesis and accelerated healing by desilencing GATA binding protein 2 and VEGF receptor 2.…”

Section: 81mentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

show abstract

MicroRNAs in skin and wound healing

Cited by 125 publications

References 166 publications

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

Noncoding RNAs in Wound Healing: A New and Vast Frontier

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Contact Info

Product

Resources

About