MicroRNAs in serum of Interstitial lung diseases patients

Shepelkova, Galina; Evstifeev, Vladimir; Zaytseva, Anna; Adamovskaya, Evgenia; Guskov, Alexander; Stepanyan, Igor E.; Shmelev, Evgeniy; Yeremeev, Vladimir

doi:10.1183/13993003.congress-2020.1082

Cited by 2 publications

(1 citation statement)

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“…In another study of ILD patients which included two cohorts of Hypersensitivity Pneumonitis and NSIP patients, miRNA pro ling of serum samples reveals a difference in the miRNA's expression of the two distinct groups. miR-375 and miR-193a were overexpressed in NSIP while miR-374a, miR-18a, miR-15a, and miR-106b were found upregulated in hypersensitivity pneumonitis patients [28].…”

Section: Mirnamentioning

confidence: 90%

Non-Coding RNA in Idiopathic Interstitial Pneumonia and Covid-19 Pulmonary Fibrosis

Ali

Singh

Alam

et al. 2022

Preprint

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Pulmonary fibrosis is the major manifestation of idiopathic interstitial pneumonia as well as post-COVID-19 complications. The pathogenesis of PF is a complex molecular process that involves many types of cells, proteins, genes, and regulatory elements. The non-coding RNA is the main regulatory element in this process which mainly includes; miRNA, circRNA, and lncRNA. These regulatory elements control the expression of many important genes and various pathways that are involved in the pathogenesis of pulmonary fibrosis. Identification and molecular mechanisms by which these non-coding RNA molecules works are very important because they do not only help to understand the molecular basis of the disease but could also serve as a potential diagnostic/prognostic marker as well as therapeutic targets. In this review, we have provided the latest findings and discussed the role of these regulatory elements in various biological processes and pathways involved in the pathogenesis of pulmonary fibrosis associated with IIPs and Covid-19.

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Section: Mirnamentioning

confidence: 90%

Non-Coding RNA in Idiopathic Interstitial Pneumonia and Covid-19 Pulmonary Fibrosis

Ali

Singh

Alam

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

et al. 2022

View full text Add to dashboard Cite

Pulmonary fibrosis is the key feature of majority of idiopathic interstitial pneumonias (IIPs) as well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a complex molecular process that involves myriad of cells, proteins, genes, and regulatory elements. The non-coding RNA mainly miRNA, circRNA, and lncRNA are among the key regulators of many protein coding genes and pathways that are involved in pulmonary fibrosis. Identification and molecular mechanisms, by which these non-coding RNA molecules work, are crucial to understand the molecular basis of the disease. Additionally, elucidation of molecular mechanism could also help in deciphering a potential diagnostic/prognostic marker as well as therapeutic targets for IIPs and post-COVID-19 pulmonary fibrosis. In this review, we have provided the latest findings and discussed the role of these regulatory elements in the pathogenesis of pulmonary fibrosis associated with Idiopathic Interstitial Pneumonia and Covid-19.

show abstract

MicroRNAs in serum of Interstitial lung diseases patients

Cited by 2 publications

References 0 publications

Non-Coding RNA in Idiopathic Interstitial Pneumonia and Covid-19 Pulmonary Fibrosis

Non-Coding RNA in Idiopathic Interstitial Pneumonia and Covid-19 Pulmonary Fibrosis

Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

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