MicroRNAs in Human Cancer

Farazi, Thalia A.; Hoell, Jessica I.; Morozov, Pavel; Tuschl, Thomas

doi:10.1007/978-94-007-5590-1_1

Cited by 616 publications

(522 citation statements)

References 200 publications

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“…Consequently, molecular mechanism studies concerning the development mechanisms of bladder cancer are urgent. microRNAs (miRNAs) are a subgroup of endogenous non-coding small RNAs that are 19-23 nucleotides in length and are involved in post-transcriptional regulation by targeting the 3'UTR of mRNA to affect biological processes (5)(6)(7)(8)). An increasing number of studies have shown that miRNAs act as a group of regulatory genes and participate in the development and progression of various diseases, such as the progression of tumorigenesis (6,(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Jia

Dou

2016

Oncology Reports

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Abstract. microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a member of the death effector domaincontaining protein family. First, we found that miR-24-3p was highly expressed and that DEDD was expressed at a low level in bladder cancer tissues compared with that in adjacent bladder tissues by qRT-PCR (P<0.0001). Second, we found that miR-24-3p promoted the proliferation ability of bladder cancer cells using the MTT assay and colony forming assay; and showed that miR-24-3p accelerated the migration and invasion of bladder cancer cells using migration and invasion assays (P<0.05). Moreover, miR-24-3p inhibited apoptosis of bladder cancer cells, as shown by flow cytometry (P<0.05). Western blot results demonstrated that miR-24-3p participated in autophagy of bladder cancer cells by DEDD. In addition, the tumor formation assay showed that miR-24-3p promoted the growth of bladder tumor in vivo. Furthermore, the luciferase reporter gene assay indicated that miR-24-3p suppressed DEDD gene transcription. Therefore, our study indicated that miR-24-3p promoted bladder cancer progression by inhibiting DEDD.

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Section: Introductionmentioning

confidence: 99%

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Jia

Dou

2016

Oncology Reports

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“…Thus, miRNAs have been identified as performing significant regulatory functions in various cellular, biological and pathological processes, including the differentiation, progression, apoptosis, and proliferation of cancer cells (Heneghan et al, 2010;Farooqi et al, 2014). These molecules characteristically moderate the translation and stability of mRNAs, including those genes that mediate processes in carcinogenesis, including the immune response, metabolism, inflammation, cell cycle control, viral replication, stem cell differentiation and human development (Farazi et al, 2013). miRNAs, known as gene regulators, expressed more than 30% of protein-coding genes in the human genome at the post transcriptional stage and simultaneously targeted multiple genes in the initiation and progression of human malignancies (Croce, 2009).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha¹,

Vijayarathna²,

Jothy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.

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“…Furthermore, accumulating evidence shows that miRNA constitutes one of the most important components of cells and is involved in nearly all biological processes, including cell growth,6 immune reaction,7 cell proliferation and differentiation,8, 9 cell development,6 cell cycle regulation,10 inflammation,11 apoptosis 12 and stress response 6, 13. It is also reported that the abnormality of miRNAs is connected with various human diseases, particularly cancers 14, 15. Identifying disease‐related miRNAs is an important biomedical research field, which benefits the understanding of disease pathogenesis at the molecular level and the design of molecular tools for disease diagnosis, treatment and prevention.…”

Section: Introductionmentioning

confidence: 99%

NDAMDA: Network distance analysis for MiRNA‐disease association prediction

Chen

Wang

Huang

2018

J Cellular Molecular Medi

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In recent years, microRNAs (miRNAs) are attracting an increasing amount of researchers’ attention, as accumulating studies show that miRNAs play important roles in various basic biological processes and that dysregulation of miRNAs is connected with diverse human diseases, particularly cancers. However, the experimental methods to identify associations between miRNAs and diseases remain costly and laborious. In this study, we developed a computational method named Network Distance Analysis for MiRNA‐Disease Association prediction (NDAMDA) which could effectively predict potential miRNA‐disease associations. The highlight of this method was the use of not only the direct network distance between 2 miRNAs (diseases) but also their respective mean network distances to all other miRNAs (diseases) in the network. The model's reliable performance was certified by the AUC of 0.8920 in global leave‐one‐out cross‐validation (LOOCV), 0.8062 in local LOOCV and the average AUCs of 0.8935 ± 0.0009 in fivefold cross‐validation. Moreover, we applied NDAMDA to 3 different case studies to predict potential miRNAs related to breast neoplasms, lymphoma, oesophageal neoplasms, prostate neoplasms and hepatocellular carcinoma. Results showed that 86%, 72%, 86%, 86% and 84% of the top 50 predicted miRNAs were supported by experimental association evidence. Therefore, NDAMDA is a reliable method for predicting disease‐related miRNAs.

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MicroRNAs in Human Cancer

Cited by 616 publications

References 200 publications

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

NDAMDA: Network distance analysis for MiRNA‐disease association prediction

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