MicroRNAs in erythropoiesis and red blood cell disorders

Mohammdai-asl, Javad; Ramezani, Abolfazl; Norozi, Fatemeh; Saki-Malehi, Amal; Asnafi, Ali Amin; Far, Mohammad Ali Jalali; Mousavi, Seyed Hadi; Saki, Najmaldin

doi:10.1007/s11515-015-1365-z

Cited by 6 publications

(7 citation statements)

References 111 publications

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“…Therefore, this molecule is a multifunctional miRNA. Increased level of miR-155 is associated with a reduction in the number of erythroid precursors, and circulating red cells (Mohammdai-asl et al, 2015;D. Zhang et al, 2017).…”

Section: The Role Of Pi3k Pathway In Autophagymentioning

confidence: 99%

PI3k/AKT signaling pathway: Erythropoiesis and beyond

Jafari

Ghadami

Dadkhah

et al. 2018

Journal Cellular Physiology

232

142

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Erythropoiesis is a multi-step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process can lead to hematologic disorders. PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, and differentiation. In this review, we focus on the role of PI3K/AKT pathway in erythropoiesis and discuss the function of some of the most important genes, transcription factors, and miRNAs that regulate different stages of erythropoiesis which play roles in differentiation and maturation of RBCs, prevention of apoptosis, and autophagy induction. Understanding the role of the PI3K pathway in erythropoiesis may provide new insights into diagnosing erythrocyte disorders.

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Section: The Role Of Pi3k Pathway In Autophagymentioning

confidence: 99%

PI3k/AKT signaling pathway: Erythropoiesis and beyond

Jafari

Ghadami

Dadkhah

et al. 2018

Journal Cellular Physiology

232

142

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“…They are also involved in other erythroid cell-associated functions, such as globin gene regulation [ 30 , 31 , 32 , 33 , 34 ], oxidant stress regulation [ 35 , 36 ], and iron absorption [ 37 ]. In a few red cell diseases, a correlation between the disease phenotype and expression levels of miRNAs has been reported [ 38 , 39 , 40 ]. Most of these studies were carried out in mouse and human erythroid cell lines and mouse primary erythroid cells.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis

Nath

Rayabaram

Ijee

et al. 2021

Cells

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MicroRNAs (miRNAs) are small non-coding RNAs, which play an important role in various cellular and developmental processes. The study of miRNAs in erythropoiesis is crucial to uncover the cellular pathways that are modulated during the different stages of erythroid differentiation. Using erythroid cells derived from human CD34+ hematopoietic stem and progenitor cells (HSPCs)and small RNA sequencing, our study unravels the various miRNAs involved in critical cellular pathways in erythroid maturation. We analyzed the occupancy of erythroid transcription factors and chromatin accessibility in the promoter and enhancer regions of the differentially expressed miRNAs to integrate miRNAs in the transcriptional circuitry of erythropoiesis. Analysis of the targets of the differentially expressed miRNAs revealed novel pathways in erythroid differentiation. Finally, we described the application of Clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) based editing of miRNAs to study their function in human erythropoiesis.

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“…Erythrocytes cannot synthesize miRNAs via the canonical pathway as, they are enucleated. They may retain miRNAs populations since enucleation (14). In addition, it has been observed that mature erythrocytes are proved as potential repositories of miRNAs in the circulating system (15).…”

Section: Introductionmentioning

confidence: 99%

“…miRNAs can affect erythropoiesis by down regulation of miR-221, -222, -150 and -155 from transition of reticulocytes to mature erythrocytes (16,17). miR-451, -144 are reported to be upregulated during maturation of erythrocytes by GATA-1 (14,15,18). miR-451 increases the activity of FOXO3-which is involved in the control of oxidative stress and promotes synthesis of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Functional prediction of human erythrocytic miR-451a on Plasmodium falciparum 3D7 transcriptome—an in-silico study

Joshi¹,

Patel²,

Pandya³

et al. 2021

ExRNA

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Background: Plasmodium falciparum (P. falciparum) is one of the deadliest species responsible for the major deaths related to malaria. Recently emerging research has focused on small noncoding RNAs especially mature microRNAs (miRNAs) (19-25 nts) which play regulatory role chiefly by targeting mRNAs' cleavage or translational repression. During infection, parasitic Plasmodium invades and takes command of the host cell for its survival and develops into its various life stages. Seeing that host, miRNAs considered as chief regulators of various physiological functions of the cell itself. During erythrocytic stages, possible interactions between the erythrocytic miRNAs and Plasmodium mRNAs may affect parasite biology and its survival inside the host cell. It has been also reported that during erythrocytic stages of P. falciparum, erythrocytic miRNAs may translocate into the parasite phosphorous vacuole, some of them may forming a chimera with Plasmodium mRNAs to get involved in post transcriptional regulation.Methods: In this study, one of the most abundant human erythrocytic miR-451a retrieved from miRbase and targeted on P. falciparum 3D7 transcriptome to find out the target genes and followed by annotation studies performed of targeted genes.Results: We identified crucial gene targets of P. falciparum using PSRNA target tool. Functional annotation of targeted genes and their protein products help us to understand the possible protein-protein interaction during the course of infection as well as analysis of their functions at molecular/cellular/biological level shows the significant contribution from the cytoskeletal genes which codes for the proteins like Plasmodium falciparum 3D7 erythrocyte membrane protein 1 (PfEMP1), rifin, etc. which are involved in the host membrane modifications.Conclusions: Computational approach to elucidate the erythrocytic microRNA (miRNA) targeted genes and their functional annotation studies will help to understand the possible interactions and miRNA regulatory network in malaria.

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MicroRNAs in erythropoiesis and red blood cell disorders

Cited by 6 publications

References 111 publications

PI3k/AKT signaling pathway: Erythropoiesis and beyond

PI3k/AKT signaling pathway: Erythropoiesis and beyond

Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis

Functional prediction of human erythrocytic miR-451a on Plasmodium falciparum 3D7 transcriptome—an in-silico study

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