MicroRNAs in endometriosis: biological function and emerging biomarker candidates†

Björkman, Sarah; Taylor, Hugh S.

doi:10.1093/biolre/ioz014

Cited by 69 publications

(65 citation statements)

References 147 publications

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“…Most studies have identified differential miRNA expression by comparing disease-free patients with those with endometriosis, and a number of studies have only analyzed the eutopic endometrium in a certain phase of the menstrual cycle (25)(26)(27). However, different endometriosis tissues, including those of endometrioma and peritoneal and ovarian endometriosis, express different profiles of miRNAs, and miRNA expression may or may not vary throughout the menstrual cycle phases (28).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of miR‑135a/b expression in endometriosis lesions

et al. 2019

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The pathogenesis of endometriosis is not clear; however, microRNAs (miRNAs/miRs) are involved in the pathogenesis. miRNAs are short noncoding RNAs involved in post-transcriptional regulation of gene expression by silencing the expression of target genes. The expression of miR-135a/b is associated with endometrial receptivity and implantation; the expression is also associated with the expression of certain genes, including homeobox protein Hox-A10 (HOXA-10). The present study investigated the expression of miR-135a/b in eutopic and ectopic endometrium tissues throughout the different phases of the menstrual cycle. Samples of ectopic endometriosis lesions and eutopic endometrium tissue from 23 patients who underwent laparoscopic surgery were obtained and analyzed. miRNA was extracted and the expression levels of miR-135a/b were determined by reverse transcription quantitative polymerase chain reaction assays using U6 as a housekeeping control. The expression levels of miR-135a and miR-135b in endometriosis lesions were decreased compared with the levels in endometrium tissue. However, miR-135a/b expression levels were increased in the secretory phase compared with the proliferative phase in endometriosis lesions. The increased expression of miR-135a/b during the secretory phase compared with the proliferative phase suggested that these genes serve a determinant role in the homeostasis of reproductive tissue. Therefore, the expression of genes may affect endometrial functioning, impairing embryo implantation.Abbreviations: miRNA, microRNA; HOXA10, homeobox protein Hox-A10; RT-qPCR, reverse transcription quantitative polymerase chain reaction; RNA, ribonucleic acid

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Section: Discussionmentioning

confidence: 99%

Evaluation of miR‑135a/b expression in endometriosis lesions

et al. 2019

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“…Several studies have illustrated the significant involvement of miRNAs in mammalian ovarian function and reproductive disorders (Santamaria and Taylor, 2014;Sørensen et al, 2014;Bjorkman and Taylor, 2019). The first evidence of the importance of miRNAs in mammalian reproduction was reported after the targeted deletion of enzymes that have a crucial role in miRNA biogenesis like DICER and AGO2 (Nagaraja et al, 2008;Gonzalez and Behringer, 2009;Pastorelli et al, 2009).…”

Section: The Role Of Mirnas In Ovarian Functionmentioning

confidence: 99%

“…Among them, miR-21 has been extensively studied in PCOS and may serve as predictive biomarker as its expression in GCs and follicular fluid was associated with different PCOS patient phenotypes (Naji et al, 2017) and its levels were increased in the serum of PCOS patients (Jiang et al, 2015). Several studies have also implicated miRNAs in the pathogenesis of endometriosis while others have suggested that miRNAs may be useful as diagnostic biomarkers or potential therapeutic targets in this condition (Bjorkman and Taylor, 2019). As an example,…”

Section: The Role Of Mirnas In Metabolic and Gynecological Diseasesmentioning

confidence: 99%

The role of microRNAs in ovarian function and the transition toward novel therapeutic strategies in fertility preservation: from bench to future clinical application

Alexandri

Daniel

Bruylants

et al. 2020

Human Reproduction Update

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BACKGROUND New therapeutic approaches in oncology have converted cancer from a certain death sentence to a chronic disease. However, there are still challenges to be overcome regarding the off-target toxicity of many of these treatments. Oncological therapies can lead to future infertility in women. Given this negative impact on long-term quality of life, fertility preservation is highly recommended. While gamete and ovarian tissue cryopreservation are the usual methods offered, new pharmacological-based options aiming to reduce ovarian damage during oncological treatment are very attractive. In this vein, advances in the field of transcriptomics and epigenomics have brought small noncoding RNAs, called microRNAs (miRNAs), into the spotlight in oncology. MicroRNAs also play a key role in follicle development as regulators of follicular growth, atresia and steroidogenesis. They are also involved in DNA damage repair responses and they can themselves be modulated during chemotherapy. For these reasons, miRNAs may be an interesting target to develop new protective therapies during oncological treatment. This review summarizes the physiological role of miRNAs in reproduction. Considering recently developed strategies based on miRNA therapy in oncology, we highlight their potential interest as a target in fertility preservation and propose future strategies to make the transition from bench to clinic. OBJECTIVE AND RATIONALE How can miRNA therapeutic approaches be used to develop new adjuvant protective therapies to reduce the ovarian damage caused by cytotoxic oncological treatments? SEARCH METHODS A systematic search of English language literature using PubMed and Google Scholar databases was performed through to 2019 describing the role of miRNAs in the ovary and their use for diagnosis and targeted therapy in oncology. Personal data illustrate miRNA therapeutic strategies to target the gonads and reduce chemotherapy-induced follicular damage. OUTCOMES This review outlines the importance of miRNAs as gene regulators and emphasizes the fact that insights in oncology can inspire new adjuvant strategies in the field of onco-fertility. Recent improvements in nanotechnology offer the opportunity for drug development using next-generation miRNA-nanocarriers. WIDER IMPLICATIONS Although there are still some barriers regarding the immunogenicity and toxicity of these treatments and there is still room for improvement concerning the specific delivery of miRNAs into the ovaries, we believe that, in the future, miRNAs can be developed as powerful and non-invasive tools for fertility preservation.

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“…response, and oncogenesis [179]. MicroRNAs play an important role in the initiation, progression and metastasis of OCs and may serve as potential emerging biomarkers of endometriosis [180]. Table 3 highlights the profiles of miRNAs in EE and ET of women with and without endometriosis and in EACs and their putative functional roles.…”

Section: Oncogenes and Tumor Suppressor Genesmentioning

confidence: 99%

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

Ghosh

Anupa

et al. 2019

COGO

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Endometriosis is an inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus primarily on pelvic organs and tissues. It affects up to 15% of women in the reproductive age group and is often associated with pelvic pain and subfertility. Different theories explain how retrograde menstruation gives rise to endometrial deposits at ectopic sites, and how several other factors are involved in the progression of the disease. Its final diagnosis is established through direct visualization at laparoscopy or surgery followed by histological confirmation. Available epidemiological reports along with histopathological observations and molecular studies shed interesting light on the pathogenetic basis of different variants of the disease like deep infiltrating endometriosis and ovarian endometriosis. Evidence also suggests that endometriosis is a neoplastic condition which serves as a precursor of ovarian and endometrial cancers. In the present review, we have attempted to take a stock of the current epidemiological and molecular knowledge regarding endometriosis associated cancers and develop a model of functional network with interactions among critical genomic factors regulating cellular processes leading to fibrotic reaction. It is being conjectured that cyclic bleeding associated with inflammatory and oxidative stress followed by repeated tissue injury and repair along with recurrent estrogenic stimulation and ovulatory events in the pelvic environment bring about the complex phenotype of atypical endometriosis and associated neoplasm with a trade-off malignant transformation in high risk population. Finally, we have presented an algorithm for pre-emptive monitoring and management of endometriosis-associated cancers.

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MicroRNAs in endometriosis: biological function and emerging biomarker candidates†

Cited by 69 publications

References 147 publications

Evaluation of miR‑135a/b expression in endometriosis lesions

Evaluation of miR‑135a/b expression in endometriosis lesions

The role of microRNAs in ovarian function and the transition toward novel therapeutic strategies in fertility preservation: from bench to future clinical application

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

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