MicroRNAs in adipose tissue: their role in adipogenesis and obesity

Hilton, Catriona; Neville, Matthew J.; Karpe, Fredrik

doi:10.1038/ijo.2012.59

Cited by 151 publications

(114 citation statements)

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“…Overexpression of miR-204 in MSCs promotes adipogenesis, whereas its inhibition favors osteogenesis [55,56]. The miR 17-92 cluster is highly expressed during clonal expansion in preadipocytes and enhances adipogenesis through inhibiting the tumor suppressor, Rb2/p130 during the early clonal expansion of preadipocytes [51,52].…”

Section: Role Of Micrornas In Adipogenesismentioning

confidence: 99%

Differential effects of dietary flavonoids on adipogenesis

et al. 2018

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Propose Obesity is a fast growing epidemic worldwide. During obesity, the increase in adipose tissue mass arise from two different mechanisms, namely, hyperplasia and hypertrophy. Hyperplasia which is the increase in adipocyte number is characteristic of severe obese patients. Recently, there has been much interest in targeting adipogenesis as therapeutic strategy against obesity. Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Methods Presently, we provide a review of key studies evaluating the effects of dietary flavonoids in different stages of adipocyte development with a particular emphasis on the investigations that explore the underlying mechanisms of action of these compounds in human or animal cell lines as well as animal models. Results Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Although most of the studies reveal anti-adipogenic effect of flavonoids, some flavonoids demonstrated proadipogenic effect in mesenchymal stem cells or preadipocytes. Conclusion The anti-adipogenic effect of flavonoids is mainly via their effect on regulation of several pathways such as induction of apoptosis, suppression of key adipogenic transcription factors, activation of AMPK and Wnt pathways, inhibition of clonal expansion, and cell-cycle arrest.

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Section: Role Of Micrornas In Adipogenesismentioning

confidence: 99%

Differential effects of dietary flavonoids on adipogenesis

et al. 2018

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“…MicroRNAs also act indirectly, eg, by first regulating transcription factors, which, in turn, control the expression of genes (6). Recent reports suggest that several miRNAs are involved in the pathophysiological processes of obesity, diabetes, and IR (5). However, there are currently not much data available on adiponectin regulation by miRNAs.…”

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confidence: 97%

“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally (4) and influence numerous cellular processes including adipocyte function (5). They either block translation or/and initiate mRNA degradation through complementary binding in the 3Ј-untranslated regions (UTRs) of target genes.…”

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confidence: 99%

MicroRNA-193b Controls Adiponectin Production in Human White Adipose Tissue

Belarbi

Mejhert

Lorente‐Cebrián

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…This has led many to study the role of microRNAs in adipogenesis (19,32), obesity, and insulin resistance (8,29,41,44). Insulin resistance is associated with altered expression of several microRNAs whose predicted target genes are involved in insulin signaling (INSR, PI3K, GLUT4) (8,44), metabolism (ADIPOR1) (29), and inflammation (ETS1) (37).…”

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confidence: 99%