MicroRNAs—getting the hang of it

Lund, Anders H.

doi:10.1038/cdd.2014.114

Cited by 9 publications

(8 citation statements)

References 14 publications

(8 reference statements)

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“…In the hypothalamus, cell type was less discernable. While resident immune cells, such as microglia, are principally thought to produce and elaborate inflammatory cytokines, several studies show that human neurons contain an inflammasome [61, 62]. In cultured primary cortical neurons, ethanol can induce caspase-1 activation and HMGB1 release [63].…”

Section: Discussionmentioning

confidence: 99%

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

et al. 2017

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Background Inflammation within the central nervous system (CNS) is frequently comorbid with anxiety. Importantly, the pro-inflammatory cytokine most commonly associated with anxiety is IL-1β. The bioavailability and activity of IL-1β is regulated by caspase-1-dependent proteolysis vis-a-vis the inflammasome. Thus, interventions regulating the activation or activity of caspase-1 should reduce anxiety especially in states that foster IL-1β maturation. Methods Male C57BL/6j, C57BL/6j mice treated with the capase-1 inhibitor biotin-YVAD-cmk, caspase-1 knockout (KO) mice and IL-1R1 KO mice were fasted for 24 hours or allowed ad libitum access to food. Immediately after fasting, caspase-1 activity was measured in brain region homogenates while activated caspase-1 was localized in the brain by immunohistochemistry. Mouse anxiety-like behavior and cognition were tested using the elevated zero maze and novel object/object location tasks, respectively. Results A 24 h fast in mice reduced the activity of caspase-1 in whole brain and in the prefrontal cortex, amygdala, hippocampus, and hypothalamus by 35%, 25%, 40%, 40%, and 40% respectively. A 24 h fast also reduced anxiety-like behavior by 40% and increased novel object and object location recognition by 21% and 31%, respectively. IL-1β protein, however, was not reduced in the brain by fasting. ICV administration of YVAD decreased caspase-1 activity in the prefrontal cortex and amygdala by 55%, respectively leading to a 64% reduction in anxiety like behavior. Importantly, when caspase-1 KO or IL1-R1 KO mice are fasted, no fasting-dependent reduction in anxiety-like behavior was observed. Conclusions Results indicate that fasting decrease anxiety-like behavior and improves memory by a mechanism tied to reducing caspase-1 activity throughout the brain.

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Section: Discussionmentioning

confidence: 99%

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

et al. 2017

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“…NOXA has been described as a particularly relevant pro-apoptotic BCL-2 family member in different cell types [ 36 ]. NOXA protein is induced in AML cells by HDAC inhibitors [ 37 , 38 ], MDM2 inhibition [ 39 ], Aurora B kinase inhibitors [ 40 ], inhibition of Nedd8 activating enzyme [ 41 , 42 ], hyperforin [ 43 ] and dihydroartemisinin [ 44 ]. Our results emphasize the role of NOXA in the induction of apoptosis in AML cells.…”

Section: Discussionmentioning

confidence: 99%

Targeting prohibitins induces apoptosis in acute myeloid leukemia cells

et al. 2016

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Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML.

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“…However, since neuroblasts in culture produce neurons, these experiments cannot rule out the possibility that neuronal progeny provide extrinsic feedback to regulate temporal transitions in neuroblasts. Indeed, a recent study reported that abdominal VNC neuroblasts undergo apoptosis in response to cues from progeny neurons [19]. Heterochronic transplants of older neuroblasts into younger hosts (or vice versa ), and in vitro cultures of isolated neuroblasts, where cell-contacts are prevented, will clarify whether intrinsic programs dominate over extrinsic cues.…”

Section: Temporal Patterning During Drosophila Neurogenesismentioning

confidence: 99%

Timing temporal transitions during brain development

Rossi

Fernandes

Desplan

2017

Current Opinion in Neurobiology

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During development a limited number of progenitors generate diverse cell types that comprise the nervous system. Neuronal diversity, which arises largely at the level of neural stem cells, is critical for brain function. Often these cells exhibit temporal patterning: they sequentially produce neurons of distinct cell fates as a consequence of intrinsic and/or extrinsic cues. Here, we review recent advances in temporal patterning during neuronal specification, focusing on conserved players and mechanisms in invertebrate and vertebrate models. These studies underscore temporal patterning as an evolutionarily conserved strategy to generate neuronal diversity. Understanding the general principles governing temporal patterning and the molecular players involved will improve our ability to direct neural progenitors towards specific neuronal fates for brain repair.

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MicroRNAs—getting the hang of it

Cited by 9 publications

References 14 publications

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

Targeting prohibitins induces apoptosis in acute myeloid leukemia cells

Timing temporal transitions during brain development

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