MicroRNAs expression pattern related to mast cell activation and angiogenesis in paraffin-embedded salivary gland tumors

Santos, Poliana Ramos Braga; Coutinho‐Camillo, Cláudia Malheiros; Soares, Fernando Augusto; Freitas, Valéria Souza; Vilas-Bôas, Deise Souza; Xavier, Flávia Caló Aquino; Rocha, Clarissa Araújo Gurgel; Araújo, Iguaracyra; Santos, Jean Nunes dos

doi:10.1016/j.prp.2017.10.012

Cited by 19 publications

(21 citation statements)

References 48 publications

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“…Zhang et al found that anti-miR-9 inhibitor suppressed invasion, metastasis and angiogenesis in neuroblastoma cell lines [48]. By contrast, Santos et al recently showed a significant negative correlation between miR-9 expression and microvessel density in salivary gland tumors[20]. Since miR-9 is secreted by fibroblasts the higher expression of miR-9 in our PAs may be explained by the rich extracellular matrix found in these tumors.…”

Section: Discussionmentioning

confidence: 80%

“…To understand the mechanisms involved in the molecular biology of SGTs, Santos et al compared the expression profiles of miRNAs in benign vs malignant tumors. Only miR-9 exhibited significantly increased expression in benign tumors, whereas miR-195 showed significantly decreased expression in malignant tumors[20].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, among significantly down-regulated miRNAs, miR-195 and miR-9 were reported to be involved in the interaction of tumor cells with the microenvironment [20,36,47].…”

Section: Discussionmentioning

confidence: 99%

“…However, conflicting results have been obtained[18,19]. Independent studies reported deregulation of miRNAs in SGTs and differential miRNA expression profile between malignant, benign SGTs and normal tissue, increasing interest in the study of miRNAs in these neoplasms[19,20].…”

Section: Introductionmentioning

confidence: 99%

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A microRNA signature for the differential diagnosis of salivary gland tumors

et al. 2019

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Salivary gland tumors (SGTs) are rare tumors of the head and neck with different clinical behavior. Preoperative diagnosis, based on instrumental and cytologic examinations, is crucial for their correct management. The identification of molecular markers might improve the accuracy of pre-surgical diagnosis helping to plan the proper treatment especially when a definitive diagnosis based only on cytomorphology cannot be achieved. miRNAs appear to be new promising biomarkers in the diagnosis and prognosis of cancer. Studies concerning the useful of miRNA expression in clinical decision-making regarding SGTs remain limited and controversial.The expression of a panel of 798 miRNAs was investigated using Nanostring technology in 14 patients with malignant SGTs (6 mucoepidermoid carcinomas, 4 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 ductal carcinoma, 1 cystadenocarcinoma and 1 adenocarcinoma) and in 10 patients with benign SGTs (pleomorphic adenomas). The DNA Intelligent Analysis (DIANA)-miRPath v3.0 software was used to determinate the miRNA regulatory roles and to identify the controlled significant Kyoto Encyclopedia of Genes and Genomes (KEGG) molecular pathways. Forty six miRNAs were differentially expressed (False Discovery Rate—FDR<0.05) between malignant and benign SGTs. DIANA miRPath software revealed enriched pathways involved in cancer processes as well as tumorigenesis, cell proliferation, cell growth and survival, tumor suppressor expression, angiogenesis and tumor progression. Interestingly, clustering analysis showed that this signature of 46 miRNAs is able to differentiate the two analyzed groups. We found a correlation between histological diagnosis (benign or malignant) and miRNA expression profile.The molecular signature identified in this study might become an important preoperative diagnostic tool.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

“…In our study, among significantly down-regulated miRNAs, miR-195 and miR-9 were reported to be involved in the interaction of tumor cells with the microenvironment [20,36,47].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A microRNA signature for the differential diagnosis of salivary gland tumors

et al. 2019

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“…Moreover, the antitumor effects of miR-195 in TSCC may be partially mediated by its inhibition of CCND1 and BCL-2 expression. 138 Based on the study by Santos et al, 139 miR-195, miR-17, miR-132 and miR-221 seem to play crucial roles as tumor suppressors in salivary function. However, Summerer et al 140 reported opposite data in a study of differential plasma miRNA expression between head and neck squamous cell cancer (HNSCC) patients and healthy individuals.…”

Section: Mir-195 In Various Cancersmentioning

confidence: 99%

MicroRNA-195: a review of its role in cancers

Liang

et al. 2018

OTT

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MicroRNAs (miRNAs) are small and highly conserved noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to the 3′-UTR of target mRNAs. Recently, increasing evidence has highlighted their profound roles in various pathological processes, including human cancers. Deregulated miRNAs function as either oncogenes or tumor suppressor genes in multiple cancer types. Among them, miR-195 has been reported to significantly impact oncogenicity in various neoplasms by binding to critical genes and signaling pathways, enhancing or inhibiting the progression of cancers. In this review, we focus on the expression of miR-195 in regulatory mechanisms and tumor biological processes and discuss the future potential therapeutic implications of diverse types of human malignancies.

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MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

Kimura,

Scarini,

Lavareze

et al. 2024

Head & Neck

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ObjectiveThis study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).Materials and MethodsWe analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.ResultsAcross the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.ConclusionThis study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.

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MicroRNAs expression pattern related to mast cell activation and angiogenesis in paraffin-embedded salivary gland tumors

Cited by 19 publications

References 48 publications

A microRNA signature for the differential diagnosis of salivary gland tumors

A microRNA signature for the differential diagnosis of salivary gland tumors

MicroRNA-195: a review of its role in cancers

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

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