MicroRNAs Associated with Androgen Receptor and Metastasis in Triple-Negative Breast Cancer
Mamoun Ahram,
Bayan Abu Alragheb,
Hassan Abushukair
et al.
Abstract:It is crucial to identify novel molecular biomarkers and therapeutic targets for triple-negative breast cancer (TNBC). The androgen receptor (AR) is a regulator of TNBC, acting partially via microRNA molecules (miRNAs). In this study, we used PCR arrays to profile the expression of 84 miRNAs in 24 TNBC tissue samples, which were equally classified according to AR expression and/or metastasis. Several bioinformatics tools were then utilized to determine the potentially affected protein targets and signaling pat… Show more
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