MicroRNAs as the Critical Regulators of Forkhead Box Protein Family in Pancreatic, Thyroid, and Liver Cancers

Akhlaghipour, Iman; Fanoodi, Ali; Zangouei, Amir Sadra; Taghehchian, Negin; Khalili-Tanha, Ghazaleh; Moghbeli, Meysam

doi:10.1007/s10528-023-10346-4

Cited by 12 publications

(1 citation statement)

References 139 publications

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“…Forkhead box (Fox) transcription factor, which contains a highly conserved DNA binding domain of ~100 amino acids consisting of three α helices, three β folds and two ring connections, plays critical roles in organ development, innate immunity, and other processes [1]. Based on phylogenetic analysis, Fox proteins are assigned to different subclasses and named "Fox, subclass N, member X" [2].…”

Section: Introductionmentioning

confidence: 99%

Functional Analysis of Forkhead Transcription Factor Fd59a in Spermatogenesis of <em>Drosophila melanogaster</em>

Tang,

Pei,

Xiao

et al. 2024

Preprint

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Spermatogenesis is critical for insect reproduction and is regulated by many different genes. In this study, we found that Forkhead transcription factor Fd59a functions as a key factor in spermatogenesis of Drosophila melanogaster. Fd59a contains a conversed Forkhead domain, and it is clustered to the FoxD subfamily with other FoxD members from some insect and vertebrate species. Mutation in Fd59a caused swelling in the apical region of the testis. More importantly, only a few mature sperm were present in the seminal vesicle of Fd59a mutant flies compared to the control flies, and the fertility of Fd59a2/2 mutant males was significantly lower than that of the control flies. Immunofluorescence staining showed that the homeostasis of testis stem cell niche in Fd59a2/2 mutant and Fd59a RNAi flies was disrupted, and apoptosis of sperm bundles was increased. Furthermore, results from RNA-sequencing and qRT-PCR suggest that Fd59a can regulate expression of genes related to reproductive process and cell death. Taken together, our results indicated that Fd59a plays a key role in the spermatogenesis of Drosophila.

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Section: Introductionmentioning

confidence: 99%