MicroRNAs as modulators of T cell functions in cancer

Emming, Stefan; Chirichella, Michele; Monticelli, Silvia

doi:10.1016/j.canlet.2018.05.019

Cited by 9 publications

(6 citation statements)

References 82 publications

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“…Moreover, previous reports have shown that miRNAs are differentially expressed in different T cell phenotypes upon T cell activation, implying that miRNA dynamics involves in T cell differentiation. Several excellent reviews have explored the relationship between miRNA dynamics and T cell differentiation ( Liang et al, 2015 ; Emming et al, 2018 ; Rodríguez-Galán et al, 2018 ). In this section, we discuss and summarize the latest research progress on how miRNA regulates T cell behaviors ( Table 1 ).…”

Section: Microrna Modulates Cd8 + T Cell Anti-tumor Responsesmentioning

confidence: 99%

The Interplay Between Epigenetic Regulation and CD8+ T Cell Differentiation/Exhaustion for T Cell Immunotherapy

Wong

Yin

Lam

et al. 2022

Front. Cell Dev. Biol.

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Effective immunotherapy treats cancers by eradicating tumourigenic cells by activated tumour antigen-specific and bystander CD8+ T-cells. However, T-cells can gradually lose cytotoxicity in the tumour microenvironment, known as exhaustion. Recently, DNA methylation, histone modification, and chromatin architecture have provided novel insights into epigenetic regulations of T-cell differentiation/exhaustion, thereby controlling the translational potential of the T-cells. Thus, developing strategies to govern epigenetic switches of T-cells dynamically is critical to maintaining the effector function of antigen-specific T-cells. In this mini-review, we 1) describe the correlation between epigenetic states and T cell phenotypes; 2) discuss the enzymatic factors and intracellular/extracellular microRNA imprinting T-cell epigenomes that drive T-cell exhaustion; 3) highlight recent advances in epigenetic interventions to rescue CD8+ T-cell functions from exhaustion. Finally, we express our perspective that regulating the interplay between epigenetic changes and transcriptional programs provides translational implications of current immunotherapy for cancer treatments.

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Section: Microrna Modulates Cd8 + T Cell Anti-tumor Responsesmentioning

confidence: 99%

The Interplay Between Epigenetic Regulation and CD8+ T Cell Differentiation/Exhaustion for T Cell Immunotherapy

Wong

Yin

Lam

et al. 2022

Front. Cell Dev. Biol.

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“…In a recent review, miR146a was shown to have an important role in the regulation of the T lymphocyte, where its absence results in cell proliferation and activation of the immune system. 14 Consequently, animals with a genetic deletion of miR146a developed chronic inflammatory diseases, with an increased production of myeloid cells, resulting in the development of sarcomas and lymphoma. Thus, miR146a has been characterized as a suppressive miR at least in the context of the immune system.…”

Section: Discussionmentioning

confidence: 99%

The role of single nucleotide polymorphisms of miRNAs 100 and 146a as prognostic factors for prostate cancer

et al. 2021

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Introduction: Prostate cancer has a high incidence in men and is the second cause of cancer death among americans male. microRNA (miR) is becoming a potential new prognostic factor for prostate cancer. Single nucleotide polymorphisms (SNPs) are common polymorphisms, characterized by a single exchange of nitrogen based in the DNA. This polymorphism is present in the miRs, altering their function. Objective: To evaluate the role of SNP rs1834306 of miR100 and rs2910164 of miR146a in the development and prognosis of prostate cancer. Methods: One hundred patients diagnosed with prostate cancer and 68 controls were selected. The identification of SNP was rated by quantitative polymerase chain reaction from blood samples, and the analysis was performed within the presence of SNP and the prognostic variables. Results: In the SNP rs1834306 (miR100), a smaller presence of the polymorphic homozygous genotype was identified in patients with PSA >10 ng/mL, ( P=0.03); when evaluating only the presence of the polymorphic allele G ( P=0.09) it was compared to the presence of the wild type allele A. Among the patients with prostate cancer, SNP rs2910164 (miR146A), the polymorphic allele was more frequent in patients with a Gleason score ⩾7 than in patients with a Gleason score <7, ( P=0.043). In patients with prostate cancer, miR100 was overexpressed in those with pT3 staging compared to pT2 and among those who had biochemical recurrence ( P = 0.004 and P = 0.011, respectively). Conclusions: SNP of miR146a acts as a poor prognostic factor (Gleason ⩾7), and the SNP of miR100 is linked to better prognostic data (PSA <10). MiR100 was overexpressed in prostate cancer with worse prognostic factors.

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“…In addition to its function as a tumor suppressor and/or oncogene [ 110 ], miR-146a was shown to play a critical role in regulating T cell functions by providing a general brake on proliferation and activation of immune cells and was able to limit immune responses linked to the TH1 and TH17 subsets. Mice lacking this miRNA developed more severe TH17 responses in murine models of autoimmunity, with increased production of IFN-γ and IL-17 and reduced secretion of IL-4 [ 111 ]. Furthermore, miR-146a is also a key regulator of Treg cell biology, as deficiency of miR-146a leads to impaired function of Treg cells and consequently to the breakdown of immunological tolerance and to the development of fatal immune-mediated lesions depending on IFN-γ.…”

Section: Discussionmentioning

confidence: 99%

Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs

Agha

Rouas

Najar

et al. 2020

IJMS

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Background: In addition to their roles in different biological processes, microRNAs in the tumor microenvironment appear to be potential diagnostic and prognostic biomarkers for various malignant diseases, including acute myeloid leukemia (AML). To date, no screening of circulating miRNAs has been carried out in the bone marrow compartment of AML. Accordingly, we investigated the circulating miRNA profile in AML bone marrow at diagnosis (AMLD) and first complete remission post treatment (AMLPT) in comparison to healthy donors (HD). Methods: Circulating miRNAs were isolated from AML bone marrow aspirations, and a low-density TaqMan miRNA array was performed to identify deregulated miRNAs followed by quantitative RT-PCR to validate the results. Bioinformatic analysis was conducted to evaluate the diagnostic and prognostic accuracy of the highly and significantly identified deregulated miRNA(s) as potential candidate biomarker(s). Results: We found several deregulated miRNAs between the AMLD vs. HD vs. AMLPT groups, which were involved in tumor progression and immune suppression pathways. We also identified significant diagnostic and prognostic signatures with the ability to predict AML patient treatment response. Conclusions: This study provides a possible role of enriched circulating bone marrow miRNAs in the initiation and progression of AML and highlights new markers for prognosis and treatment monitoring.

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MicroRNAs as modulators of T cell functions in cancer

Cited by 9 publications

References 82 publications

The Interplay Between Epigenetic Regulation and CD8+ T Cell Differentiation/Exhaustion for T Cell Immunotherapy

The Interplay Between Epigenetic Regulation and CD8+ T Cell Differentiation/Exhaustion for T Cell Immunotherapy

The role of single nucleotide polymorphisms of miRNAs 100 and 146a as prognostic factors for prostate cancer

Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs

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