MicroRNAs as Biomarkers for Ionizing Radiation Injury

Meng, Jian; Wang, Zhidong

doi:10.3389/fcell.2022.861451

Cited by 11 publications

(13 citation statements)

References 102 publications

(86 reference statements)

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“…We also noticed that miR-150 tended to be highly expressed in the RT response samples, implying it may play a role in radiosensitivity. Previous report showed that the expression of miR-150 decreased significantly in serum after irradiation in animal studies (Jia and Wang, 2022). Recently, miR-150-5p were confirmed to target ZEB1 and caused mRNA degradation, thus blocking EMT (Lu et al, 2017).…”

Section: Discussionmentioning

confidence: 94%

Improving the prediction for the response to radiotherapy of clinical tumor samples by using combinatorial model of MicroRNA expression

Tang

et al. 2022

Front. Genet.

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Purpose: Radiation therapy (RT) is one of the main treatments for cancer. The response to radiotherapy varies widely between individuals and some patients have poor response to RT treatment due to tumor radioresistance. Stratifying patients according to molecular signatures of individual tumor characteristics can improve clinical treatment. In here, we aimed to use clinical and genomic databases to develop miRNA signatures that can predict response to radiotherapy in various cancer types.Methods: We analyzed the miRNAs profiles using tumor samples treated with RT across eight types of human cancers from TCGA database. These samples were divided into response group (S, n = 224) and progressive disease group (R, n = 134) based on RT response of tumors. To enhance the discrimination for S and R samples, the predictive models based on binary logistic regression were developed to identify the best combinations of multiple miRNAs.Results: The miRNAs differentially expressed between the groups S and R in each caner type were identified. Total 47 miRNAs were identified in eight cancer types (p values <0.05, t-test), including several miRNAs previously reported to be associated with radiotherapy sensitivity. Functional enrichment analysis revealed that epithelial-to-mesenchymal transition (EMT), stem cell, NF-κB signal, immune response, cell death, cell cycle, and DNA damage response and DNA damage repair processes were significantly enriched. The cancer-type-specific miRNA signatures were identified, which consist of 2-13 of miRNAs in each caner type. Receiver operating characteristic (ROC) analyses showed that the most of individual miRNAs were effective in distinguishing responsive and non-responsive patients (the area under the curve (AUC) ranging from 0.606 to 0.889). The patient stratification was further improved by applying the combinatorial model of miRNA expression (AUC ranging from 0.711 to 0.992). Also, five miRNAs that were significantly associated with overall survival were identified as prognostic miRNAs.Conclusion: These mRNA signatures could be used as potential biomarkers selecting patients who will benefit from radiotherapy. Our study identified a series of miRNA that were differentially expressed between RT good responders and poor responders, providing useful clues for further functional assays to demonstrate a possible regulatory role in radioresistance.

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Section: Discussionmentioning

confidence: 94%

Improving the prediction for the response to radiotherapy of clinical tumor samples by using combinatorial model of MicroRNA expression

Tang

et al. 2022

Front. Genet.

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“…Increased attention to miRNAs in radiation biology is associated with the search for molecular diagnostic biomarkers to assess the level of IR-induced damage to organisms, including radiation-related premature cellular senescence ( Table 3 ) [ 211 ].…”

Section: Radiation-induced Cellular Senescencementioning

confidence: 99%

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Ibragimova,

Kussainova,

Aripova

et al. 2024

Cells

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This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure.

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“…MicroRNAs (miRNAs) are highly conserved, non-coding RNA fragments composed of 19–25 nucleotides that negatively regulate ~ 30% of human gene expression by binding to messenger RNA [ 72 , 73 ]. A number of miRNAs have been linked to non-cancer treatment-induced cardiac dysfunction, including cardiac hypertrophy (e.g., miR-1, miR-133a), fibrosis (e.g., miR-21), coronary artery disease (e.g., miR-624, miR-340), and chronic heart failure (miR-221, miR-21, miR-409-5p, miR-376a, miR-154) [ 74 ].…”

Section: Advances In Biomarkersmentioning

confidence: 99%

Advances in Screening for Radiation-Associated Cardiotoxicity in Cancer Patients

Schiffer,

Pedersen,

Lui

et al. 2023

Curr Cardiol Rep

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Purpose of Review Radiation is foundational to the treatment of cancer and improves overall survival. Yet, it is important to recognize the potential cardiovascular effects of radiation therapy and how to best minimize or manage them. Screening—both through imaging and with biomarkers—can potentially identify cardiovascular effects early, allowing for prompt initiation of treatment to mitigate late effects. Recent Findings Cardiac echocardiography, magnetic resonance imaging (MRI), computed tomography, and measurements of troponin and natriuretic peptides serve as the initial screening tests of choice for RICD. Novel imaging applications, including positron emission tomography and specific MRI parameters, and biomarker testing, including myeloperoxidase, growth differentiation factor 15, galectin 3, micro-RNA, and metabolomics, hold promise for earlier detection and more specific characterization of RICD. Summary Advances in imaging and novel applications of biomarkers have potential to identify subclinical RICD and may reveal opportunities for early intervention. Further research is needed to elucidate optimal imaging screening modalities, biomarkers, and surveillance strategies.

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MicroRNAs as Biomarkers for Ionizing Radiation Injury

Cited by 11 publications

References 102 publications

Improving the prediction for the response to radiotherapy of clinical tumor samples by using combinatorial model of MicroRNA expression

Improving the prediction for the response to radiotherapy of clinical tumor samples by using combinatorial model of MicroRNA expression

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Advances in Screening for Radiation-Associated Cardiotoxicity in Cancer Patients

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