MicroRNAs and the hallmarks of cancer

Dalmay, Tamás; Edwards, Dylan R.

doi:10.1038/sj.onc.1209911

Cited by 321 publications

(222 citation statements)

References 40 publications

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“…74 The first genome-wide profiling of miRNAs in breast cancer 75 identified 29 differentially expressed candidate miRNAs, of which 15 distinguished between breast cancer and normal breast tissue. In a bioinformatic analysis, Dalmay and Edwards 76 proposed potential miRNA target sites on 3'UTR sequences of genes that are involved in metastasis and that underlie the morphological changes associated with malignancy in the microenvironment.…”

Section: Epigenetic Control Of Tumor Developmentmentioning

confidence: 99%

Tumor microenvironment and breast cancer progression

Artacho-Cordón

Artacho‐Cordón

Ríos‐Arrabal

et al. 2012

Cancer Biology & Therapy

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Section: Epigenetic Control Of Tumor Developmentmentioning

confidence: 99%

Tumor microenvironment and breast cancer progression

Artacho-Cordón

Artacho‐Cordón

Ríos‐Arrabal

et al. 2012

Cancer Biology & Therapy

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“…Recent studies have implicated deregulated miRNA expression in EMT [119], as well as in the development and progression of various cancers [120,121]. One of the first characterized miRNA families relevant in carcinogenesis was the miR-17-92 cluster, also known as onco-miR-17-92 [122].…”

Section: Emt and Mirna Regulationmentioning

confidence: 99%

The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

Heinrich

Walser

Krysan

et al. 2011

Cancer Microenvironment

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The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis.Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.

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“…Identification of the molecular alterations involved in the pathogenesis of GC may help with the developing diagnostic markers that aid therapeutic intervention (Motoyama et al, 2008;Lo et al, 2009). MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of translation and in the degradation of target mRNAs (Dalmay and Edwards, 2006;Bartel, 2009). Since a miRNA is able to regulate hundreds of genes (Selbach et al, 2008), it is thought that miRNAs may be involved in the regulation of expression of up to 30% of human genes (Petrocca et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

et al. 2011

Oncogene

101

100

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MicroRNAs (miRNAs) are endogenous non-coding RNAs that are known to be involved in the pathogenesis of tumors. Gastric carcinoma (GC) is a common malignancy worldwide. The aim of this study was the identification of the expression signature and functional roles of aberrant miRNAs in GC. Initial screening established a profile of aberrantly expressed miRNAs in tumors. miR-370 was confirmed to be overexpressed in GC tissues. Higher expression of miR-370 in GC tissues was associated with more advanced nodal metastasis and a higher clinical stage compared with controls. In addition, significantly higher level of miR-370 was noted in the plasma of GC patients compared with controls. Patients having more invasive or advanced tumors also exhibited a higher plasma level of miR-370. In vitro assays indicated that exogenous miR-370 expression enhanced the oncogenic potential of GC cells. The AGS-GFPM2 cells with exogenous miR-370 expression also exhibited enhanced abdominal metastatic dissemination in nude mice. Reporter assays confirmed that miR-370 targeted predicted sites in 3 0 UTR of transforming growth factor-b receptor II (TGFb-RII) gene. The exogenous miR-370 expression decreased TGFb-RII expression and the phosphorylation of Smad3 elicited by TGFb1. The TGFb1-mediated repression in cell migration was reverted by exogenous miR-370 expression. A reverse correlation between miR-370 and TGFb-RII expression was noted in GC tissues. This study concludes that miR-370 is a miRNA that is associated with GC progression by downregulating TGFb-RII. The miRNA expression profile described in this study should contribute to future studies on the role of miRNAs in GC.

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MicroRNAs and the hallmarks of cancer

Cited by 321 publications

References 40 publications

Tumor microenvironment and breast cancer progression

Tumor microenvironment and breast cancer progression

The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

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