MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy

Mohammadi, Amir Hossein; Seyedmoalemi, Seyedvahid; Moghanlou, Mahsa; Akhlagh, Seyed Amirreza; Talaei, Sayyed Alireza; Hamblin, Michael R.; Jafari, Ameneh; Mirzaei, Hamed

doi:10.1007/s12035-022-02907-2

Cited by 9 publications

(5 citation statements)

References 186 publications

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“…Previous research suggested that miR-134, miR-132, and miR-124 play roles in improving the cognitive and memory functions following the onset of depression caused by enhanced synaptic plasticity. Among them, miR-134 was found to be involved in SIRT1-mediated BDNF and CREB expression [45]. miR-134 is a downstream molecule of SIRT1 that can be negatively regulated by SIRT1 [46].…”

Section: Sirt1 Regulates Depression By Mediating Neurogenesismentioning

confidence: 99%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. Exercise is an important means to improve energy metabolism and depression, but it remains to be established how SIRT1 acts during exercise and improves depression. By induction and analysis, SIRT1 can be activated by exercise and then improve the function of the hypothalamic–pituitary–adrenal (HPA) axis by upregulating brain-derived neurotrophic factors (BDNF), inhibit the inflammatory response (suppression of the NF-κB and TNF-α/indoleamine 2,3-dioxygenase (IDO)/5-Hydroxytryptamine (5-HT) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (IGF-1) and growth-associated protein-43 (GAP-43) pathways, etc.), thereby improving depression. The present review gives a summary and an outlook based on this finding and makes an analysis, which will provide a new rationale and insight for the mechanism by which exercise improves depression.

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Section: Sirt1 Regulates Depression By Mediating Neurogenesismentioning

confidence: 99%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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“…[ 14 ] In addition, as the developing brain is highly plastic, breast milk exosomal miRNAs significantly impact brain development. [ 15–18 ] In summary, these findings suggest that breast milk exosomal miRNAs play a unique role in brain development.…”

Section: Introductionmentioning

confidence: 85%

Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment

Ma,

Huo,

Tang

et al. 2024

Molecular Nutrition Food Res

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ScopeThis study investigates the exosomal microRNA (miRNA) profiles of term and preterm breast milk, including the most abundant and differentially expressed (DE) miRNAs, and their impact on neurodevelopment in infants.Methods and ResultsMature milk is collected from the mothers of term and preterm infants. Using high‐throughput sequencing and subsequent data analysis, exosomal miRNA profiles of term and preterm human breast milk (HBM) are acquired and it is found that the let‐7 and miR‐148 families are the most abundant miRNAs. Additionally, 23 upregulated and 15 downregulated miRNAs are identified. MiR‐3168 is the most upregulated miRNA in preterm HBM exosome, exhibiting targeting activity toward multiple genes involved in the SMAD and MAPK signaling pathways and playing a crucial role in early neurodevelopment. Additionally, the effects of miR‐3168 on neurodevelopment is confirmed and it is determined that it is an essential factor in the differentiation of neural stem cells (NSCs).ConclusionThis study demonstrates that miRNA expression in breast milk exosomes can be influenced by preterm delivery, thereby potentially impacting neurodevelopment in preterm infants.

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“…The presence of miRNA precursors and the Dicer enzyme, crucial for RNA processing, has been noted in dendritic and axonal areas [ 50 , 52 , 53 , 54 ]. The co-existence of pre-miRNAs and Dicer in these areas implies a mechanism that ensures miRNA specificity and rapid conversion to mature forms as required [ 55 , 56 ]. Emerging research further hints that synapses may actively participate in transforming precursor miRNAs into mature forms, possibly influenced by NMDA receptor activity [ 52 , 57 , 58 ].…”

Section: Role Of Mirnas In Neurobiologymentioning

confidence: 99%

Clinical Insights into MicroRNAs in Depression: Bridging Molecular Discoveries and Therapeutic Potential

Kaurani

2024

IJMS

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Depression is a major contributor to the overall global burden of disease. The discovery of biomarkers for diagnosis or prediction of treatment responses and as therapeutic agents is a current priority. Previous studies have demonstrated the importance of short RNA molecules in the etiology of depression. The most extensively researched of these are microRNAs, a major component of cellular gene regulation and function. MicroRNAs function in a temporal and tissue-specific manner to regulate and modify the post-transcriptional expression of target mRNAs. They can also be shuttled as cargo of extracellular vesicles between the brain and the blood, thus informing about relevant mechanisms in the CNS through the periphery. In fact, studies have already shown that microRNAs identified peripherally are dysregulated in the pathological phenotypes seen in depression. Our article aims to review the existing evidence on microRNA dysregulation in depression and to summarize and evaluate the growing body of evidence for the use of microRNAs as a target for diagnostics and RNA-based therapies.

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MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy

Cited by 9 publications

References 186 publications

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment

Clinical Insights into MicroRNAs in Depression: Bridging Molecular Discoveries and Therapeutic Potential

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