MicroRNAs and Inflammation in Colorectal Cancer

Josse, Claire

doi:10.1007/978-3-319-42059-2_3

Cited by 24 publications

(21 citation statements)

References 106 publications

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“…These non-coding RNAs are classified, based on their length, into small non-coding RNAs (<200 nucleotides), including miRNA, and long non-coding RNA (>200 nucleotides), including nuclear paraspeckle assembly transcript 1 ( 42 , 43 ). A number of non-coding RNAs have potential transcriptional, post-transcriptional and epigenetic regulatory functions, and are often dysregulated in many types of disease including cancer ( 44 – 47 ). miRNAs (18–25 nucleotides) are the most studied class of non-coding RNAs and post-transcriptionally regulate mRNA stability and translation ( 48 ).…”

Section: Role Of Mirnas In Cancermentioning

confidence: 99%

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)

et al. 2017

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Ubiquitin-like containing plant homeodomain and RING finger domains 1 (UHRF1) is an anti-apoptotic protein involved in the silencing of several tumor suppressor genes (TSGs) through epigenetic modifications including DNA methylation and histone post-translational alterations, and also epigenetic-independent mechanisms. UHRF1 overexpression is observed in a number of solid tumors and hematological malignancies, and is considered a primary mechanism in inhibiting apoptosis. UHRF1 exerts its inhibitory activity on TSGs by binding to functional domains and therefore influences several epigenetic actors including DNA methyltransferase, histone deacetylase 1, histone acetyltransferase Tat-interacting protein 60 and histone methyltransferases G9a and Suv39H1. UHRF1 is considered to control a large macromolecular protein complex termed epigenetic code replication machinery, in order to maintain epigenetic silencing of TSGs during cell division, thus enabling cancer cells to escape apoptosis. MicroRNAs (miRNAs) are able to regulate the expression of its target gene by functioning as either an oncogene or a tumor suppressor. In the present review, the role of tumor suppressive miRNAs in the regulation of UHRF1, and the importance of targeting the microRNA/UHRF1 pathways in order to induce the reactivation of silenced TSGs and subsequent apoptosis are discussed.

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Section: Role Of Mirnas In Cancermentioning

confidence: 99%

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)

et al. 2017

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“…Based on this research (Bachmayr-Heyda et al, 2015), some circRNAs were detected and the results showed that hsa_circ_0020397 was highly expressed in CRC cells. Subsequently, abnormal miRNA expression was found to be related to the occurrence, development and prognosis of CRC (Josse and Bours, 2016;Yamamoto and Mori, 2016). Using common bioinformatic algorithms (miRanda and RNAhybrid 2.2), miR-138 was predicted to have multiple binding sites on hsa_circ_0020397.…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR‐138 targets TERT and PD‐L1

Zhang

Wang

2017

Cell Biology International

199

154

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Colorectal cancer (CRC) is a common human gastrointestinal cancer, and recent studies indicate that circular RNA (circRNA) may regulate cancer development. In this study, we assess the role of circRNA specifically in colorectal cancer. Our quantitative PCR assays demonstrate an upregulation of the circRNA has_circ_0020397 and a downregulation of miR-138 in CRC cells, as well as a negative correlation between these two. Using a dual-luciferase reporter assay, we show evidence of miR-138-binding sites on hsa_circ_0020397, and that overexpression of hsa_circ_0020397 could inhibit the downregulation of luciferase activity by miR-138. Although hsa_circ_0020397 did not influence miR-138 expression per se, has_circ_0020397 did inhibit miR-138 activity, as examined via the expression of miR-138 targets telomerase reverse transcriptase (TERT) and programmed death-ligand 1 (PD-L1). Control treatments with plasmids overexpressing linear hsa_circ_0020397 did not have these effects. Hsa_circ_0020397 promoted cell viability and invasion of CRC cells and inhibited their apoptosis, whereas miR-138 had the opposite effect. Nevertheless, hsa_circ_0020397 antagonized miR-138 suppression of cell growth. When TERT or PD-L1 expression was suppressed with siRNAs, the above functions of hsa_circ_0020397 were attenuated, suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR-138 target genes. These findings support the role of circRNA in CRC pathogenesis.

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“…Moreover, one single miRNA effect lots of genes together, suggesting that they have the ability to control complex signal pathways including CRI. Lots of reports investigated the role of miRNAs in CRI, but studies of miRNAs in CRI in EC are quite limited [ 23 , 24 ]. Our previous study found that miR-302b was a potential molecular marker and inhibited proliferation by inducing apoptosis and repressed invasion potentially by targeting ErbB4 in ESCC [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

miR-302b inhibits cancer-related inflammation by targeting ERBB4, IRF2 and CXCR4 in esophageal cancer

Zhang

Cui

et al. 2017

Oncotarget

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Cancer related inflammation (CRI) plays an important role in the development of esophageal cancer (EC), and the target gene analysis shows that miR-302b potential target genes closely correlated to CRI important signaling pathways. The present study was to evaluate the inhibition of miR-302b on CRI in EC and its mechanism. We found that the expression levels of miR-302b in EC cells were lower than that in Het-1A cells, while TE11 with the lowest expression and OE33 with the highest. Inflammatory stimuli at 48 h significantly reduced expression of miR-302b in EC cells, but had no effect in Het-1A. After up-regulation of miR-302b in TE11 and down-regulation of miR-302b in OE33, it was found that miR-302b reduced CRI key transcription factors and representative cytokines. Then, over-expressed of miR-302b significantly altered potential target genes protein expressions and there was a negative correlation between miR-302b and potential target genes protein expressions (ERBB4, IRF2 and CXCR4) in EC tissues. Then reporter gene analysis revealed that miR-302b post-transcriptionally regulated expression of target genes by specific area of 3′-UTR. Transfected by target genes shRNA plasmids together could get the same effects of miR-302b on protein expression of CRI key transcription factors. Furthermore, miR-302b was able to repress tumor growth and transcription factors protein expression in vivo. These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC.

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MicroRNAs and Inflammation in Colorectal Cancer

Cited by 24 publications

References 106 publications

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)

Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR‐138 targets TERT and PD‐L1

miR-302b inhibits cancer-related inflammation by targeting ERBB4, IRF2 and CXCR4 in esophageal cancer

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