MicroRNAs and human diseases: diagnostic and therapeutic potential

Maqbool, Raihana; Hussain, Mahboob Ul

doi:10.1007/s00441-013-1787-3

Cited by 54 publications

(47 citation statements)

References 111 publications

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“…Over 1,000 miRNAs have been identified in the human genome. They bind to the 3'-untranslated region (3'-UTR) of specific target genes and regulate expression of those genes by promoting degradation of transcribed mRNAs or inhibiting their translation (4,5). Several studies indicate that miRNAs are key regulators of cell growth and differentiation, carcinogenesis, rheumatoid arthritis (RA), and inflammation (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

et al. 2014

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Periodontitis is a chronic inflammatory disease caused by specific bacteria and viruses. Local, systemic, and environmental factors affect the rate of disease progression. Immune responses to bacterial products, and the subsequent production of inflammatory cytokines, are crucial in the destruction of periodontal tissue. MicroRNAs (miRNAs) are a class of small RNAs that control various cell processes by negatively regulating protein-coding genes. In this study, we compared miRNA expression in inflamed and noninflamed gingival tissues from Japanese dental patients. Total RNAs were isolated from inflamed and noninflamed gingival tissues. miRNA expression profiles were examined by an miRNA microarray, and the data were analyzed by GeneSpring GX, Ingenuity Pathways Analysis, and the TargetScan databases. Observed miRNA expression levels in inflamed gingiva were confirmed by real-time PCR. The three most overexpressed (by >2.72-fold) miRNAs were hsa-miR-150, hsa-miR-223, and hsa-miR-200b, and the three most underexpressed (by <0.39-fold) miRNAs were hsa-miR-379, hsa-miR-199a-5p, and hsa-miR-214. In IPA analysis, hsa-miR-150, hsa-miR-223, and hsa-miR-200b were associated with inflammatory disease, organismal injury, abnormalities, urological disease, and cancer.

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Section: Introductionmentioning

confidence: 99%

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

et al. 2014

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“…Intronic miRNAs share mutual promoters with genes wherein they are integrated. After being produced as a single transcript, an intronic miRNA is processed from introns sequences (8). Another category of RNA molecules is represented by miRNAs generated by entire intron sequences.…”

Section: Microrna Biogenesis and Functionmentioning

confidence: 99%

“…Another category of RNA molecules is represented by miRNAs generated by entire intron sequences. These miRNAs are known as mirtrons (8)(9)(10).…”

Section: Microrna Biogenesis and Functionmentioning

confidence: 99%

“…miRISC can perform two alternative silencing mechanisms: it can inhibit the translation of mRNA or, induce the mRNA degradation. The nature of control adopted by miRISC depends on whether the sequence of the miRNA-loaded in the complex shows partial or full complementarity with the sequence of the target mRNA: sequences that match only partially lead to repression of the translation, while a sequence perfect matching triggers mRNA degradation (8,12).…”

Section: Microrna Biogenesis and Functionmentioning

confidence: 99%

“…Also, genetic mutation, as well as epigenetic modification of miRNAs genes, have been correlated with cancer (8).…”

Section: Micrornas and Cancermentioning

confidence: 99%

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