MicroRNAs and head and neck cancer: Reviewing the first decade of research

Sethi, Neeraj; Wright, Alexander; Wood, Henry M.; Rabbitts, Pamela

doi:10.1016/j.ejca.2014.07.012

Cited by 71 publications

(75 citation statements)

References 162 publications

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“…miRNA-21 in head and neck SCC has been shown to regulate a large number of oncogenic and tumor suppressor targets, including Ras, PDCD4, PTEN, RECK, and HNRPK, and its overexpression has been associated with poor prognosis [38]. Deregulated miRNAs in head and neck SCCs also include: miRNA-155, which downregulates the CDC73 gene and suppresses the cytokine signaling 1 (SOCS1)-STAT3 pathway; the cluster miR-106b, -93 and -25, which targets the p21/CDKN1A pathway; miRNA-130b, regulating the tumor suppressor gene RUNX3, and miR-31 activating the HIF pathway in some cancer types [39]. Moreover, several miRNAs with tumor suppressor activity have also been found deregulated in head and neck cancers.…”

Section: Role Of Mirna In Oropharynx Tumorsmentioning

confidence: 99%

“…Let-7, whose reduced expression is associated with a poor prognosis, negatively regulates the KRAS oncogene. Other miRNAs with potentially tumor suppressor activities include miRNA-1, -153, -29s, -24, -27a, -34a, -101, -107, -124, -126, -133a, -143, -145, -138, -181a, -200c, -203, -205, -206, -218, -363, -489, -491, and -596 [39]. …”

Section: Role Of Mirna In Oropharynx Tumorsmentioning

confidence: 99%

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Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies

et al. 2015

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Tobacco use and alcohol consumption are the main risk factors associated with head and neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic effects on the exposed epithelia of the upper aerodigestive tract. Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs), both encoding viral oncoproteins able to interfere with cell cycle control, have been recognized as the etiological agents of nasopharynx carcinoma and a fraction of oropharyngeal carcinoma, respectively. Head and neck SCC is a deadly disease and despite innovative treatments represents a major challenge for patients. Recently, a number of genomic studies have highlighted the molecular heterogeneity of head and neck SCC based on methylation profiles, microRNA expression, mutated genes and new druggable pathways which may represent new targets for cancer-tailored therapies. To date, cetuximab is the only FDA-approved anti-epidermal growth factor receptor therapy for the treatment of head and neck SCC. In addition, a number of monoclonal antibodies targeting AKT, mTOR and PI3K pathways are under evaluation. Several therapeutic vaccines against HPV16 and EBV proteins are also under study. The purpose of this article is to review the epidemiology, pathogenesis and molecular features of head and neck SCC, with an emphasis on new therapies.

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Section: Role Of Mirna In Oropharynx Tumorsmentioning

confidence: 99%

Section: Role Of Mirna In Oropharynx Tumorsmentioning

confidence: 99%

Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies

et al. 2015

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“…Появляются доказа-тельства того, что дисрегуляция микроРНК вследствие генетических мутаций, эпигенетических изменений, модификаций в биогегенезе, экспрессии поврежден-ного транскрипционного фактора или изменений в таргетных сайтах может приводить к прогрессии опухоли. В нескольких исследованиях установлены микроРНК при ПРГШ, которые представлены онко-генными транскриптами и супрессорами опухолевого роста [37]. К примеру, miR-130b гиперактивна при ПРГШ, что играет роль в эпителиально-мезенхималь-ном переходе [38,39].…”

Section: внутриопухолевая гетерогенностьunclassified

Treatment of Head and Neck Squamous Cell Carcinoma According on the Specific Molecular Features of the Tumor (A Literature Review)

Stukan¹,

Murashko²,

Бодня³

et al. 2017

Opuholi golovy šei

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“…Several miRNAs have been found to be up or downregulated in OSCC [52]. A molecular classification of OSCC based on 61 miRNAs with an accuracy of 93% was achieved [53].…”

Section: Introductionmentioning

confidence: 99%

Early detection and personalized treatment in oral cancer: the impact of omics approaches

Ribeiro

Barroso²,

Marques

et al. 2016

Mol Cytogenet

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BackgroundOral cancer is one of the most common malignant lesions of the head and neck. This cancer is an aggressive and lethal disease with no significant improvements in the overall survival in the last decades. Moreover, the incidence of oral HPV-positive tumors is rising, especially in young people. This oral neoplasm develops through numerous molecular imbalances that affect key genes and signaling pathways; however, the molecular mechanisms involved in the pathogenesis and progression of oral tumors are still to be fully determined. In order to improve the quality of life and long-term survival rate of these patients, it is vital to establish accurate biomarkers that help in the early diagnosis, prognosis and development of target treatments. Such biomarkers may possibly allow for selection of patients that will benefit from each therapy modality, helping in the optimization of intensity and sequence of the treatments in order to decrease side effects and improve survival.ConclusionIn this review we discuss the current knowledge of oral cancer and the potential role of omics approaches to identify molecular biomarkers in the improvement of early diagnosis, treatment and prognosis. The pursuit to improve the quality of life and decrease mortality rates of the oral patients needs to be centralized on the identification of critical genes in oral carcinogenesis. Understanding the molecular biology of oral cancer is vital for search new therapies, being the molecular-targeted therapies the most promising treatment for these patients.

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MicroRNAs and head and neck cancer: Reviewing the first decade of research

Cited by 71 publications

References 162 publications

Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies

Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies

Treatment of Head and Neck Squamous Cell Carcinoma According on the Specific Molecular Features of the Tumor (A Literature Review)

Early detection and personalized treatment in oral cancer: the impact of omics approaches

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