Micrornas Analysis in Patients with Myelodysplastic Syndrome. Possible Implications in Risk Stratification

Kontandreopoulou, Christina‐Nefeli; Syriopoulou, Stavroula; Diamantopoulos, Panagiotis; Giannakopoulou, Nefeli; Vlachopoulou, Dimitra; Katsiampoura, Panagiota; Stafylidis, Christos; Dimou, Maria; Galanopoulos, Athanasios; Papageorgiou, Sotirios; Hatzimichael, Eleftheria; Pappa, Vassiliki; Kotsianidis, Ιoannis; Symeonidis, Argiris; Panayiotidis, Panayiotis; Viniou, Nora‐Athina

doi:10.1182/blood-2022-165870

Cited by 2 publications

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“…Furthermore, low levels of miR-194-5p and miR-661 expression have been associated with decreased OS in MDS patients [54,61]. In a cohort of 41 patients, miR-125b-5p, miR-155-5p, and miR-181a-2-3p bone marrow transcript levels were found elevated in higher-risk patients [72] and, likewise, low expression levels of miR-21, miR-126, and miR-146b-5p have been detected in lower-risk compared to higher-risk MDS patients. Among them, elevated levels of miR-126 and miR-155 were associated with shorter OS and leukemia-free survival (LFS), while elevated levels of miR-124a tended to be associated with reduced survival rates [73].…”

Section: Mirnas As Potential Prognostic Biomarkers In Mdsmentioning

confidence: 96%

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Cancers

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Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

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Section: Mirnas As Potential Prognostic Biomarkers In Mdsmentioning

confidence: 96%

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Cancers

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The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Preprint

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Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia and an increased risk for evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review will present a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

show abstract

Micrornas Analysis in Patients with Myelodysplastic Syndrome. Possible Implications in Risk Stratification

Cited by 2 publications

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The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

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