Abstract:The reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a clinical challenge as chronic local inflammation can largely impair bone healing. Here, we used magnesium silicate nanospheres (MSN) to load a nucleic acid drug - microRNA146a-5p (miR146a), fabricating a nanobiomaterial complex MSN-miR146a with high oligo transfection efficiency. This complex showed a potent promoting effect on osteogenic differentiation of human dental pulp stem cells with upregulat… Show more
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