MicroRNA variants in endometriosis and its severity

Farsimadan, Marziye; Haje, Milat Ismail; Mawlood, C Khudhur; Arabipour, I; Emamvirdizadeh, Alireza; Takamoli, S; Masumi, Minowa; Vaziri, Hamidreza

doi:10.1080/09674845.2021.1889157

Cited by 16 publications

(14 citation statements)

References 25 publications

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“…Recent studies showed that the levels of miRNAs 199b-3p, 224-5p, and Let-7d-3p in plasma are potential diagnostic biomarkers for endometriosis patients [ 165 ]. In addition, miR-146a, miR-149 and miR-499 may have a role in the pathogenesis of endometriosis [ 166 ].…”

Section: Biomarkersmentioning

confidence: 99%

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

Smolarz

Szyłło

Romanowicz

2021

IJMS

217

112

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Endometriosis is a “mysterious” disease and its exact cause has not yet been established. Among the etiological factors, congenital, environmental, epigenetic, autoimmune and allergic factors are listed. It is believed that the primary mechanism of the formation of endometriosis foci is retrograde menstruation, i.e., the passage of menstrual blood through the fallopian tubes into the peritoneal cavity and implantation of exfoliated endometrial cells. However, since this mechanism is also observed in healthy women, other factors must also be involved in the formation of endometriosis foci. Endometriosis is in many women the cause of infertility, chronic pain and the deterioration of the quality of life. It also represents a significant financial burden on health systems. The article presents a review of the literature on endometriosis—a disease affecting women throughout the world.

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Section: Biomarkersmentioning

confidence: 99%

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

Smolarz

Szyłło

Romanowicz

2021

IJMS

217

112

View full text Add to dashboard Cite

show abstract

“…Not being able to ovulate has been considered the major cause of infertility among women that can be a result of different factors including, social, genetic, endocrine, physiological and phycological factors as well as lifestyle habits (ie smoking and alcohol consumption) 4 . However, approximately 15%–30% of cases of female infertility still remain unexplained 5,6 . Different studies have shown the significant role of microbiomes in human reproduction 7,8 .…”

Section: Introductionmentioning

confidence: 99%

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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Background Hepatitis B virus (HBV) has been considered a significant cause of human reproductive failure in different studies; however, there is a considerable disagreement on the true impacts of HBV on female reproduction. This study has evaluated the impact of HBV infection on pregnancy complications in natural pregnancy and also on pregnancy outcomes in women undergoing in vitro fertilization (IVF) treatment. Method We searched Embase, Web of Science, PubMed and Google Scholar databases to identify the potentially relevant studies. Summary odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing, sensitivity analysis and publication bias testing were also performed. Results A total of 42 studies concerning the effect of HBV infection on the natural and IVF pregnancy were included in this study. Our meta‐analysis results revealed that HBV infection had a positive correlation to gestational diabetes mellitus (GDM) [OR = 1.32 (1.17–1.48) (p < 0.01)] and preterm birth [OR = 1.26 (1.14–1.40) (p < 0.01)] in natural pregnancy; however, HBV infection was not significantly associated with decreased fertility rates among the patients who underwent IVF. Conclusion This study revealed a strong association of GDM and preterm birth with higher rates of HBV infection in pregnant women. Also, our results suggested that HBV infection in patients undergoing IVF may not negatively influence the pregnancy outcome. It may be rational to conclude that IVF might be rather a safe and effective method for HBV+ females who desire to have children.

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“…We report significant associations of rs895819 and rs6505162 SNPs with higher rates of endometriosis, but no link with rs531564. The significance of miRNAs and their variants in different diseases have been indicated frequently ( 16 , 17 ), whereas several studies have specifically investigated the effects of miRNAs variants in female reproductive disorders, a few studies have been focused to determine the role of miRNAs variants in endometriosis ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

et al. 2022

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Background: While different studies have investigated the association of SNPs with female reproductive disorders, a limited number of studies have investigated the effect of microRNAs variants in endometriosis. In this study, we evaluated the prevalence and the association of three different miRNAs variants including, miR-27a rs895819, miR-124-1 rs531564, and miR-423 rs6505162 with endometriosis to help further elucidate the importance of these variants in female reproductive disorders.Methods: A total number of 440 women (220 cases and 220 controls) were included. DNA was extracted and genotyping of the SNPs was carried out by PCR.Results: The results showed that rs895819 and rs6505162 had a significant association with endometriosis under the dominant, recessive, co-dominant, and allelic model, but rs531564 was not linked to endometriosis. Our results also imply a protective effect on endometriosis severity for AG genotype and G allele in rs895819 (p < 0.001), and also for AA and AC genotypes in rs6505162 with severity in endometriosis (p < 0.001). Moreover, Hardy–Weinberg equilibrium, haplotype frequency, and linkage disequilibrium between SNPs were performed.Conclusion: miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are linked to endometriosis.

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MicroRNA variants in endometriosis and its severity

Cited by 16 publications

References 25 publications

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

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