MicroRNA transcriptome profiles during swine skeletal muscle development

McDaneld, T. G.; Smith, Timothy P. L.; Doumit, M. E.; Miles, Jeremy R.; Coutinho, Luiz Lehmann; Sonstegard, Tad S.; Matukumalli, Lakshmi K.; Nonneman, Dan; Wiedmann, Ralph T.

doi:10.1186/1471-2164-10-77

Cited by 101 publications

(88 citation statements)

References 60 publications

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“…Studies indicated that a large number of miRNAs were generally coexpressed with their host genes (Drummond et al, 2011), and expression of miRNAs had tissue specificity . McDaneld et al (2009) isolated miRNAs from pig skeletal muscle tissues and found that miR-206 had a high expression in skeletal muscle. Many miRNA expression profiles have been reported in sheep, cow, chicken, and other domestic animals (Huang et al, 2010;Li et al, 2010;Wang et al, 2012), but there is limited information about goat muscle miRNAs.…”

Section: Expression Profiling Of Muscle Mirnasmentioning

confidence: 99%

Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology

Ling

Ding²,

Zhang³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. MicroRNAs (miRNAs) are an important class of small noncoding RNAs that are highly conserved in plants and animals. Many miRNAs are known to mediate a myriad of cell processes, including proliferation and differentiation, via the regulation of some transcription and signaling factors, which are closely related to muscle development and disease. In this study, small RNA cDNA libraries of Boer goats were constructed. In addition, we obtained the goat muscle miRNAs by using Solexa deep-sequencing technology and analyzed these miRNA characteristics by combining it with the bioinformatics technology. Based on Solexa sequencing and bioinformatics analysis, 562 speciesconserved and 5 goat genome-specific miRNAs were identified, 322 of which exceeded 100 in the expression levels. The results of realtime quantitative polymerase chain reaction from 8 randomly selected miRNAs showed that the 8 miRNAs were expressed in goat muscle, and the expression patterns were consistent with the Solexa sequencing results. The identification and characterization of miRNAs in goat muscle provide important information on the role of miRNA regulation in muscle growth and development. These data will help to facilitate studies on the regulatory roles played by miRNAs during goat growth and development.

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Section: Expression Profiling Of Muscle Mirnasmentioning

confidence: 99%

Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology

Ling

Ding²,

Zhang³

et al. 2013

Genet. Mol. Res.

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show abstract

“…miR-1 and miR-206 have been identified playing important roles in human and mouse muscle development (Chen et al 2006;Kim et al 2006;Chen et al 2010;Dey et al 2011;Koutsoulidou et al 2011). In farm animals, miR-1 and miR-206 were found highly expressed in porcine and Chinese Qinchuan cattle skeletal muscle (McDaneld et al 2009;Sun et al 2013), and miR-206 was the most rich miRNA in chicken skeletal muscle (Li et al 2011). More interestingly, previous study revealed that a mutation in the 3′ UTR of myostatin (GDF8) gene creating an illegitimate target site for miR-1 and miR-206, and the translational inhibition of the myostatin gene contributes to the muscular hypertrophy of Texel sheep (Clop et al 2006).…”

Section: Discussionmentioning

confidence: 99%

The role of microRNA-1 and microRNA-206 in the proliferation and differentiation of bovine skeletal muscle satellite cells

Dai

Wang

Zhang

et al. 2015

In Vitro Cell.Dev.Biol.-Animal

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MicroRNAs (miRNAs) have been found to play essential roles in muscle cell proliferation and differentiation. MicroRNA-1 (miR-1) and microRNA-206 (miR-206), which are similar and have the same seed sequence, have specific roles in modulating skeletal muscle proliferation and differentiation in vitro and in vivo. However, there is no information about their function during bovine skeletal muscle satellite cell development. In this study, the profiles of miR-1 and miR-206 and their biological functions in bovine skeletal muscle cell development was investigated. The target genes were predicted, and we used a dual-luciferase reporter assay to demonstrate that miR-1 and miR-206 directly targeted the 3' untranslated region (3'UTR) of paired-box transcription factor Pax7 and histone deacetylase 4 (HDAC4). We showed that miR-1 and miR-206 facilitate bovine skeletal muscle satellite cell myogenic differentiation by restricting the expression of their target gene and that inhibition of miR-1 and miR-206 increased the Pax7 and HDAC4 protein levels and substantially enhanced satellite cell proliferation. Therefore, our results revealed the mechanism in which miR-1 and miR-206 positively regulate bovine skeletal muscle satellite cell myogenic differentiation via Pax7 and HDAC4 downregulation.

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“…The basic technologies for genome-wide expression analyses at the mRNA and protein levels have proven to be promising and powerful approaches in characterizing the changes in skeletal muscle biological processes [16][17][18]. In recent years, many transcriptome-or proteome-based studies have been successfully adopted for the analysis of the porcine skeletal muscle [7,[19][20][21][22][23][24][25]. But combining proteomic and transcriptional analyses of skeletal muscle is very limited and has been performed in human and mice [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Differential proteome and transcriptome analysis of porcine skeletal muscle during development

Qian

Feng

et al. 2012

Journal of Proteomics

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MicroRNA transcriptome profiles during swine skeletal muscle development

Cited by 101 publications

References 60 publications

Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology

Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology

The role of microRNA-1 and microRNA-206 in the proliferation and differentiation of bovine skeletal muscle satellite cells

Differential proteome and transcriptome analysis of porcine skeletal muscle during development

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