MicroRNA targeting by quercetin in cancer treatment and chemoprotection

Kim, Doo Hwan; Khan, Haroon; Ullah, Hammad; Hassan, Sherif T. S.; Šmejkal, Karel; Efferth, Thomas; Mahomoodally, Mohamad Fawzi; Xu, Suowen; Habtemariam, Solomon; Filosa, Rosanna; Lagoa, Ricardo; Rengasamy, Kannan R.R.

doi:10.1016/j.phrs.2019.104346

Cited by 75 publications

(44 citation statements)

References 212 publications

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“…Plant families rich in quercetin are Compositae, Passiflorae, Rhamnaceae, and Solanaceae [49]. Onions, asparagus, red leaf lettuce, apples, capers, and berries contain relatively high concentrations of quercetin [29,50].The botanical sources of quercetin have been summarized in Table 1. Biomolecules 2020, 10, 59 5 of 20…”

Section: Sourcesmentioning

confidence: 99%

“…The dietary intake of total flavonoids is estimated to be 200-350 mg/day, and the intake of quercetin is 10-16 mg/day. The recommended dosage of quercetin aglycone as a dietary supplement is 1 g/day [29][30][31]. It exhibits numerous beneficial effects on human health, acting as anti-carcinogenic, anti-inflammatory, anti-infective, and psychostimulant agent.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

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Section: Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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“…Among included articles, several of them determined effects of the flavonoid in different specific mechanisms [27][28][29]34,38]. These include inhibition of chymotrypsin-like activity of the proteasome, involved in proteasomal regulation of cancer signaling pathways [27,38]; rise of intracellular labile zinc, which has second messenger molecule activities in tumor cells [34]; and modulation of microRNAs expression, highly involved in cancer development and chemoresistance [63], leading to inhibition of the oncogenic RNA-binding proteins insulin-like growth factor-2 binding protein 1 and 3 (IGF2BP1 and IGF2BP3) through the upregulation of miR-1275 [29]. Another study published in 2018 employed quercetin to analyze adequacy of the cellular antioxidant (CAA) assay in HepG2 cells in order to determine the antioxidant activity of extracts from tree nuts [28].…”

Section: Antitumor Properties Of Quercetin As Single Agent Against Hccmentioning

confidence: 99%

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

et al. 2019

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Quercetin is a flavonoid present in fruits, vegetables and plants with antioxidant, anti-inflammatory and anticancer properties. Its beneficial activities have been demonstrated in different human pathologies, including hepatoprotective effects against liver disorders. High mortality and late diagnosis of the primary liver tumor hepatocarcinoma (HCC) makes this cancer an interesting target for the study of quercetin effects. Our aim was to systematically review antitumor activities of quercetin in HCC preclinical studies employing single, encapsulated, combined or derived quercetin forms. Literature search was conducted in PubMed, Scopus and Web of Science (WOS), and 39 studies were finally included. We found that 17 articles evaluated quercetin effects alone, six used encapsulated strategy, 10 combined this flavonoid, two decided to co-encapsulate it and only four studied effects of quercetin derivatives, highlighting that only nine included in vivo models. Results evidence the quercetin antiproliferative and proapoptotic properties against HCC either alone and with the mentioned strategies; nevertheless, few investigations assessed specific activities on different processes related with cancer progression. Overall, further studies including animal models are needed to deeper investigate the precise mechanisms of action of quercetin as antitumor agent, as well as the potential of novel strategies aimed to improve quercetin effects in HCC.

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“…Many studies also demonstrated that Q can exert anti-cancer effect by regulating epigenetic modifications including, miRNA expression and DNA methylation, and enhance the sensitivity of tumor cells to chemotherapy. 76,77 Other studies also reported the antiinflammatory properties of Q nanoparticles and demonstrate that biodegradable Q nanoparticles increases the cellular uptake of chemotherapy drugs into cancer cells and enhances their cytotoxicity and antitumor properties. 78 Global DNA hypomethylation is a common epigenetic change in HCC and plays an important role in elevating chromosomal instability, and initiation and progression of HCC.…”

Section: Dovepressmentioning

confidence: 99%

<p>Biocompatibility, Cytotoxicity, Antimicrobial and Epigenetic Effects of Novel Chitosan-Based Quercetin Nanohydrogel in Human Cancer Cells</p>

Abbaszadeh¹,

Rashidipour²,

Khosravi³

et al. 2020

IJN

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Background: Previous studies have reported that quercetin (Q) has a potential antibacterial and anticancer activity. However, its application is limited by many important factors including high hydrophobicity and low absorption. Methodology: In the current study, we synthesized and characterized (Patent) a novel chitosan-based quercetin nanohydrogel (ChiNH/Q). Encapsulation efficiency was confirmed by UV/VIS spectrophotometer. Physicochemical characterization of ChiNH/Q was assessed by PDI, DLS, SEM, FTIR, and XRD. The toxicity of the ChiNH/Q against five strains of the pathogen and HepG2 cells was examined. Moreover, the quantification of ChiNH/Q on genomic global DNA methylation and expression of DNMTs (DNMT1/3A/3B) in HepG2 cancer cells were evaluated by ELISA and real-time PCR, respectively. Results: Under the SEM-based images, the hydrodynamic size of the ChiNH/Q was 743.6 nm. The changes in the PDI were 0.507, and zeta potential was obtained as 12.1 mV for ChiNH/Q. The FTIR peak of ChiNH/Q showed the peak at 627 cm −1 corresponded to tensile vibrational of NH 2-groups related to Q, and it is the indication of Q loading in the formulation. Moreover, XRD data have detected the encapsulation of ChiNH/Q. The ChiNH/Q showed a potent antimicrobial inhibitory effect and exerted cytotoxic effects against HepG2 cancer cells with IC 50 values of 100 µg/mL. Moreover, our data have shown that ChiNH/Q effectively reduced (65%) the average expression level of all the three DNMTs (p<0.05) and significantly increased (1.01%) the 5-methylated cytosine (5-mC) levels in HepG2 cells. Conclusion: Our results showed for the first time the bioavailability and potentiality of ChiNH/Q as a potent antimicrobial and anticancer agent against cancer cells. Our result provided evidence that ChiNH/Q could effectively reduce cellular DNMT expression levels and increase genomic global DNA methylation in HepG2 cancer cells. Our results suggest a potential clinical application of nanoparticles as antimicrobial and anticancer agents in combination cancer therapy.

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MicroRNA targeting by quercetin in cancer treatment and chemoprotection

Cited by 75 publications

References 212 publications

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

<p>Biocompatibility, Cytotoxicity, Antimicrobial and Epigenetic Effects of Novel Chitosan-Based Quercetin Nanohydrogel in Human Cancer Cells</p>

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