MicroRNA Regulation of Endocrine Functions in the Ovary

Brachova, Pavla; Hung, Wei‐Ting; McGinnis, Lynda K.; Christenson, Lane K.

doi:10.1007/978-3-319-25124-0_6

Cited by 4 publications

(4 citation statements)

References 94 publications

(136 reference statements)

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“…Ovarian functions such as folliculogenesis, oocyte maturation, ovulation, and luteal function are controlled by microRNA (miRNA) signalling [12]. Aberrant expression of miRNAs can alter endocrine functions.…”

Section: Hormonal Modulation and Endocrine Systemmentioning

confidence: 99%

“…The third type of epigenetic endocrine disruption is the aberrant expression of microRNAs (miRNAs). miRNAs are closely related to small interfering RNAs (siRNAs) which are involved in DNA methylation and histone modifications [ 9 ], and they are composed of 21–24 single stranded nucleotides [ 12 ]. miRNAs are noncoding RNA produced from introns/exons that bind to target mRNAs in order to suppress protein translation and posttranscriptional gene expression.…”

Section: Introduction To Epigeneticsmentioning

confidence: 99%

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Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System

Plunk

Richards

2020

International Journal of Endocrinology

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The epigenome of an individual can be altered by endogenous hormones, environment, age, diet, and exposure to endocrine disrupting chemicals (EDCs), and the effects of these modifications can be seen across generations. Epigenetic modifications to the genome can alter the phenotype of the individual without altering the DNA sequence itself. Epigenetic modifications include DNA methylation, histone modification, and aberrant microRNA (miRNA) expression; they begin during germ cell development and embryogenesis and continue until death. Hormone modulation occurs during the ageing process due to epigenetic modifications. Maternal overnutrition or undernutrition can affect the epigenome of the fetus, and the effects can be seen throughout life. Furthermore, maternal care during the childhood of the offspring can lead to different phenotypes seen in adulthood. Diseases controlled by the endocrine system, such as obesity and diabetes, as well as infertility in females can be associated with epigenetic changes. Not only can these phenotypes be seen in F1, but also some chemical effects can be passed through the germline and have effects transgenerationally, and the phenotypes are seen in F3. The following literature review expands upon these topics and discusses the state of the science related to epigenetic effects of age, diet, and EDCs on the endocrine system.

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Section: Hormonal Modulation and Endocrine Systemmentioning

confidence: 99%

Section: Introduction To Epigeneticsmentioning

confidence: 99%

Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System

Plunk

Richards

2020

International Journal of Endocrinology

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“…Histone modification often occurs concomitantly with DNA methylation and results in short- and long-term alterations in transcription program; another endocrine epigenetic alteration is the aberrant expression of microRNAs (miRNAs). The miRNAs are closely related to small interfering RNAs (siRNAs) that are involved in DNA methylation and histone modifications [ 8 ]. A growing number of studies are investigating the effects of EDCs, particularly BPA, on the reproductive system have been conducted in recent decades [ 8 ], including using granulosa in animal models [ 9 , 10 ] and in humans [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The miRNAs are closely related to small interfering RNAs (siRNAs) that are involved in DNA methylation and histone modifications [ 8 ]. A growing number of studies are investigating the effects of EDCs, particularly BPA, on the reproductive system have been conducted in recent decades [ 8 ], including using granulosa in animal models [ 9 , 10 ] and in humans [ 11 ]. There is increasing evidence from previous studies [ 12 , 13 ] demonstrating the role of EDCs in the pathogenesis of some female reproductive disorders, including polycystic ovarian syndrome, premature ovarian failure, endometriosis, reproductive tract anomalies, uterine fibroids and ectopic gestation.…”

Section: Introductionmentioning

confidence: 99%

Bitter Taste Receptors and Endocrine Disruptors: Cellular and Molecular Insights from an In Vitro Model of Human Granulosa Cells

Luongo

Passaponti

Haxhiu

et al. 2022

IJMS

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Endocrine disrupting chemicals (EDCs) are compounds that interfere with the synthesis, transport and binding action of hormones responsible for reproduction and homeostasis. Some EDCs compounds are activators of Taste bitter Receptors, a subclass of taste receptors expressed in many extraoral locations, including sperm and follicular somatic cells. This makes TAS2Rs attractive molecules to study and investigate to shed light on the effect of EDCs on female reproduction and fertility. This study aims to assess the effect of selected EDCs [namely Biochanin A (BCA), caffeine, Daidzein, Genistein and Isoflavone] on hGL5, an immortalized cell line exhibiting characteristics coherent with primary follicular granulosa cells. After demonstrating that this model expresses all the TAS2Rs (TAS2R3, TAS2R4, TAS2R14, TAS2R19, TAS2R43) specifically expressed by the primary human granulosa cells, we demonstrated that BCA and caffeine significantly affect mitochondrial footprint and intracellular lipid content, indicating their contribution in steroidogenesis. Our results showed that bitter taste receptors may be involved in steroidogenesis, thus suggesting an appealing mechanism by which these compounds affect the female reproductive system.

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Deciphering the miRNA transcriptome of granulosa cells from dominant and subordinate follicles at first follicular wave in goat

Meng,

Zhao,

Song

et al. 2023

Animal Biotechnology

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MicroRNA Regulation of Endocrine Functions in the Ovary

Cited by 4 publications

References 94 publications

Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System

Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System

Bitter Taste Receptors and Endocrine Disruptors: Cellular and Molecular Insights from an In Vitro Model of Human Granulosa Cells

Deciphering the miRNA transcriptome of granulosa cells from dominant and subordinate follicles at first follicular wave in goat

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