MicroRNA regulation of B cell receptor signaling

Borbet, Timothy C.; Hines, Marcus J.; Koralov, Sergei B.

doi:10.1111/imr.13024

Cited by 14 publications

(8 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the term "inflamma-miRs" was coined to refer to these miRNAs (Quinn and O'neill, 2011). Further, additional studies have progressively linked miRNAs to the neuroinflammatory signaling, including NF-κB signaling (Amjad et al, 2019), TLR signaling pathway (Paschon et al, 2016), B cell receptor signaling (Borbet et al, 2021), and Jak/Stat signaling (Zhang M. et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials

Liang

Wang

2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common cause of senile dementia. Although AD research has made important breakthroughs, the pathogenesis of this disease remains unclear, and specific AD diagnostic biomarkers and therapeutic strategies are still lacking. Recent studies have demonstrated that neuroinflammation is involved in AD pathogenesis and is closely related to other health effects. MicroRNAs (miRNAs) are a class of endogenous short sequence non-coding RNAs that indirectly inhibit translation or directly degrade messenger RNA (mRNA) by specifically binding to its 3′ untranslated region (UTR). Several broadly expressed miRNAs including miR-21, miR-146a, and miR-155, have now been shown to regulate microglia/astrocytes activation. Other miRNAs, including miR-126 and miR-132, show a progressive link to the neuroinflammatory signaling. Therefore, further studies on these inflamma-miRNAs may shed light on the pathological mechanisms of AD. The differential expression of inflamma-miRNAs (such as miR-29a, miR-125b, and miR-126-5p) in the peripheral circulation may respond to AD progression, similar to inflammation, and therefore may become potential diagnostic biomarkers for AD. Moreover, inflamma-miRNAs could also be promising therapeutic targets for AD treatment. This review provides insights into the role of inflamma-miRNAs in AD, as well as an overview of general inflamma-miRNA biology, their implications in pathophysiology, and their potential roles as biomarkers and therapeutic targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials

Liang

Wang

2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Endocytosis pathway was the second most significant pathway, and Mycobacterium tuberculosis often invades cells through endocytosis, so this pathway is closely related to the invasion mechanism of Mycobacterium tuberculosis ( 30 ). B cell receptor signaling pathway, an important immune pathway, can regulate the survival, proliferation and differentiation of B lymphocytes ( 31 , 32 ). In addition, we also found that among the six key genes previously screened, TP53 and AKT1 genes were in the herpes simplex virus 1 infection pathway, genes ARF1 and PRKCZ were in the endocytosis pathway, and gene AKT1 was in the B cell receptor signaling pathway, indicating that these four genes all play important regulatory roles in the pathway.…”

Section: Discussionmentioning

confidence: 99%

Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network

Yang

Sheng

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

PurposeTuberculosis is common infectious diseases, characterized by infectivity, concealment and chronicity, and the early diagnosis is helpful to block the spread of tuberculosis and reduce the resistance of Mycobacterium tuberculosis to anti-tuberculosis drugs. At present, there are obvious limitations in the application of clinical detection methods used for the early diagnosis of tuberculosis. RNA sequencing (RNA-Seq) has become an economical and accurate gene sequencing method for quantifying transcripts and detecting unknown RNA species.MethodsA peripheral blood mRNA sequencing was used to screen the differentially expressed genes between healthy people and tuberculosis patients. A protein-protein interaction (PPI) network of differentially expressed genes was constructed through Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. The potential diagnostic targets of tuberculosis were screened by the calculation of degree, betweenness and closeness in Cytoscape 3.9.1 software. Finally, the functional pathways and the molecular mechanism of tuberculosis were clarified in combination of the prediction results of key gene miRNAs, and by Gene Ontology (GO) enrichment analysis and the Kyoto Encyclopedia Genes and Genomes (KEGG) pathway annotation analysis.Results556 Differential genes of tuberculosis were screened out by mRNA sequencing. Six key genes (AKT1, TP53, EGF, ARF1, CD274 and PRKCZ) were screened as the potential diagnostic targets for tuberculosis by analyzing the PPI regulatory network and using three algorithms. Three pathways related to the pathogenesis of tuberculosis were identified by KEGG pathway analysis, and two key miRNAs (has-miR-150-5p and has-miR-25-3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network.ConclusionSix key genes and two important miRNAs that could regulate them were screened out by mRNA sequencing. The 6 key genes and 2 important miRNAs may participate in the pathogenesis of infection and invasion of Mycobacterium tuberculosis through herpes simplex virus 1 infection, endocytosis and B cell receptor signaling pathways.

show abstract

“…miRNAs are small non-coding RNAs that play crucial roles in post-transcriptional gene regulation. 20,21 miR-378a-3p is a member of the miR-378 family that has been reported to have multiple functions in various biological processes. [22][23][24] Recent studies have indicated that miR-378a-3p is involved in the regulation of osteoblast differentiation and bone formation.…”

Section: Introductionmentioning

confidence: 99%

Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation

Wang,

Sheng,

Yao

2023

J Orthop Surg (Hong Kong)

View full text Add to dashboard Cite

Background Osteoporotic fractures (OFs) are a significant public health issue, which can lead to pain and impaired mobility. The underlying mechanisms of OFs remain unclear, but recent studies have suggested that the circRNA-miRNA-mRNA pathway may play a crucial role. Purpose This study aimed to investigate the potential involvement of the circHIPK3/miR-378a-3p/HDAC4 pathway in the pathogenesis of OFs. Methods We collected tissue and serum samples from 10 patients with OFs and 10 healthy controls. The expression levels of circHIPK3, miR-378a-3p, and HDAC4 were measured by qPCR and WB. Additionally, we quantified the serum levels of bone metabolism-related indicators (ALP, OC, TRAP, OCIF, ODF) using ELISA. Results Our results revealed significant upregulation of circHIPK3 and HDAC4 in both tissue and serum samples from OF patients compared with controls. Simultaneously, we detected a lower expression level of miR-378a-3p in OF tissues and serum than that in the control group. Furthermore, the serum levels of bone metabolism-related indicators ALP, TRAP, OCIF, and ODF were significantly higher in OF patients than in the control group. Interestingly, the serum level of OCIF was lower in OF patients than in the control group. Conclusion Our study provides important evidence for the involvement of the circHIPK3/miR-378a-3p/HDAC4 pathway in the pathogenesis of OFs. The upregulation of circHIPK3 and HDAC4 and downregulation of miR-378a-3p observed in OF patients suggests their potential regulatory effects on bone metabolism. Meanwhile, abnormal expression of serum bone metabolism-related indicators may contribute to the development of OFs by disrupting the balance of bone remodeling.

show abstract

MicroRNA regulation of B cell receptor signaling

Cited by 14 publications

References 146 publications

Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials

Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials

Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network

Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation

Contact Info

Product

Resources

About