MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity

Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne‐Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari

doi:10.1111/exd.14497

Cited by 13 publications

(9 citation statements)

References 78 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNAs play crucial roles in various cellular processes and have been implicated in psoriasis pathogenesis. [7][8][9][10]14 Skin tissue collection by punch-biopsy method is extremely painful and in- individuals can serve as disease detection and progression markers. Psoriasis is characterized by a complex interplay of different cell types including epidermal keratinocytes, dermal fibroblasts and infiltrating immune cells.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from various genetic susceptibility factors, the contribution of epigenetic regulations by DNA methylation and miRNA deregulation among others have also been reported in the literature. 1,[4][5][6][7][8][9][10] MiRNAs play a crucial role in regulating various biological processes including cell proliferation, differentiation and signal transduction. [11][12][13] Deregulations of miRNAs and their potential to be used as a biomarker for disease diagnosis and progression have been studied in many diseases including psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…Histopathological examination of the lesional plaques shows hyperproliferation and abnormal differentiation of epidermal keratinocytes, immune cell infiltration and blood vessel dilation in the dermis. Apart from various genetic susceptibility factors, the contribution of epigenetic regulations by DNA methylation and miRNA deregulation among others have also been reported in the literature 1,4–10 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis

Ganguly,

Laha,

Senapati

et al. 2023

Experimental Dermatology

View full text Add to dashboard Cite

Psoriasis vulgaris is a chronic, autoimmune skin disease involving a complex interplay of epidermal keratinocytes, dermal fibroblast and infiltrating immune cells. Differential expressions of miRNAs are observed in psoriasis and the deregulated miRNAs are sometimes associated with disease severity. This study aims to identify miRNAs altered in the serum of psoriasis patients that are associated with the Psoriasis Area and Severity Index (PASI). In order to assess miRNA levels in the serum of psoriasis patients, we selected 24 differentially expressed miRNAs in the psoriatic skin are possibly derived from the skin and immune cells, as well as five miRNAs that are enriched in other tissues. We identified 16 miRNAs that exhibited significantly (p < 0.05) altered levels in the serum of psoriasis patients compared to healthy individuals. Among these, 13 miRNAs showed similar expression pattern in the serum of psoriasis patients as also observed in the psoriatic skin tissues. Ten miRNAs showed an accuracy of greater than 75% in classifying the psoriasis patients from healthy individuals. Further analysis of differential miRNA levels between the low PASI group and the high PASI group identified three miRNAs (miR‐147b, miR‐3614‐5p, and miR‐125a‐5p) with significantly altered levels between the low severity and the high severity psoriasis patients. Our systematic investigation of skin and immune cell‐derived miRNAs in the serum of psoriasis patients revealed alteration in miRNA levels to be associated with disease severity, which may help in monitoring the disease progression and therapeutic response.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis

Ganguly,

Laha,

Senapati

et al. 2023

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…microRNAs (miRNAs) are small non-coding RNA molecules able to post-transcriptionally modulate gene expression, and to contribute to the development or regulation of several diseases, including skin inflammation 11 . Only few studies have aimed to describe miRNA expression profiles in the skin of AD patients 12 , 13 , while multiple studies have been performed for PV 14 – 16 . Moreover, to our knowledge, only the earliest study from 2007 compared miRNA profiles of AD and PV skin, and indicated both similarities and differences between these two diseases 17 .…”

Section: Introductionmentioning

confidence: 99%

miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar

Carreras‐Badosa

Maslovskaja

Vaher

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory skin diseases with heterogeneous molecular backgrounds. MicroRNAs (miRNAs) contribute to either development or regulation of many immune system related diseases. Only few miRNA profiling studies are available for AD and no comparisons between AD and PV skin miRNA profiles have been performed recently. We conducted a miRNA profiling analysis of skin, as well as serum, from adult AD and PV patients and control individuals. 130 miRNAs were differentially expressed in AD skin, of which 77 were common differentially expressed in AD and PV. No differentially expressed miRNAs were detected in serum. Pathway analyses revealed differentially expressed miRNAs to potentially target immune-system related pathways, including TNF-α, IL-2/STAT4 and IL-6/JAK/STAT3. Additional genetic analysis of published AD GWAS dataset detected association of several target genes of differentially expressed miRNAs in skin. Moreover, miR-28-5p, miR-31-5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. All validated miRNAs were reliable predictive markers for AD or PV. In conclusion, miRNA expression pattern in the skin of adult AD patients is highly similar to that of PV with multiple differentially expressed miRNAs potentially involved in the regulation of immune responses in AD and PV.

show abstract

“…From a clinical perspective, miRNAs have been intensively studied in various human diseases such as cancers, metabolic disorders, infectious diseases, and immunological disorders as biomarkers and therapeutic targets 20 . The pathologies modulated by miRNAs have been examined in dermatologic diseases such as psoriasis [21][22][23] , atopic dermatitis 24 , and allergic contact dermatitis 25,26 . However, little is known about the roles of miRNAs in SD.…”

mentioning

confidence: 99%

Differential microRNA profiles in elderly males with seborrheic dermatitis

Kim

Yun

Baek

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Seborrheic dermatitis (SD) is one of the most common skin diseases characterized by inflammatory symptoms and cell proliferation, which has increased incidence in patients older than 50 years. Although the roles of microRNAs (miRNAs) have been investigated in several diseases, miRNA profiles of patients with SD remain unknown. This study aimed to identify differentially expressed miRNAs (DEMs) in lesions of elderly male patients with SD. We used a microarray-based approach to identify DEMs in lesions compared to those in non-lesions of patients with SD. Furthermore, Gene Ontology and pathway enrichment analysis were performed using bioinformatics tools to elucidate the functional significance of the target mRNAs of DEMs in lesions of patients with SD. Expression levels of two miRNAs—hsa-miR-6831-5p and hsa-miR-7107-5p—were downregulated, whereas those of six miRNAs—hsa-miR-20a-5p, hsa-miR-191-5p, hsa-miR-127-3p, hsa-miR-106b-5p, hsa-miR-342-3p, and hsa-miR-6824-5p—were upregulated. Functions of the SD-related miRNAs were predicted to be significantly associated with typical dermatological pathogenesis, such as cell proliferation, cell cycle, apoptosis, and immune regulation. In summary, SD alters the miRNA profile, and target mRNAs of the DEMs are related to immune responses and cell proliferation, which are the two main processes in SD pathogenesis.

show abstract

MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 13 publications

References 78 publications

Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis

Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis

miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar

Differential microRNA profiles in elderly males with seborrheic dermatitis

Contact Info

Product

Resources

About