MicroRNA-mediated signaling and regulation of nutrient transport and utilization

Chien, Pei-Shan; Chiang, Chih-Bin; Wang, Zhengrui; Chiou, Tzyy‐Jen

doi:10.1016/j.pbi.2017.06.007

Cited by 50 publications

(33 citation statements)

References 60 publications

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“…They are essential regulators of gene expression in plant developmental processes and adaptation to biotic and abiotic stress (Navarro et al , ; Chen, ; Li et al , ; ; Shivaprasad et al , ; Campo et al , ; Jeong and Green, ; Baldrich et al , ; Baldrich and San Segundo, ; Song et al , ). Evidence also supports a regulation of nutrient homeostasis by certain miRNAs in plants (Liang et al , ; Paul et al , ; Chien et al , ). The best‐known examples of miRNAs involved in nutrient homeostasis are miR399 and miR827 (phosphate homeostasis), miR395 (sulphur homeostasis), and miR826 and miR5090 (nitrogen homeostasis).…”

Section: Introductionmentioning

confidence: 87%

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Phosphate excess increases susceptibility to pathogen infection in rice

Campos-Soriano

Bundó

Bach‐Pages

et al. 2020

Molecular Plant Pathology

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Phosphorus (P) is an essential nutrient for plant growth and productivity. Due to soil fixation, however, phosphorus availability in soil is rarely sufficient to sustain high crop yields. The overuse of fertilizers to circumvent the limited bioavailability of phosphate (Pi) has led to a scenario of excessive soil P in agricultural soils. Whereas adaptive responses to Pi deficiency have been deeply studied, less is known about how plants adapt to Pi excess and how Pi excess might affect disease resistance. We show that high Pi fertilization, and subsequent Pi accumulation, enhances susceptibility to infection by the fungal pathogen Magnaporthe oryzae in rice. This fungus is the causal agent of the blast disease, one of the most damaging diseases of cultivated rice worldwide. Equally, MIR399f overexpression causes an increase in Pi content in rice leaves, which results in enhanced susceptibility to M. oryzae. During pathogen infection, a weaker activation of defence‐related genes occurs in rice plants over‐accumulating Pi in leaves, which is in agreement with the phenotype of blast susceptibility observed in these plants. These data support that Pi, when in excess, compromises defence mechanisms in rice while demonstrating that miR399 functions as a negative regulator of rice immunity. The two signalling pathways, Pi signalling and defence signalling, must operate in a coordinated manner in controlling disease resistance. This information provides a basis to understand the molecular mechanisms involved in immunity in rice plants under high Pi fertilization, an aspect that should be considered in management of the rice blast disease.

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Section: Introductionmentioning

confidence: 87%

“…Evidence also supports a regulation of nutrient homeostasis by certain miRNAs in plants (Liang et al, 2015;Paul et al, 2015;Chien et al, 2017). The best-known examples of miRNAs involved in nutrient homeostasis are miR399 and miR827 (phosphate homeostasis), miR395 (sulphur homeostasis), and miR826 and miR5090 (nitrogen homeostasis).…”

Section: Introductionmentioning

confidence: 96%

Phosphate excess increases susceptibility to pathogen infection in rice

Campos-Soriano

Bundó

Bach‐Pages

et al. 2020

Molecular Plant Pathology

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“…As expounded in several reviews, miRNAs mediate important regulatory processes under metal stress 20,22,24,51 . MiR397, miR398, miR408, and miR857 are the well characterized Cu miRNAs 22 .…”

Section: Important Mirnas In Response To Cu Toxicity In Citrusmentioning

confidence: 99%

“…In addition to protein-coding RNAs, emerging evidence has revealed that ncRNAs also play essential regulatory roles in plant stress responses, including Cu stress [23]. MicroRNAs (miRNAs), one main class of ncRNA with a length of 19 to 24 nucleotides, participate in Cu homeostasis by repressing translation or directly degrading Cu-related proteins in plants [22,24]. Previous studies found that Cu deficiency induced the expression of miR397, miR408, and miR857, which repressed a number of Cucontaining proteins such as CSD1, CSD2, LAC, COX subunit 5b (COX5b-1), and Cu chaperone for SOD (CCS1) [20,25,26], while Cu excess downregulated miR398 to induce the expression of CSD1 and CSD2 [27].…”

Section: Introductionmentioning

confidence: 99%

Construction of a ceRNA regulatory network in Ziyang xiangcheng (Citrus junos Sieb. ex Tanaka) based on whole-genome transcriptome profiling of mRNAs, lncRNAs, miRNAs and circRNAs under Cu toxicity

Fu¹,

Zhang²,

Qiu³

et al. 2019

Preprint

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Background Copper (Cu) toxicity has become a potential threat for citrus production, but little is known about related mechanisms. This study aims to uncover the global molecular response of mRNAs, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) to Cu toxicity and to construct their competing endogenous RNAs (ceRNAs) network in citrus.Results In this study, tolerance of four commonly used rootstocks to Cu toxicity was first evaluated, and ‘Ziyang Xiangcheng’ (Citrus junos ) was proved to be tolerant rootstock. Then the Cu-treated and -untreated root (CuR, CKR) and leaf (CuL, CKL) of ‘Ziyang Xiangcheng’ was selected to perform whole-genome transcriptome sequencing. In total, 5734 and 222 mRNAs, 164 and 5 lncRNAs, 45 and 17 circRNAs, and 147 and 130 miRNAs were identified to be differentially expressed (DE) in CuR/CKR and CuL/CKL, respectively. Gene ontology enrichment analysis of these DEmRNAs and targets of DElncRNAs and DEmiRNAs showed that most were annotated to oxidation-reduction, phosphorylation, membrane, and ion binding. The ceRNA network was constructed with the predicted DEmRNAs-DEmiRNAs and DElncRNAs-DEmiRNAs pairs, which further revealed regulatory roles of these DERNAs in Cu toxicity.Conclusions A large number of mRNAs, lncRNAs, circRNAs, and miRNAs were altered in response to Cu toxicity in citrus, and they may play crucial roles in mitigation of Cu toxicity through the ceRNA regulatory network.

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“…The minor errors during development can lead to the lesion of the atrium, ventricle, valve and other heart structures, which results in the occurrence of CHD. microRNAs (miRNAs/miRs) are a type of non-coding single-stranded RNA of ~22 nucleotides in length, which have important regulatory functions within cells (5). In recent years, miRNAs have received increasing attention in the field of heart development (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease

Chen

et al. 2018

Int J Mol Med

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Our previous studies identified that the expression of microRNA-29c (miR-29c-3p) was significantly increased in the serum of pregnant women carrying fetuses with congenital heart disease (CHD) compared with in that of normal pregnant women. However, the mechanism by which miR-29c-3p affects development of the embryonic heart remained unclear. The aim of the present study was to investigate the effect and potential molecular mechanism of miR-29c-3p overexpression on P19 cell proliferation, apoptosis and differentiation. miR-29c-3p-overexpression and protein kinase Bγ (Akt3)-knockdown cell lines were constructed using transfection technology. The function of miR-29c-3p and Akt3 in cardiomyocyte development was investigated by determining the proliferation, apoptosis and differentiation of P19 cells, which can differentiate into cardiomyocytes induced by dimethylsulfoxide. Bioinformatic analysis and luciferase assays were performed to explore the association between Akt3 and miR-29c-3p. The results of the present study revealed that miR-29c-3p overexpression and Akt3 knockdown suppressed proliferation, and promoted apoptosis and differentiation in P19 cells. Akt3 was also demonstrated to be a target of miR-29c-3p. Therefore, overexpression of miR-29c-3p may inhibit proliferation, and promote apoptosis and differentiation in P19 cells by inhibiting the expression of Akt3. miR-29c-3p may be a potential therapeutic target for the treatment of CHD.

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MicroRNA-mediated signaling and regulation of nutrient transport and utilization

Cited by 50 publications

References 60 publications

Phosphate excess increases susceptibility to pathogen infection in rice

Phosphate excess increases susceptibility to pathogen infection in rice

Construction of a ceRNA regulatory network in Ziyang xiangcheng (Citrus junos Sieb. ex Tanaka) based on whole-genome transcriptome profiling of mRNAs, lncRNAs, miRNAs and circRNAs under Cu toxicity

Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease

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