Abstract:Introduction: Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder that is defined by the buildup
of amyloid beta peptide (Aβ) plaques in the brain. Herein, we aim to investigate two microRNA (miRNA), miR-106b and miR-153, for their ability to inhibit the synthesis of amyloid beta precursor protein. Since miR-106b and miR-153 are also deficient in AD patients, we hypothesize that increasing their concentrations in the brain will reduce plaque development, thereby ameliorating AD sympto… Show more
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