MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity

Ashrafizadeh, Milad; Zarrabi, Ali; Orouei, Sima; Hushmandi, Kiavash; Hakimi, Azadeh; Zabolian, Amirhossein; Daneshi, Salman; Samarghandian, Saeed; Baradaran, Behzad; Najafi, Masoud

doi:10.1016/j.ejphar.2020.173660

Cited by 54 publications

(27 citation statements)

References 248 publications

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“…Ma et al [ 71 ] found that ecotropic viral integration site-1 (EVI1) confers ovarian cancer cells with cisplatin resistance by inducing autophagy through targeting of the TOPK promoter region in ovarian cancer. In addition, microRNA-mediated autophagy regulation in cancer treatment also plays an important role in chemotherapy resistance/sensitivity [ 72 ]; for example, a previous report indicated that miR-216b enhanced chemosensitivity by regulating PBK [ 58 ]. These studies suggest that TOPK is a novel autophagy regulator and that targeting TOPK benefits the sensitivity of anticancer clinical drugs.…”

Section: Others Factors: Inflammation Dna Damage and Autophagymentioning

confidence: 99%

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

Huang

Lee

Liu

et al. 2021

Cancers

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T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1; thus, the direct or indirect interactions of TOPK make it a highly attractive yet elusive target for cancer therapy. Small molecule inhibitors targeting TOPK have shown great therapeutic potential in the treatment of cancer both in vitro and in vivo, even in combination with chemotherapy or radiotherapy. Therefore, targeting TOPK could be an important approach for cancer prevention and therapy. Thus, the purpose of the present review was to consider and analyze the role of TOPK as a drug target in cancer therapy and describe the recent findings related to its role in tumor development. Moreover, this review provides an overview of the current progress in the discovery and development of TOPK inhibitors, considering future clinical applications.

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Section: Others Factors: Inflammation Dna Damage and Autophagymentioning

confidence: 99%

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

Huang

Lee

Liu

et al. 2021

Cancers

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“…During this process, peptides and amino acids that are necessary for cells can be supplied. 112 Autophagy can be observed during the treatment of cancer for both normal and cancer cells. Autophagy may increase resistance to both chemotherapy and radiotherapy.…”

Section: Autophagymentioning

confidence: 99%

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Yang

Najafi

2021

Basic Clin Pharma Tox

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“…It is worth mentioning that Res enhances LC-3II, Beclin-1 and ATG7 expression levels in triggering autophagy in CSCs and reducing breast cancer progression [ 353 ]. It is worth mentioning that autophagy has both tumor-promoting and tumor-suppressor roles in cancer [ 221 , 354 , 355 ] and its induction by Res requires more clarification.…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

“…Therefore, autophagy induction by ginsenoside Rh2 is of importance for inhibiting β-catenin-mediated CSC features in skin cancer [ 405 ]. However, a special attention should be directed towards autophagy, as it has both tumor-promoting and tumor-suppressor roles in cancer [ 355 ]. An experiment demonstrates that ginsenoside F2 (0–120 μM) stimulates apoptosis and autophagy in breast CSCs.…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity

Cited by 54 publications

References 248 publications

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

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