MicroRNA let-7: A promising non-invasive biomarker for diagnosing and treating external genital endometriosis

Покровенко, Д. А.; Vozniuk, Volodymyr; Медведєв, М. В.

doi:10.4274/tjod.galenos.2021.07277

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Grechukhina et al discovered inherited polymorphism of a let-7 miRNA binding site in KRAS in patients with severe endometriosis [ 118 ]. The role of let-7 miRNA is currently under intensive research as a potential biomarker and therapeutic target in endometriosis and gynecological cancers as well [ 119 , 120 ].…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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“…Pokrovenko et al enrolled 64 endometriotic infertile patients with dysmenorrhea in stages I–IV of disease, and miRNA extraction revealed downregulation of miR-let-7 [ 94 ], although the relative expression in the Log2(ratio) between the patients and controls corresponded to 0.6 [ 94 ]. Regarding dysmenorrhea, in the Bendifallah et al study, 100% of the patients with stages I–IV of endometriosis were dysmenorrheic [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

Liquid Biopsy in Endometriosis: A Systematic Review

Ronsini

Fumiento

Iavarone

et al. 2023

IJMS

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Despite laparoscopy being a standardized option to diagnose pelvic endometriotic implants, non-invasive biomarkers are necessary to avoid the discomfort of invasive procedures. Recent evidence suggests a potential role of microRNAs (miRNAs) as feasible biomarkers for the early diagnosis of endometriosis. Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched PubMed, EMBASE, Scopus, Cochrane Library, and Science Direct in January 2023. We provided no restriction on the country and year of publication, and considered English published articles. We selected studies including patients with endometriosis and describing miRNA regulation in the context of endometriosis. Overall, 45 studies fulfilled the inclusion criteria, and 2045 patients with endometriosis and 1587 controls were screened. Patients were analyzed concerning miRNAs expression and sources, stage of disease, and symptoms, and compared to controls. Among DEMs, the ones with the widest delta between endometriosis patients and controls—Relative Expression ≥ 4 Log2(ratio)—were miR-145, miR-191, miR-195, miR-21-5p, miR-106b-5p, miR-195-5p, miR-451a, miR-200c, miR-20a-5p, and miR-15a-5p. Although the epigenetic regulation is partially unclear, miRNAs are valid biomarkers to diagnose endometriotic lesions in symptomatic and non-symptomatic women. MiRNAs modulation should be clarified, especially during therapies or relapse, to plan targeted management protocols.

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“…In comparison to CA-125, let-7 exhibited be er specificity for distinguishing patients with and without endometriosis. Let-7 emerged as a promising diagnostic marker, prompting the researchers to plan an endometriosis diagnostic and treatment algorithm [78].…”

Section: Management (Treatment and Prognosis)mentioning

confidence: 99%

<span data-contrast="auto">Evaluating the Prognostic Potential of CA-125 and miRNA Levels in Endometriosis: A Narrative Review <span data-ccp-props="{">

Shokrnejad-Namin,

Amini,

Amoozgar

et al. 2024

Preprint

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Objective: This study aims to examine CA-125 and miRNAs as biomarkers in endometriosis pathophysiology and their potential roles in clinical diagnostics and prognostics. Methods:We reviewed a variety of studies, including cross-sectional, case-control, and prospective designs, examining a broad spectrum of patient demographics, clinical features, and biomarker (CA-125 and miRNA) expression levels. Results: CA-125 has been reaffirmed as a valuable biomarker in diagnosing and monitoring endometriosis, with its utility enhanced when used alongside other markers. MiRNAs have emerged as promising molecular regulators, offering new avenues for non-invasive diagnostics and a deeper understanding of the disease's pathophysiology. The integration of these biomarkers presents a potential shift towards more personalized and effective diagnostic and therapeutic strategies. Conclusion: Endometriosis presents a significant challenge in women's health, requiring innovative approaches for its management. The convergence of CA-125 and miRNA research represents a promising advance, potentially leading to more accurate diagnostics and personalized treatment. Future research should focus on standardizing methodologies, expanding study cohorts, and integrating findings into clinical practice to fully harness the potential of these biomarkers.

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MicroRNA let-7: A promising non-invasive biomarker for diagnosing and treating external genital endometriosis

Cited by 5 publications

References 24 publications

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Liquid Biopsy in Endometriosis: A Systematic Review

<span data-contrast="auto">Evaluating the Prognostic Potential of CA-125 and miRNA Levels in Endometriosis: A Narrative Review <span data-ccp-props="{">

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