MicroRNA in aqueous humor from patients with cataract

Dunmire, Jeffrey; Lagouros, Evan; Bouhenni, Rachida; Jones, Marc F; Edward, Deepak P.

doi:10.1016/j.exer.2012.10.016

Cited by 75 publications

(76 citation statements)

References 30 publications

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“…These miRNAs maybe maintain the shape of the anterior chamber and the pressure of the aqueous humor by regulating the target genes of the organizations related to the anterior chamber, such as the trabecular meshwork. In addition, 20 kinds of miRNAs were compared in the aqueous humor, revealing that 17 kinds of miRNAs may exist only in the aqueous humor, which demonstrated the tissue specificity [20] . Additionally, some researchers collected aqueous humor through the anterior chamber paracentesis and evaluated the total RNA concentration (14-85 ng/mL) and length (<200 nt) in the aqueous humor for the first time [21] .…”

Section: The Relationship Between Mirna and The Aqueous Humormentioning

confidence: 99%

Relationship between the Pathogenesis of Glaucoma and miRNA

Guo

Shen

et al. 2017

Ophthalmic Res

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Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating biological processes of glaucoma-related genes. This article reviews the connection between the aqueous humor, trabecular meshwork, the apoptosis of retinal ganglion cells, and miRNA.

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Section: The Relationship Between Mirna and The Aqueous Humormentioning

confidence: 99%

Relationship between the Pathogenesis of Glaucoma and miRNA

Guo

Shen

et al. 2017

Ophthalmic Res

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“…Thus, microRNAs can exist outside cells, and be efficiently detected in the circulation (free, associated with proteins, or in membrane bound particles) [303], and in ocular tissues, including vitreous [304] and aqueous [305] fluids. Their value as biomarker is increased by the fact that they are resistant to degradation by endogenous nucleases and by repeated freeze-thawing.…”

Section: Epigeneticsmentioning

confidence: 99%

Biomarkers in Diabetic Retinopathy

et al. 2015

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■ AbstractThere is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which is not related to adiposity. Whilst improved diabetes care has substantially improved diabetes outcomes, the disease remains a common cause of working age adult-onset blindness. Diabetic retinopathy is the most frequently occurring complication of diabetes; it is greatly feared by many diabetes patients. There are multiple risk factors and markers for the onset and progression of diabetic retinopathy, yet residual risk remains. Screening for diabetic retinopathy is recommended to facilitate early detection and treatment. Common biomarkers of diabetic retinopathy and its risk in clinical practice today relate to the visualization of the retinal vasculature and measures of glycemia, lipids, blood pressure, body weight, smoking, and pregnancy status. Greater knowledge of novel biomarkers and mediators of diabetic retinopathy, such as those related to inflammation and angiogenesis, has contributed to the development of additional therapeutics, in particular for late-stage retinopathy, including intra-ocular corticosteroids and intravitreal vascular endothelial growth factor inhibitors ('anti-VEGFs') agents. Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics. Therefore, more effective treatments for diabetic retinopathy are necessary. New analytical techniques, in particular those related to molecular markers, are accelerating progress in diabetic retinopathy research. Given the increasing incidence and prevalence of diabetes, and the limited capacity of healthcare systems to screen and treat diabetic retinopathy, there is need to reliably identify and triage people with diabetes. Biomarkers may facilitate a better understanding of diabetic retinopathy, and contribute to the development of novel treatments and new clinical strategies to prevent vision loss in people with diabetes. This article reviews key aspects related to biomarker research, and focuses on some specific biomarkers relevant to diabetic retinopathy.

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“…Of the 110 miRs, miR-202, miR-193b, miR-135a, miR-365 and miR-376a were the most abundant. Many miRs have been identified so far in humans; only 264 were assayed, and 110 were detected out of those assayed [18]. miR-218, miR-195 and miR-452 were found in abundance in many body fluids, which includes aqueous humor, serum, urine, tears and saliva [19].…”

Section: Mirnas and Eye Disordersmentioning

confidence: 99%

Micro-RNAs and Their Roles in Eye Disorders

Raghunath¹,

Perumal²

2015

Ophthalmic Res

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Micro-RNAs (miRNAs) are members of the family of noncoding RNA molecules that regulate gene expression by translational repression and mRNA degradation. Initial identification of miRNAs revealed them only as developmental regulators; later, their radiated roles in various cellular processes have been established. They regulate several pathways, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation and proliferation. Their roles in eye disorders are being explored by biologists around the world. Eye physiology requires the perfect orchestration of all the regulatory networks; any defect in any of the networks leads to eye disorders. The dysregulation of miRNA expression has been reported in many eye disorders, which paves the way for new therapeutics. This review summarizes the biogenesis of miRNAs and their role in eye disorders. miRNA studies also have implications for the understanding of various complex metabolic pathways leading to disorders of the eye. The ultimate understanding leads to potential opportunities in evaluating miRNAs as molecular biomarkers, prognostic tools, diagnostic tools and therapeutic agents for eye disorders.

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MicroRNA in aqueous humor from patients with cataract

Cited by 75 publications

References 30 publications

Relationship between the Pathogenesis of Glaucoma and miRNA

Relationship between the Pathogenesis of Glaucoma and miRNA

Biomarkers in Diabetic Retinopathy

Micro-RNAs and Their Roles in Eye Disorders

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