MicroRNA: Important Player in the Pathobiology of Multiple Myeloma

Bi, Chonglei; Chng, Wee Joo

doi:10.1155/2014/521586

Cited by 42 publications

(36 citation statements)

References 134 publications

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“…Furthermore, miR-181a and -16 expression levels were associated with the labial SGPF score. miR-181a has been reported to be involved in hematological malignancies (24). For instance, miR-181a was Figure 1.…”

Section: Discussionmentioning

confidence: 99%

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Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Wang

Zhang

et al. 2017

Exp Ther Med

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Abstract. Sjögren syndrome (SS) is characterized by dysfunction of the exocrine glands, particularly the salivary and lacrimal glands. Thus, labial salivary gland biopsy is useful method for diagnosing SS. The aim of the present study was to investigate the microRNA (miRNA or miR) profile of labial salivary glands obtained from SS patients and to examine the correlation of miR-181a and -16 levels with the pathological grade in SS. miRNA expression in labial salivary gland tissues was profiled in 3 female patients with primary SS and 3 female patients with non-SS sicca syndrome using microarray analysis. In addition, a literature search and miRNA target gene prediction were performed to collect miRNAs involved in SS pathogenesis. Subsequent to integrating all database results, miR-181a and -16 were identified to be associated with the Ro/SS-associated antigen A and La/SS-associated antigen B during SS pathogenesis. Therefore, these miRNAs were selected for further verification in labial salivary gland tissues of 28 patients with SS and 18 non-SS sicca syndrome control individuals by quantitative reverse transcription-quantitative polymerase chain reaction. Compared with the control group, 76 miRNAs were upregulated and 51 were downregulated in the labial salivary gland of SS patients according to microarray results. In particular, miR-181a and -16 expression levels in the labial salivary gland of SS patients were decreased in comparison with those in the controls. Furthermore, the decreased expression levels of these miRNAs were associated with the labial salivary pathological focus scores. In conclusion, the present study examined the miRNA profiles in the labial salivary glands of SS patients and detected decreased miR-181a and -16 expression levels compared with the control individuals. Finally, the decreased levels of miR-181a and -16 were associated with the salivary gland pathological focus scores, suggesting that miR-181a and -16 may serve a role in the pathogenesis of SS.

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Section: Discussionmentioning

confidence: 99%

“…miR, microRNA; SS, Sjögren syndrome. overexpressed in T-/B-cell leukemia/lymphoma, while miR-181a-deficient mice demonstrated severe defects in T-cell development (24)(25)(26). This indicates that miR-181a may be involved in the pathogenesis of lymphocytic diseases.…”

Section: Discussionmentioning

confidence: 99%

Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Wang

Zhang

et al. 2017

Exp Ther Med

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“…28 Literature advocates the deregulation of several miRNAs including miR-15, 16, 17, 20, 135, 30, 150, 160 and so on, which are regarded as hallmarks of tumor progression, clinical staging, prognosis, and drug responses in MM. [29][30][31][32][33][34] Basic mechanisms of miRNAs include positive or negative regulation of critical oncogenes or tumor suppressors, epigenetic modifications etc. that predominantly determines cell survival and malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of MicroRNA-152 contributes to high expression of DKK1 in multiple myeloma

Chen

George

et al. 2015

RNA Biology

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Multiple myeloma (MM) induced bone lesion is one of the most crippling characteristics, and the MM secreted Dickkopf-1 (DKK1) has been reported to play important role in this pathologic process. However, the underlying regulation mechanisms involved in DKK1 expression are still unclear. In this study, we validated the expression patterns of microRNA (miR) 15a, 34a, 152, and 223 in MM cells and identified that miR-152 was significantly downregulated in the MM group compared with the non-MM group, and that miR-152 level was negatively correlated with the expression of DKK1 in the MM cells. Mechanistic studies showed that manipulating miR-152 artificially in MM cells led to changes in DKK-1 expression, and miR-152 blocked DKK1 transcriptional activity by binding to the 3 0 UTR of DKK1 mRNA. Importantly, we revealed that MM cells stably expressing miR-152 improved the chemotherapy sensitivity, and counteracted the bone disruption in an intrabone-MM mouse model. Our study contributes better understanding of the regulation mechanism of DKK-1 in MM, and opens up the potential for developing newer therapeutic strategies in the MM treatment.

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“…Accumulative evidence shows that epigenetic control of certain microRNA genes directly participates in the tumorigenesis process and correlates with unfavorable outcomes of cancer therapy [73,74]. A large number of miRNAs have been in the regulation of the autophagy process.…”

Section: Epigenetic Control Of Autophagy By Micrornasmentioning

confidence: 99%