2010
DOI: 10.4161/cbt.10.8.13083
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MicroRNAmiR-17-5pis overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion

Abstract: The microRNA-17-92 cluster is an oncogene in human B cell lymphomas and lung cancers. Previous microRNA microarray data revealed that miR-17-5p, a member of the miR-17-92 cluster, is upregulated in pancreatic cancer. However, the involvement of miR-17-5p expression in pancreatic carcinogenesis has not well been studied. In the present study, we measured the miR-17-5p expression levels in pancreatic cancer cell lines, primary cultures of normal human pancreatic ductal cells, formalin-fixed paraffin-embedded (FF… Show more

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Cited by 110 publications
(82 citation statements)
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References 40 publications
(50 reference statements)
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“…Therefore, we hypothesized that the status of miR-17-92 cluster expression could be an independent factor for predicting the prognosis of this disease. These results were consistent with previous studies in pancreatic cancer and oesophageal squamous cell carcinomas [31,32].…”
Section: Discussionsupporting
confidence: 83%
“…Therefore, we hypothesized that the status of miR-17-92 cluster expression could be an independent factor for predicting the prognosis of this disease. These results were consistent with previous studies in pancreatic cancer and oesophageal squamous cell carcinomas [31,32].…”
Section: Discussionsupporting
confidence: 83%
“…Expression profiling studies have revealed widespread overexpression of miR-17-5p in diverse tumor subtypes including both hematopoietic malignancies and solid tumors such as those derived from breast, colon and lung [15,16]. However, based on the previous studies it appears that miR-17-5p may have distinct effects in different kinds of tumors.…”
Section: Introductionmentioning
confidence: 94%
“…Whereas there appears to be an oncogenic role for this miRNA in some cancers including melanoma (Segura et al 2009), endometrioid endometrial cancer (Myatt et al 2010), and glioma ; in others, such as lung adenocarcinoma (Sun et al 2010;Zhang et al 2011) and human gastric adenocarcinoma (Kong et al 2012), its role is more akin to that of a tumor suppressor. Such dual-function miRNAs have been previously reported: miR-26a (Sander et al 2008;Huse et al 2009;Kota et al 2009;Kim et al 2010), miR-205 (Iorio et al 2007, 2009Gandellini et al 2009;Wu et al 2009), and miR-17-5p (Hossain et al 2006;Mraz et al 2009;Yu et al 2010;Li et al 2011) are all characterized examples. In the latter case, the molecular mechanism underlying the dual phenotype was uncovered through systematic screening of predicted targets through luciferase assays (Cloonan et al 2008).…”
Section: Kip1mentioning
confidence: 99%