MicroRNA Expression Profiles in Upper Tract Urothelial Carcinoma Differentiate Tumor Grade, Stage, and Survival: Implications for Clinical Decision-Making

Browne, Brendan; Stensland, Kristian; Patel, Chintan K.; Sullivan, Travis; Burks, Eric; Canes, David; Raman, Jay D.; Warrick, Joshua; Reiger-Christ, K.

doi:10.1016/j.urology.2018.10.004

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…For example, in a prognostic biomarker study, lower miR-31 and miR-149 in tumor tissue were reported to be independently associated with tumor progression and higher stage, and lower miR-149 expression was associated with lower cancer-specific survival [44]. When focusing on risk stratification of UTUC patients, four different sets of four miRNAs were associated with high-grade UTUC and predicted pT2 disease, recurrence-free survival, and overall survival [45]. In a study analyzing miRNAs present in the serum of UTUC patients, miR-151b discriminated between patients with high and low probabilities of tumor progression and cancer-specific survival [46].…”

Section: 3mentioning

confidence: 99%

Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

et al. 2020

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Section: 3mentioning

confidence: 99%

Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

et al. 2020

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“…Finally, using tissue samples from 157 patients that had undergone radical nephroureterectomy, Browne et al sought to determine if miRNA expression patterns could be used to stratify tumors by grade (high grade versus low grade) and whether the tumor invaded muscle [ 232 ]. They discovered that high-grade UTUC differentially expressed miR-29b-2-5p, miR-18a-5p, miR-223-3p and miR-199a-5p compared to low-grade UTUC [ 232 ]. Importantly, none of these were identified in the aforementioned studies.…”

Section: Promising Microrna Biomarkers In Utucmentioning

confidence: 99%

“…Importantly, none of these were identified in the aforementioned studies. They also observed miRNAs differentially expressed in muscle-invasive compared with non-muscle-invasive samples: miR-10b-5p, miR-26a-5p-5p, miR-31-5p and miR-146b-5p [ 232 ]. Of these, miRNA-31 was previously reported [ 225 ].…”

Section: Promising Microrna Biomarkers In Utucmentioning

confidence: 99%

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

Cinque

Capasso

Vago

et al. 2022

IJMS

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Upper urinary tract urothelial carcinoma (UTUC) represents a minor subgroup of malignancies arising in the urothelium of the renal pelvis or ureter. The estimated annual incidence is around 2 cases per 100,000 people, with a mean age at diagnosis of 73 years. UTUC is more frequently diagnosed in an invasive or metastatic stage. However, even though the incidence of UTUC is not high, UTUC tends to be aggressive and rapidly progressing with a poor prognosis in some patients. A significant challenge in UTUC is ensuring accurate and timely diagnosis, which is complicated by the non-specific nature of symptoms seen at the onset of disease. Moreover, there is a lack of biomarkers capable of identifying the early presence of the malignancy and guide-tailored medical treatment. However, the growing understanding of the molecular biology underlying UTUC has led to the discovery of promising new biomarkers. Among these biomarkers, there is a class of small non-coding RNA biomarkers known as microRNAs (miRNAs) that are particularly promising. In this review, we will analyze the main characteristics of UTUC and focus on microRNAs as possible novel tools that could enter clinical practice in order to optimize the current diagnostic and prognostic algorithm.

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“…2) (14). It has been shown that the expression levels of specific miRNAs differ on the type and stage of the tumor (24)(25)(26). The specific expression patterns of miRNAs determines the development of tumors.…”

Section: Mirnas In Mbmentioning

confidence: 99%

The mechanism of non‑coding RNAs in medulloblastoma (Review)

Zhao

Han

et al. 2021

Oncol Lett

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Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted in considerable progress in the treatment of this disease, the prognosis of patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve the therapeutic efficacy and reduce the side effects of MB, has become a research hotspot. In recent years, non-coding RNAs (ncRNAs), which were initially considered to be transcriptional noise, have been shown to possess regulatory functions. A series of ncRNAs have been identified, including microRNAs and circular RNAs, which affect the expression of specific genes in a variety of tumors. These genes lead to the formation of a specific complex of proteins or they directly participate in protein synthesis in order to regulate the occurrence and development of tumors. The aim of the present review article was to summarize the recent research studies that have explored the ability of ncRNAs to regulate the occurrence and development of MB. Contents 1. Introduction 2. miRNAs in MB 3. circRNAs in MB 4. Other ncRNAs in MB 5. Conclusions

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MicroRNA Expression Profiles in Upper Tract Urothelial Carcinoma Differentiate Tumor Grade, Stage, and Survival: Implications for Clinical Decision-Making

Cited by 11 publications

References 30 publications

Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

The mechanism of non‑coding RNAs in medulloblastoma (Review)

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