MicroRNA expression profile of cholesterol metabolism analysis mediated by <i>Thelenota ananas</i> desulfated holothurin A saponin in RAW264.7 macrophage-foam cells

Dou, Peipei; Tan, Yuqing; Li, Kaifeng; Hong, Hui; Zhu, Beiwei; Han, Qinghua

doi:10.1039/d2fo01373h

Cited by 2 publications

(2 citation statements)

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“…Furthermore, miR-365 was upregulated in extracellular vesicles isolated from cholesterol-loaded macrophages ( 29 ). In another study, multiple target genes related to the regulation of miR-365-2-5p were exhibited to be associated with functions related to cholesterol metabolism ( 30 ). These were all promotors to the development of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Association between miR-365 polymorphism and ischemic stroke in a Chinese population

Weng,

Yu,

Luo

et al. 2023

Front. Neurol.

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BackgroundIschemic stroke (IS) represents a major cause of morbidity and mortality across the globe. The aberrant expression of miR-365 has been found to be implicated in a wide array of human diseases, including atherosclerosis and cancer. Studies on single-nucleotide polymorphisms (SNPs) in miRNA genes can help gain insight into the susceptibility to the condition. This study aimed to examine the relationship between miR-365 SNPs and the risk of IS.MethodsThe study recruited 215 IS patients and 220 controls. The SNPscans genotyping was employed to genotype three polymorphic loci (rs121224, rs30230, and rs178553) of miR-365. The relative expression of miR-365 in peripheral blood mononuclear cells of the patients and controls was determined by using real-time quantitative PCR.ResultsThe miR-365 rs30230 polymorphism exhibited a significant association with the risk of developing IS (TC vs. CC: adjusted OR = 0.55, 95% CI: 0.33-0.92, P = 0.022; TT vs. CC: adjusted OR = 0.34, 95% CI: 0.14–0.85, P = 0.021; TC +TT vs. CC: adjusted OR = 0.51, 95% CI: 0.31–0.83, P = 0.007; T vs. C: adjusted OR = 0.57, 95% CI: 0.39–0.83, P = 0.004). Haplotype analysis revealed that the C-T-G haplotype was associated with a decreased risk of IS (OR = 0.68, 95% CI: 0.46–1.00, P = 0.047). Furthermore, miR-365 expression was significantly higher in IS patients than in controls (P < 0.001). Interestingly, patients with rs30230 TC or TT genotypes had lower miR-365 levels compared to their counterparts with CC genotypes (P < 0.001).ConclusionsThe miR-365 rs30230 polymorphism might bear an association with IS susceptibility in the Chinese population, and the rs30230 TC/TT genotype might be a protective factor against IS.

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Section: Discussionmentioning

confidence: 99%

Association between miR-365 polymorphism and ischemic stroke in a Chinese population

Weng,

Yu,

Luo

et al. 2023

Front. Neurol.

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“…Quinoa saponins is a byproduct of quinoa processing, which can also produce foam in an aqueous solution, and this foam is stable even at very low concentration (0.1%, taste tolerable). Therefore, quinoa saponins have potential application as a foaming agent (8)(9)(10)(11)(12)(13)(14). Takeshi et al developed alcohol-free beer with saponins, indicating that the addition of saponins made beer drinks foam richer and more delicate (15).…”

Section: Introductionmentioning

confidence: 99%

Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents

et al. 2023

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IntroductionWith the increasing importance attached to human health, the inclusion complex (IC) of phycocyanin (PC) into hydroxypropyl-β-cyclodextrin (HP-β-CD) have been devoted to developing the use of food preservation in this study.MethodsIn this experiment, the IC of PC into HP-β-CD was prepared by the freeze-drying method and characterized by OM, TEM, UV, FTIR and TG/DSC methods.Results and discussionThe spectroscopic features were evaluated by Ultraviolet-visible (UV-vis) spectroscopy and Fourier transform infrared spectroscopy (FT-IR) confirming that PC was located in the hydrophobic cavity of HP-β-CD. Consistent with the structural properties, optical microscopy (OM) and Transmission electron microscope (TEM) observed that the addition of PC subjected the IC to an aggregation state with irregular lamellar structures. Stability assessment showed that pH, heat and light tolerance of PC significantly regulated and improved due to the PC/HP-β-CD complexation. The formation of ICs was helpful to enhancing the antioxidant activity of PC. Molecular modeling suggested that the D-pyrrole ring and its associated C=C group of phycocyanin entered the HP-β-CD cavity from the wider edge. On this basis, the development of blue beer with quinoa saponins as foaming agent and ICs as colorant was explored. The addition of quinoa saponins made the foam richer and more delicate without destroying the overall taste coordination of beer. Moreover, the protective effect of HP-β-CD presents a positive impact on the stability of blue beer pigment. Hence, PC encapsulated into HP-β-CD will be an impressive approach in food-related application of PC.

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MicroRNA expression profile of cholesterol metabolism analysis mediated by Thelenota ananas desulfated holothurin A saponin in RAW264.7 macrophage-foam cells

Abstract: Saponins from the sea cucumber, Thelenota ananas, have been reported to modulate cholesterol metabolism and may be useful to treat atherosclerosis and related diseases, but the mechanism remains unclear. This...

Cited by 2 publications

References 50 publications

Association between miR-365 polymorphism and ischemic stroke in a Chinese population

Association between miR-365 polymorphism and ischemic stroke in a Chinese population

Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents

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