MicroRNA expression patterns of tumors in early-onset colorectal cancer patients

Ak, Seçil; Tunca, Berrin; Tezcan, Gülçin; Çeçener, Gülşah; Egelí, Ünal; Yılmazlar, Tuncay; Öztürk, Ersin; Yerci, Ömer

doi:10.1016/j.jss.2014.03.057

Cited by 31 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They can pair with the 3' untranslated region sites to regulate gene expression (Bartel, 2004). Many studies have identified aberrant miRNAs expression profiles in various cancers (Ak et al, 2014;Hu et al, 2014;Xia et al, 2014;Yang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Absolute quantification of lung cancer related microRNA by droplet digital PCR

Wang

et al. 2015

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Absolute quantification of lung cancer related microRNA by droplet digital PCR

Wang

et al. 2015

Biosensors and Bioelectronics

View full text Add to dashboard Cite

“…The expression of miR106a was found to be upregulated, and miR-143 and miR-125b levels were found to be downregulated in sporadic EOCRC tissues compared with the normal tissues. In addition, 2.42-fold high expression level of miR-106a and 2.42-fold low expression level of miR125b were observed in tumors with lymph node metastases compared with the normal colorectal mucosa samples [157] . On the other hand, epigenetic regulations of sporadic EOCRC tumors also differ between each other depend on MSI status.…”

Section: Sporadic Forms Of Eocrcmentioning

confidence: 89%

“…Molecular aspects of early-onset colorectal cancer ation is not observed in LS cases, thus, this discrepancy between sporadic MSI cancer and LS might be used in a strategy for the detection of LS [156] . The different attitude of sporadic and hereditary forms of EOCRC may also be caused by epigenetic modifications, such as miRNA expressions and their methylation patterns [47,157] . Balaguer et al [47] demonstrated that miR-622, miR-362-5p and miR-486-5p could accurately classify the LS and sporadic MSI cases.…”

Section: Sporadic Forms Of Eocrcmentioning

confidence: 99%

“…The similarity of miRNA expression status of LS and sporadic MSI cases may be explained with occurrence of frameshift mutations in TARBP2, a miRNA processing gene, in both of these diseases [158] . Moreover, in one of our study, using miRNA polymerase chain reaction arrays, the expression profiles of 38 different miRNAs associated with CRC were evaluated in 40 sporadic Turkish EOCRC patients [157] . The expression of miR106a was found to be upregulated, and miR-143 and miR-125b levels were found to be downregulated in sporadic EOCRC tissues compared with the normal tissues.…”

Section: Sporadic Forms Of Eocrcmentioning

confidence: 99%

See 1 more Smart Citation

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Tezcan

Tunca

et al. 2016

WJGO

Self Cite

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

show abstract

“…Notably, miR-143 has been suggested as a biomarker for various types of cancer (29,30). Qian et al (15) indicated that low levels of miR-143 in colorectal cancer tissues were closely associated with cancer stage and metastasis.…”

Section: Discussionmentioning

confidence: 99%