microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation

Mao, Aihong; Liu, Yang; Zhang, Hong; Chen, Di; Sun, Chao

doi:10.1089/dna.2014.2401

Cited by 32 publications

(30 citation statements)

References 138 publications

(96 reference statements)

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“…Ionising radiation changes the expression of at least 23 miRNAs many of which affect radiosensitivity, DNA repair and apoptosis, e.g. let-7, miR-21, miR-34s, miR-181a, and miR-449a (139). Radiation-induced transcription of some miRNAs (e.g.…”

Section: ‘Omics’ Approachesmentioning

confidence: 99%

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Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

et al. 2016

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Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to tumour cells. Since 80% of individual variation in clinical response is estimated to be caused by patient-related factors, identifying these factors might allow prediction of patients with increased risk of developing severe reactions. While inactivation of cell renewal is considered a major cause of toxicity in early-reacting normal tissues, complex interactions involving multiple cell types, cytokines, and hypoxia seem important for late reactions. Here, we review ‘omics’ approaches such as screening of genetic polymorphisms or gene expression analysis, and assess the potential of epigenetic factors, posttranslational modification, signal transduction, and metabolism. Furthermore, functional assays have suggested possible associations with clinical risk of adverse reaction. Pathway analysis incorporating different ‘omics’ approaches may be more efficient in identifying critical pathways than pathway analysis based on single ‘omics’ data sets. Integrating these pathways with functional assays may be powerful in identifying multiple subgroups of RT patients characterized by different mechanisms. Thus ‘omics’ and functional approaches may synergize if they are integrated into radiogenomics ‘systems biology’ to facilitate the goal of individualised radiotherapy.

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Section: ‘Omics’ Approachesmentioning

confidence: 99%

“…Radiation-induced transcription of some miRNAs (e.g. let-7a and let-7b) depends on ATM and p53 but ATM may also phosphorylate BRCA1 and KSRP which affects processing of pri-miRNA (139, 140). miRNAs such as miR-21 and miR-29a have been found to play important roles in renal fibrosis or systemic sclerosis (127, 141).…”

Section: ‘Omics’ Approachesmentioning

confidence: 99%

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

et al. 2016

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“…Recent studies have shown that in addition to these protein-coding genes, a subset of non-coding RNAs is also required for cellular responses to DNA damage [11,12]. To coordinate non-coding RNA-mediated DDR, DNA damage can alter the expression levels of non-coding RNAs [6,[13][14][15].…”

Section: Dna Damage Regulates the Biogenesis Of Noncoding Rnasmentioning

confidence: 99%

“…In the past decade, accumulating experimental evidence has shown that non-coding RNAs-including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), DNA damage response RNAs (DDRNAs), DSB-induced RNAs (diRNAs), small interfering RNA (siRNAs), and piwiinteracting RNAs (piRNAs)-are emerging new players in DDR [5]. DNA damage also induces alterations in the expression of these non-coding RNAs [6][7][8][9]. Based on the kinetics of DDR, noncoding RNA-associated molecular changes occur later than posttranslational protein modifications, such as phosphorylation, acetylation, and ubiquitination [10].…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNAs: An emerging player in DNA damage response

Zhang

Peng

2015

Mutation Research/Reviews in Mutation Research

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“…In this regard, a huge role belongs to miRNAs registered in blood or urine as radioresponse prediction markers. It was shown that cells after radiation reveal changes in miRNA expression [19]. Associations between changes in 20 miRNAs, their target genes, and biological effects are listed [20].…”

Section: Evaluation Of Mirna Expression and Target Genes As Biomarkermentioning

confidence: 99%

The miRNA as human cell gene activity regulator after ionizing radiation

et al. 2017

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Abstract⎯This review presents analysis of the literature and our own research with respect to the role of miRNAs in the regulation of activity (expression) of genes controlling cellular homeostasis in human cells when exposed to ionizing radiation. Human cells, on one hand, can have increased resistance to radiation, which hinders the effectiveness of tumor treatment in radiotherapy. On the other hand, increased sensitivity to radiation may be accompanied by the development of several pathologies, including tumorigenesis. This paper examines the role of specific miRNAs in the formation of radioresistance and radiosensitivity of human cells and their impact on the respective target genes. Separate sections are devoted to the role of different miRNAs in radiation therapy of tumors of different localization, as well as their role in the bystander effect. A special section highlights features of gene activity and its regulators, miRNAs, in radiosensitive cells in patients with Down syndrome. The final section provides information about new approaches to change miRNA expression and, accordingly, their target genes by the action of plant and synthetic drugs (crown compounds) which reduce damaging effects of mutagens. It is assumed that antimutagens affecting the expression levels of miRNAs and structural genes may be used to correct the increase and decrease in cellular radioresponse, reducing the risk of development of pathological processes, including tumorigenesis.

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microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation

Cited by 32 publications

References 138 publications

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

Non-coding RNAs: An emerging player in DNA damage response

The miRNA as human cell gene activity regulator after ionizing radiation

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