Abstract:Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNA known to play a role in human brain development and neurogenesis. Here, we perform small-RNA sequencing across 212 mid-gestation human neocortical tissue samples, profiled 907 miRNAs, discovering 111 novel early brain-expressed miRNAs, and identified 85 local-miRNA-eQTLs. Colocalization of miRNA-eQTLs with GWAS summary… Show more
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