MicroRNA: Endotyping United Airways?

Martínez-Antón, Asunción; Mullol, Joaquim

doi:10.1159/000362333

Cited by 4 publications

(7 citation statements)

References 46 publications

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“…A number of individual miRNAs have been associated with upper or lower airway diseases [ 36 ], and emerging results [ 19 ] have shown how the expression pattern of circulating miRNAs might have potential for use as non-invasive biomarkers to diagnose and characterize these diseases. However, collaborative study of a particular miRNA in both upper and lower airway diseases simultaneously is lacking.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA in United Airway Diseases

Liu

Zhang

Callejas-Díaz

et al. 2016

IJMS

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The concept of united airway diseases (UAD) has received increasing attention in recent years. Sustained and increased inflammation is a common feature of UAD, which is inevitably accompanied with marked gene modification and tight gene regulation. However, gene regulation in the common inflammatory processes in UAD remains unclear. MicroRNA (miRNA), a novel regulator of gene expression, has been considered to be involved in many inflammatory diseases. Although there are an increasing number of studies of miRNAs in inflammatory upper and lower airway diseases, few miRNAs have been identified that directly link the upper and lower airways. In this article, therefore, we reviewed the relevant studies available in order to improve the understanding of the roles of miRNAs in the interaction and pathogenesis of UAD.

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Section: Discussionmentioning

confidence: 99%

MicroRNA in United Airway Diseases

Liu

Zhang

Callejas-Díaz

et al. 2016

IJMS

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“…The pathogenesis and the gene regulation of the UAD are unclear, and so far only a few studies have investigated the role of miRNAs in these processes 77,78 . Two articles from the same group analyzed the miRNAs expression profiles in the nasal mucosa of patients with coexistence of AR and asthma.…”

Section: Mirnas In United Airway Diseasesmentioning

confidence: 99%

“…In clinical medicine, the observable characteristics or “traits” associated with a disease are termed “phenotype.” The different phenotypes associated with CRS and AR may also have different pathophysiological mechanisms or so‐called “endotypes.” Thus, endotyping of these diseases would help in a better understanding of the mechanisms involved in tuning immune response and inflammation. Finally, it would be essential to develop adequate treatments, from pharmacotherapy to surgery and biologics 45–49 …”

Section: Introductionmentioning

confidence: 99%

“…Finally, it would be essential to develop adequate treatments, from pharmacotherapy to surgery and biologics. [45][46][47][48][49] Recently, the role of miRNAs in CRS and AR has been investigated with growing interest. 50 In this review, we summarize the latest knowledge about the role and function of miRNAs to underline their potential usage as biomarkers for the diagnosis, and as targets for the treatment of CRS and AR.…”

Section: Introductionmentioning

confidence: 99%

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Role of microRNAs in inflammatory upper airway diseases

Tubita

Callejas-Díaz

Roca‐Ferrer

et al. 2020

Allergy

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MicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play a role in regulating immune functions and inflammation and are implicated in controlling the development and activation of T and B cells. Inflammatory chronic upper airway diseases, such as rhinitis and rhinosinusitis, are spread all over the world and characterized by an exaggerated inflammation involving a complex interaction between immune and resident cells. Until now and despite allergy, little is known about their etiology and the processes implicated in the immune response and tuning inflammation of these diseases. This review highlights the knowledge of the current literature about miRNAs in inflammatory chronic upper airways diseases and how this may be exploited in the development of new clinical and therapeutic strategies.

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“…Since a particular miRNA can target hundreds of genes, miRNAs affect the expression of a large proportion of genes and, as a result, regulate multiple cellular processes. Dysregulated expression of miRNAs has been shown in cancer and in inflammatory diseases, including upper and united airway diseases [101][102][103][104]. An overexpression of miR-125b, a regulator of innate immunity, has been reported in eosinophilic CRSwNP [102].…”

Section: Micrornasmentioning

confidence: 99%

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

López-Chacón

Mullol

Pujols

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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MicroRNA: Endotyping United Airways?

Cited by 4 publications

References 46 publications

MicroRNA in United Airway Diseases

MicroRNA in United Airway Diseases

Role of microRNAs in inflammatory upper airway diseases

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

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