2019
DOI: 10.1038/s41556-019-0272-y
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MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

Abstract: Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over time and recovery after changes in mechanical stress. However, the regulatory pathways that mediate these effects are unknown. A comprehensive identification of Argonaute-2(AGO2)-associated microRNAs and mRNAs in endothelial cells identified a network of 122 microRNA families that target 73 mRNAs encoding cytoskeletal, contractile, adhesive and extracellular matrix (CAM) proteins. These microRNAs increased in cells pla… Show more

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Cited by 50 publications
(43 citation statements)
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References 68 publications
(79 reference statements)
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“…The variability of impact on the different levels of cell/cell, cell/tissue, and tissue/tissue interaction ranges from 0.1 to 100 kPa from development to adult life and produces a complex interactive network of physics and biochemistry involving both muscle and bone [3,[6][7][8].…”
Section: Forces Generated By Exercise Locomotion and External Vibramentioning
confidence: 99%
“…The variability of impact on the different levels of cell/cell, cell/tissue, and tissue/tissue interaction ranges from 0.1 to 100 kPa from development to adult life and produces a complex interactive network of physics and biochemistry involving both muscle and bone [3,[6][7][8].…”
Section: Forces Generated By Exercise Locomotion and External Vibramentioning
confidence: 99%
“…A pure culture of sinus node fibroblasts was obtained based on a previously described method by Moro et al 97 .…”
Section: Isolation and Culture Of Sinus Node Fibroblastsmentioning
confidence: 99%
“…Die Freisetzung des Inhalts kann durch Entleerung in die Umgebungsflüssigkeiten ebenso geschehen wie durch Fusion mit einer Zielzelle, wodurch der Inhalt ins Zellinnere entleert wird. Auf diese Weise können Wachstums-und Differenzierungsprogramme von Zellen und Geweben über die Zirkulation auch aus der Entfernung beeinflusst werden [28,37,38].…”
Section: Mechanismen Adaptiver Sekretorischer Kommunikation Zwischen unclassified