MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review

Borgia, Francesco; Peterle, Lucia; Custurone, Paolo; Vaccaro, Mario; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.3390/ijms23063241

Cited by 8 publications

(4 citation statements)

References 49 publications

(55 reference statements)

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“…miRs are involved in several steps of AV etiopathogenesis. miR-21 has pro-inflammatory effects and is also associated with the fibrotic process in patients with AV [12]. In the study by Ghumra et al [1], it was shown that miR-21 levels were increased in both the plasma and tissue of patients with AV and that this miR was an early marker for the development of atrophic scarring.…”

Section: Discussionmentioning

confidence: 96%

“…MicroRNAs (miRs) are small RNA molecules transcribed from RNA genes in protein-coding and non-proteincoding regions of the genome but are not translated into proteins [10,11]. miRs affect keratinocyte maturation and cooperation and participate in the pathogenesis of AV, resulting in different outcomes depending on the deficiency or overexpression of their levels [12].…”

Section: Introductionmentioning

confidence: 99%

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A Study of FoxO1, mTOR, miR-21, miR-29b, and miR-98 Expression Levels Regarding Metabolic Syndrome in Acne Vulgaris Patients

Akdağ,

Atli,

Zhuri̇

et al. 2024

Cureus

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Background: Acne vulgaris (AV) is an inflammatory skin disease caused by the mechanistic target of rapamycin complex 1 (mTORC1). forkhead box protein (Fox) O1 is known to regulate the relationship between the mTORC1 signaling pathway and insulin resistance (IR). Increased mTORC1 signaling is known to predispose one to diseases such as insulin resistance (IR), obesity, and diabetes mellitus. One of the major components of mTORC1 is mTOR. FoxO1 and mTOR play key roles in the onset and progression of metabolic syndrome (MetS). In this study, we aimed to elucidate the relationship between AV and MetS through FoxO1 and mTOR signaling pathways and microRNAs (miRs) associated with these signaling pathways.Methods: We examined 20 AV patients without MetS, 16 AV patients with MetS, and 20 healthy controls. The demographic characteristics of the patients, MetS parameters, clinical severity of AV (Global Acne Grading System, GAGS), and the homeostasis model assessment (HOMA) values were compared between the groups. In addition, the expression levels of FoxO1 and mTOR genes, along with the expression levels of miR-21, miR-29b, and miR-98, were assessed in skin biopsy samples from all groups using real-time polymerase chain reaction methods. FoxO1, mTOR, and miRNA expression levels were recorded as fold change.Results: The mean age of patients with AV without MetS was statistically lower. In AV patients with MetS, those with moderate GAGS scores had statistically significantly higher HOMA values than those with mild GAGS scores. FoxO1 expression was significantly lower in AV patients compared to controls. The mTOR expression levels of AV patients with MetS were significantly higher than the other two groups. The expression levels of miR-21 and miR-29b were significantly increased in the group of AV patients with MetS compared to the group of AV patients without MetS.Conclusions: These results suggested that the mTOR pathway may play an important role in explaining the relationship between AV and MetS in acne pathogenesis. They also suggested that miR-21 and miR-29b play a role in the inflammatory process of AV.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

A Study of FoxO1, mTOR, miR-21, miR-29b, and miR-98 Expression Levels Regarding Metabolic Syndrome in Acne Vulgaris Patients

Akdağ,

Atli,

Zhuri̇

et al. 2024

Cureus

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“…As mentioned-above, various circulating miRNAs exhibit dysregulation in both HS-affected tissues and blood ( Wang et al, 2016 ). These miRNAs are recognized for their interactions with genes embedded within inflammatory pathways, encompassing Toll-like receptor signaling, cytokine production, and immune cell recruitment ( Borgia et al, 2022 ). As a consequence, it can be hypothesized that their dysregulation perpetuates HS-related inflammation and serves as indicative biomarkers for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

Moltrasio,

Silva,

Tricarico

et al. 2024

Front. Genet.

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MicroRNAs (miRNAs) play a crucial role in the early diagnosis of autoinflammatory diseases, with Hidradenitis Suppurativa (HS) being a notable example. HS, an autoinflammatory skin disease affecting the pilosebaceous unit, profoundly impacts patients’ quality of life. Its hidden nature, with insidious initial symptoms and patient reluctance to seek medical consultation, often leads to a diagnostic delay of up to 7 years. Recognizing the urgency for early diagnostic tools, recent research identified significant differences in circulating miRNA expression, including miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p, between HS patients and healthy controls. These miRNAs serve as potential biomarkers for earlier disease detection. Traditional molecular biology techniques, like reverse transcription quantitative-polymerase chain reaction (RT-qPCR), are employed for their detection using specific primers and probes. Alternatively, short peptides offer a versatile and effective means for capturing miRNAs, providing specificity, ease of synthesis, stability, and multiplexing potential. In this context, we present a computational simulation pipeline designed for crafting peptide sequences that can capture circulating miRNAs in the blood of patients with autoinflammatory skin diseases, including HS. This innovative approach aims to expedite early diagnosis and enhance therapeutic follow-up, addressing the critical need for timely intervention in HS and similar conditions.

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“…Multiple miRNA (miR-155, miR-223, miR-21, and miRNA-146a) levels were found to be altered in acne vulgaris. These miRNAs are related to pathogenetic aspects, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

et al. 2023

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Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10 , etc. Further analysis revealed that differentially methylated genes ( PARP8 and MAPKAPK2 ) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne.

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MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review

Cited by 8 publications

References 49 publications

A Study of FoxO1, mTOR, miR-21, miR-29b, and miR-98 Expression Levels Regarding Metabolic Syndrome in Acne Vulgaris Patients

A Study of FoxO1, mTOR, miR-21, miR-29b, and miR-98 Expression Levels Regarding Metabolic Syndrome in Acne Vulgaris Patients

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

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