MicroRNA Biogenesis Pathway Gene Polymorphisms Are Associated with Breast Cancer Risk

Argonaute Proteins Take Center Stage in Cancers

“…Moreover, another of the analyzed AGO1 SNPs variant, rs595961 AG, was implicated as a cancer risk factor for the Asian population [122]. [111] rs636832 A/A Breast cancer Increased [112] rs636832 AA + A Gastric cancer Decreased [113] rs636832 A > G Lung cancer Decreased [115] rs595961 AG Lung cancer Increased [114] rs595961 AG + GG Clear cell renal cell carcinoma Decreased [116] AGO2 rs3928672 GA + AA Nasopharyngeal carcinoma Increased [109] rs11786030 A/G Breast cancer Increased [110] rs2292779 C/G Breast cancer Increased [110] rs2977490 G/G Breast cancer Increased [112]…”

“…Based on the analysis of 488 breast cancer specimens, Sung and colleagues depicted that two AGO2 genetic variants, rs11786030 A/G and rs2292779 C/G, were correlated with elevated risk of breast cancer [ 110 ]. In like manner, the polymorphism of the AGOs encoding genes in breast cancer cases was analyzed for 417 Russian patients [ 111 ]. The study did not signal a significant impact of AGO2 SNPs; however, rs595055 C/T, one of the AGO1 genetic variants, was associated with augmented breast cancer risk [ 111 ].…”

“…In like manner, the polymorphism of the AGOs encoding genes in breast cancer cases was analyzed for 417 Russian patients [ 111 ]. The study did not signal a significant impact of AGO2 SNPs; however, rs595055 C/T, one of the AGO1 genetic variants, was associated with augmented breast cancer risk [ 111 ]. Further studies on the influence of AGO1 and AGO2 SNPs on breast cancer susceptibility were conducted on 93 Mediterranean cases and uncovered another AGO1 SNP (rs636832 A/A), as well as one more AGO2 (rs2977490 G/G) variant associated with elevated risk of the disease [ 112 ].…”

Micro-RNA Biogenesis Genes (AGO1 and GEMIN4) Single Nucleotide Variants of Bad Prognosis and Poor Therapeutic Response in Egyptian Chronic Myeloid Leukemia Patients: Case–control Study

“…It is an important component of miRISC that plays a pivotal role in carcinogenesis. GEMIN4 expression is related to the biogenesis of its linked miRs that affect cancer risk and prognosis [13]. GEMIN4 interacts through MR receptor [25].…”

“…GEMIN 4 gene is subsisted on chromosome 17p13.3, encoding the Gemin4 protein which is essential component of the miRISC complex [12]. The rs2740348 single genetic variants (SNV) of GEMIN4 are found to be related to rise breast cancer risk and with reduced risk for prostate cancer development [9], [13].…”