microRNA Biogenesis during Cellular Senesence Induced by Chronic Stress of the Endoplasmic Reticulum
A. A. Kubatiev,
A. A. Moskovtsev,
D. M. Zaichenko
et al.
Abstract:MicroRNAs are small non-coding regulatory RNAs about 22 nt long, post-transcriptional and transcriptional regulators of gene expression that stabilize the cellular phenotype and play an important role in differentiation, development, and apoptosis. MicroRNA biogenesis includes several precisely controlled post-transcriptional stages of processing and transport, including cytoplasmic cleavage of pre-miRNA by type III ribonuclease DICER with the formation of a mature duplex included in the RISC complex. The role… Show more
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