MicroRNA-based therapy for glioblastoma: Opportunities and challenges

Lei, Qingchun; Yang, Yong-Min; Zhou, Wenhui; Liu, Wenwen; Li, Yixin; Qi, Nanchang; Li, Qiangfeng; Wen, Zhang; Ding, Lei; Huang, Xiaobin; Liu, Yu; Wu, Jin

doi:10.1016/j.ejphar.2022.175388

Cited by 13 publications

(7 citation statements)

References 179 publications

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“…On the contrary, 277.5 μM OLE increased Let-7d levels only. Expression of miR-153 was not changed by OLE treatments [ 95 , 224 , 225 , 226 ].…”

Section: Effects Of Ole and Ht On Solid Tumorsmentioning

confidence: 99%

Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

Gervasi,

Pojero

2024

Biomedicines

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The fact that the Mediterranean diet could represent a source of natural compounds with cancer-preventive and therapeutic activity has been the object of great interest, especially with regard to the mechanisms of action of polyphenols found in olive oil and olive leaves. Secoiridoid oleuropein (OLE) and its derivative hydroxytyrosol (3,4-dihydroxyphenylethanol, HT) have demonstrated anti-proliferative properties against a variety of tumors and hematological malignancies both in vivo and in vitro, with measurable effects on cellular redox status, metabolism, and transcriptional activity. With this review, we aim to summarize the most up-to-date information on the potential use of OLE and HT for cancer treatment, making important considerations about OLE and HT bioavailability, OLE- and HT-mediated effects on drug metabolism, and OLE and HT dual activity as both pro- and antioxidants, likely hampering their use in clinical routine. Also, we focus on the details available on the effects of nutritionally relevant concentrations of OLE and HT on cell viability, redox homeostasis, and inflammation in order to evaluate if both compounds could be considered cancer-preventive agents or new potential chemotherapy drugs whenever their only source is represented by diet.

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“…On the contrary, 277.5 μM OLE increased Let-7d levels only. Expression of miR-153 was not changed by OLE treatments [ 95 , 224 , 225 , 226 ].…”

Section: Effects Of Ole and Ht On Solid Tumorsmentioning

confidence: 99%

Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

Gervasi,

Pojero

2024

Biomedicines

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“…Functional miRNA liposomes have been developed in TNBC cells to inhibit the TGF-β1/SMAD pathway and SLUG expression, thereby enhancing the efficacy of chemotherapy in mice. In order to treat BC, epigenetic methods such as functionally cooperative miRNAs or histone deacetylase inhibitors are useful for blocking HER3 signal transduction ( 95 ). Moreover, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) therapy results in the elevation of circulating miRNA through miR-3942-3p/BARD1, which inhibits the cell cycle and promotes apoptosis to end BC ( 96 ).…”

Section: Mirna As New Diagnostic and Prognostic Markersmentioning

confidence: 99%

The role of miRNAs as biomarkers in breast cancer

Baylie,

Kasaw,

Getinet

et al. 2024

Front. Oncol.

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Breast cancer (BC) is the second most common cause of deaths reported in women worldwide, and therefore there is a need to identify BC patients at an early stage as timely diagnosis would help in effective management and appropriate monitoring of patients. This will allow for proper patient monitoring and effective care. However, the absence of a particular biomarker for BC early diagnosis and surveillance makes it difficult to accomplish these objectives. miRNAs have been identified as master regulators of the molecular pathways that are emphasized in various tumors and that lead to the advancement of malignancies. Small, non-coding RNA molecules known as miRNAs target particular mRNAs to control the expression of genes. miRNAs dysregulation has been linked to the start and development of a number of human malignancies, including BC, since there is compelling evidence that miRNAs can function as tumor suppressor genes or oncogenes. The current level of knowledge on the role of miRNAs in BC diagnosis, prognosis, and treatment is presented in this review. miRNAs can regulate the tumorigenesis of BC through targeting PI3K pathway and can be used as prognostic or diagnostic biomarkers for BC therapy. Some miRNAs, like miR-9, miR-10b, and miR-17-5p, are becoming known as biomarkers of BC for diagnosis, prognosis, and therapeutic outcome prediction. Other miRNAs, like miR-30c, miR-187, and miR-339-5p, play significant roles in the regulation of hallmark functions of BC, including invasion, metastasis, proliferation, resting death, apoptosis, and genomic instability. Other miRNAs, such as miR-155 and miR-210, are circulating in bodily fluids and are therefore of interest as novel, conveniently accessible, reasonably priced, non-invasive methods for the customized care of patients with BC.

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“…This is crucial for achieving therapeutic concentrations of miRNAs in the tumor microenvironment. As a result, nanoparticle-based delivery approaches hold great potential for improving the overall efficacy of miRNA-based therapies in neuro-oncology [ 129 ].…”

Section: Mirnas and Their Contribution In Neuro-oncologymentioning

confidence: 99%

Methods of miRNA delivery and possibilities of their application in neuro-oncology

Gareev,

Beylerli,

Tamrazov

et al. 2023

Non-coding RNA Research

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MicroRNA-based therapy for glioblastoma: Opportunities and challenges

Cited by 13 publications

References 179 publications

Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

The role of miRNAs as biomarkers in breast cancer

Methods of miRNA delivery and possibilities of their application in neuro-oncology

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