MicroRNA-based system in stem cell reprogramming; differentiation/dedifferentiation

Pourrajab, Fatemeh; Zarch, Mojtaba Babaei; BaghiYazdi, Mohammad; Hekmatimoghaddam, Seyedhossein; Zare-Khormizi, Mohammad Reza

doi:10.1016/j.biocel.2014.08.008

Cited by 17 publications

(20 citation statements)

References 83 publications

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“…13,14 MiRNAs are important regulators in various fundamental biological and pathological processes, such as cell proliferation, apoptosis, differentiation, metabolism, and cancer, as well as autophagy. [15][16][17][18][19][20] MiRNAs have recently been identified as important regulators of autophagy. 19 Some miRNAs suppress autophagic activity via targeting autophagy-related proteins (ATGs) under stress conditions.…”

Section: Introductionmentioning

confidence: 99%

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

Huang

Qiu

et al. 2015

Cancer Biology & Therapy

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Abbreviations: BAFA1, bafilomycin A1; CPT, Camptothecin; miRNA, microRNA; LC3, microtubule-associated protein 1 light chain 3; mTOR, mechanistic target of rapamycin; Rictor, Rptor independent companion of mTOR complex 2; MUT, mutated; UTR, untranslated region; NC, negative control.It has been reported that persistent or excessive autophagy promotes cancer cell death during chemotherapy, either by enhancing the induction of apoptosis or mediating autophagic cell death. Here, we show that miR-15a and miR-16 are potent inducers of autophagy. Rictor, a component of mTORC2 complex, is directly targeted by miR-15a/16. Overexpression of miR-15a/16 or depletion of endogenous Rictor attenuates the phosphorylation of mTORC1 and p70S6K, inhibits cell proliferation and G1/S cell cycle transition in human cervical carcinoma HeLa cells. Moreover, miR15a/16 dramatically enhances anticancer drug camptothecin (CPT)-induced autophagy and apoptotic cell death in HeLa cells. Collectively, these data demonstrate that miR-15a/16 induced autophagy contribute partly to their inhibition of cell proliferation and enhanced chemotherapeutic efficacy of CPT.

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Section: Introductionmentioning

confidence: 99%

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

Huang

Qiu

et al. 2015

Cancer Biology & Therapy

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“…The cell cycle progression is tightly regulated, by modulating the activity of Cdc25a, CCN-E and CCN-D. CCN-D activates Cdk4/6 in early G1 for progression in this phase. CCN-E is needed to activate Cdk2 at the late stage of G1, in particular, for G1/S transition and passage into the S phase of cell cycle [41,46]. Thereafter, CCN-A/Cdk2 complex assures S phase progression, and CCN-B/Cdk1 integration completes mitosis.…”

Section: Cell Cycle Withdrawal By Ischaemia-induced Mir-15 Sequence-smentioning

confidence: 99%

MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis

Pourrajab

Zarch

Hekmatimoghaddam

et al. 2015

J Cellular Molecular Medi

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The age‐related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double‐edged sword in the development and prognosis of ischaemia‐associated diseases. Evidence evokes microRNAs (miRNAs) as molecular switchers that underlie cellular events in different tissues. Here, miRNAs would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of miRNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell‐based therapy.

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“…The IGF-1/IRS1/PI3K/Akt pathway downstream effector FOXO is the most relevant one attributable to longevity in mammalians and in human Pourrajab et al, 2014aPourrajab et al, , 2014b. A growing number of evidence link FOXO to longevity and to chromatin-remodeling system PARP1/SIRT1 which also controls trophic and bioenergetic pathways (Rodier and Campisi, 2011;Gorospe and Abdelmohsen, 2011;Zhao et al, 2010).…”

Section: A Brief Introduction To the Signaling Pathways Involved In Cmentioning

confidence: 97%

“…The Akt pathway positively regulates cell cycle progression and proliferation by reducing the expression levels of critical cell cycle inhibitors p53/p21/p16 Gorospe and Abdelmohsen, 2011;Pourrajab et al, 2014aPourrajab et al, , 2014b.…”

Section: A Brief Introduction To the Signaling Pathways Involved In Cmentioning

confidence: 98%

“…Interestingly, down-regulated SA-miR-17-92 emerges as one of the major difference between adult CSCs and their primary progenitor populations Noren Hooten et al, 2010;Pourrajab et al, 2014aPourrajab et al, , 2014b, which is commonly associated with stem cell re-growth and proliferation . Therefore, miR-17-92 cluster appears as a reprogramming switcher whose up-regulation is clearly associated with cell renovation/proliferation or reversely its downregulation brings heart to senescence (van Almen et al, 2011;Bagnall et al, 2012).…”

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confidence: 99%

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The master switchers in the aging of cardiovascular system, reverse senescence by microRNA signatures; as highly conserved molecules

Pourrajab

Zarch

Hekmatimoghaddam

et al. 2015

Progress in Biophysics and Molecular Biology

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MicroRNA-based system in stem cell reprogramming; differentiation/dedifferentiation

Cited by 17 publications

References 83 publications

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis

The master switchers in the aging of cardiovascular system, reverse senescence by microRNA signatures; as highly conserved molecules

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